Ventricular Remodeling and Heart Failure After Myocardial Infarction: A Community Study

April 8, 2024 updated by: Suzette J. Bielinski, Mayo Clinic
To comprehensively characterize Left Ventricular (LV) remodeling after Myocardial Infarction (MI) in the community, study the association between patterns of remodeling and biological pathways and examine the association between the predictors of remodeling and heart failure after Myocardial Infarction.

Study Overview

Status

Active, not recruiting

Conditions

Study Type

Observational

Enrollment (Actual)

1599

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • United States
    • Minnesota
      • Rochester, Minnesota, United States, 55905
        • Mayo Clinic

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

No

Sampling Method

Non-Probability Sample

Study Population

Subjects in the 7 County area who are admitted to the Mayo Clinic Hospitals in Rochester, Minnesota who have their first myocardial infarction and are willing to have blood drawn and return for an echocardiogram in 3 months.

Description

Inclusion Criteria:

  1. Hospitalized patients with a clinical diagnosis of Myocardial Infarction.
  2. Residents of Olmsted, Dodge, Goodhue, Wabasha, Winona, Fillmore and Mower Counties.
  3. Able to provide informed consent.

Exclusion Criteria:

  1. Previous clinical diagnosis of Myocardial Infarction
  2. Previous diagnosis of Heart Failure and/or Cardiomyopathy
  3. Diagnosis of Apical Ballooning Syndrome
  4. Planned Coronary Artery Bypass Graft (CABG) during index hospitalization
  5. Unable to provide informed consent

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Myocardial Infarction subjects
Subjects with first Myocardial Infarction presenting to one of the Mayo Clinic Hospitals in Rochester, Minnesota.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Heart Failure
Time Frame: 5 years
Development of Heart Failure post Myocardial Infarction
5 years

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Death
Time Frame: 5 years
All cause mortality post Myocardial Infarction
5 years

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Mayo Clinic

Collaborators

National Heart, Lung, and Blood Institute (NHLBI)

Investigators

  • Principal Investigator: Suzette Bielinski, PhD, Mayo Clinic

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

Helpful Links

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

January 1, 2014

Primary Completion (Actual)

August 31, 2018

Study Completion (Estimated)

January 1, 2025

Study Registration Dates

First Submitted

January 23, 2014

First Submitted That Met QC Criteria

January 24, 2014

First Posted (Estimated)

January 28, 2014

Study Record Updates

Last Update Posted (Actual)

April 9, 2024

Last Update Submitted That Met QC Criteria

April 8, 2024

Last Verified

April 1, 2024

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 13-009187
  • R01HL136659 (U.S. NIH Grant/Contract)

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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