The Focal Electro-Oculogram in Macular Disease

Background:

- Maculopathies are eye conditions that affect the center of the retina. Retina health depends on the retinal pigment epithelium (RPE), a layer behind the retina. A new test may measure the health of the central retina and RPE.

Objective:

- To use the focal electro-oculogram (EOG) test to understand how the central retina and RPE are affected in maculopathies.

Eligibility:

• People at least 10 years old with a maculopathy.
• Healthy volunteers with visual acuity of 20/20 or better in at least one eye.

Design:

• Participants will be screened with medical and eye history and an eye exam. Pictures will be taken of the eyes.
• Their eyes may be dilated.
• They may have a field test. They will look into a lens and press a button when they see a light. First, they may sit in the dark for 40 minutes.
• Participants will have 1-7 visits over 18 months.
• Their vision will be tested and eye pressure measured.
• Their pupils will be dilated with eye drops and researchers may take pictures of the retina and the inside of the eye, and measure the thickness of the retina.
• Participants will have an electro-oculogram. They will look at a 2 LED lights and follow them back and forth for 10 seconds once per minute. Participants will be in darkness for 15 minutes and in light for 20 minutes. One skin electrode will be placed on the nose and one next to the eye.
• Participants with maculopathy will also have:
• Field test.
• Electroretinogram. Participants will get numbing eye drops and special contact lenses. A small metal electrode will be taped to the forehead. Participants will watch flashing lights and try not to blink. First, they may sit in the dark for 40 minutes.

Study Overview

• Status: Completed
• Conditions: Age-Related Macular Degeneration; Macular Degeneration

Detailed Description

OBJECTIVE:

The objective of this protocol is to investigate the local response of the retinal pigment epithelium (RPE) across the posterior pole of the eye by recording the focal electrooculogram (EOG) in participants with macular disease.

STUDY POPULATION:

Up to 50 healthy volunteers and 80 participants, age 10 or older, with macular disorders affecting the retina/retinal pigment epithelium complex. Examples of such macular disorders include Stargardt s disease and age-related macular degeneration (AMD).

DESIGN:

This single-center, observational, case-control study will be comprised of three related aims. The first aim is focused on developing the focal EOG method which will require parameter optimization. The second aim is focused on establishing the normal range and variability of the focal EOG in normal volunteers. The third aim is to examine the focal EOG in participants with macular disease.

OUTCOME MEASURES:

The primary outcome for this study is to develop a method for recording the focal EOG. The secondary outcome will be to establish the normal range for the focal EOG and determine the inter-session and intra-session variabilities of this test. Exploratory outcomes include: 1) to examine the focal EOG in participants with macular diseases and 2) determine the inter-session and intra-session variabilities of this test in participants with macular diseases.

• Study Type: Observational
• Enrollment (Actual): 39

Contacts and Locations

Study Locations

• United States
  • Maryland
    • Bethesda, Maryland, United States, 20892
      • National Institutes of Health Clinical Center

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 10 years and older (Child, Adult, Older Adult)
• Accepts Healthy Volunteers: No

• Sampling Method: Non-Probability Sample

Study Population

Up to 50 healthy volunteers and 80 participants, age 10 or older, with macular disease; examples of such disorders include Stargardt s disease and age-related macular degeneration (AMD). NIH employees meeting the eligibility criteria may participate in this study.

Description

• INCLUSION CRITERIA:

  1. Participant must be 10 years of age or older.
  2. Participant (or legal guardian) must understand and sign the protocol s informed consent document.
  3. Participant must be able to cooperate with the testing required for this study.

  4. For Participants with macular disease only:

     1. Participant must have macular disease, defined as evidence of loss of centrally mediated retinal dysfunction and/or degeneration as established by standard clinical methods including perimetry, ERG and imaging.
     2. Participant must have a measurable visual acuity.

  5. For Healthy Volunteers only:

     1. Participant must have visual acuity of 20/20 or better in at least one eye.

EXCLUSION CRITERIA:

1) Participant with pre-retinal media opacities that would prevent focal light presentation.

Study Plan

How is the study designed?

Design Details

• Observational Models: Case-Control
• Time Perspectives: Prospective

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort
Unaffected; Healthy volunteers
Affected; Participants with macular disease

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
develop method for recording focal EOG	to develop a method for recording the focal EOG in response to a central light stimulus	up to 6 months

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
establish the normal range for the focal EOG and determine the inter-session and intra-session variabilities of this test	establish the normal range for the focal EOG and determine the inter-session and intra-session variabilities of this test	up to 18 months

Collaborators and Investigators

• Sponsor: National Eye Institute (NEI)
• Investigators: Principal Investigator: Brett G Jeffrey, Ph.D., National Eye Institute (NEI)

Publications and helpful links

Helpful Links

• NIH Clinical Center Detailed Web Page

Study record dates

Study Major Dates

• Study Start (Actual): February 6, 2015
• Primary Completion (Actual): May 7, 2019
• Study Completion (Actual): February 28, 2020

Study Registration Dates

• First Submitted: August 23, 2014
• First Submitted That Met QC Criteria: August 23, 2014
• First Posted (Estimated): August 26, 2014

Study Record Updates

• Last Update Posted (Actual): April 25, 2024
• Last Update Submitted That Met QC Criteria: April 24, 2024
• Last Verified: January 30, 2024

More Information

Terms related to this study

• Keywords: Natural History; Retinal Pigment Epithelium; Retinal Images
• Additional Relevant MeSH Terms: Eye Diseases; Retinal Degeneration; Retinal Diseases; Macular Degeneration
• Other Study ID Numbers: 140171; 14-EI-0171

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No