Improving Muscle Assessment in Older Adults - The "Can We Build a Better Mouse Trap?" Study

The primary aim of this study is to compare traditional muscle function tests with computerized versions using body-worn motion sensors and video motion analysis of the same tests. The investigators selected the Timed Up and Go (TUG) test as the investigators primary variable for this aim with several other function tests (e.g., repeated chair rise, 6-meter walk, 2-minute walk, Romberg stance, semi-tandem / tandem stance) as secondary variables. The investigators primary hypothesis is that the computerized versions of the TUG test are highly correlated (>0.9) with the traditional method, but with comparable or better reproducibility. Secondary analyses will correlate other function tests with their computerized version, again with the hypothesis that they are highly correlated and that computerized versions are of similar or better reproducibility. This analysis will also compare traditional assessments of balance with a computerized balance method, computerized dynamic posturography.

Study Overview

• Status: Completed
• Conditions: Sarcopenia
• Intervention / Treatment: Other: No intervention

• Study Type: Observational
• Enrollment (Actual): 112

Contacts and Locations

Study Locations

• United States
  • Wisconsin
    • Madison, Wisconsin, United States, 53705
      • University of Wisconsin-Madison Osteoporosis Clinical Research Program

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 70 years and older (Older Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

This study will evaluate community dwelling women and men ≥ 70 years recruited from the Madison, Wisconsin area.

Description

Inclusion Criteria:

1. Ambulatory, community dwelling men and women age ≥ 70 years
2. Able and willing to sign informed consent
3. Able to stand without assistance

Exclusion Criteria:

1. History of myocardial infarction within the prior six months or ongoing angina
2. History of injury or surgery within the prior six months which limits the ability to ambulate
3. History of malignancy with metastasis to the musculoskeletal system
4. Neuromuscular disease or severe end organ disease impairing balance or muscle function to the degree that completion of all study tests is unlikely.

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
The comparison of results of traditional physical function tests with the results of computerized versions (body worn sensors and Kinect system) of the same tests.	Short-term reproducibility of traditional vs. computerized functional tests will also be compared.	All physical function tests will be performed at the first visit and visit 2 up to 4 days later

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Explore the capabilities of the Microsoft Kinect system to record and analyze muscle function tests and correlate the Microsoft Kinect system to a gold standard motion analysis system.		All physical function tests will be performed at the first visit and visit 2 up to 4 days later.
Validate the use of BIS (Bioelectrical Impedance Spectroscopy) to adjust DXA (Dual Energy X-ray Absorptiometry) -measured body composition by providing muscle mass measurement	The relationship of lean mass, as estimated by DXA and BIS with muscle mass as measured by deuterated creatine dilution as a nominal gold standard. Additionally, the correlation of lean mass as measured by DXA and muscle mass as measured by BIS and creatine dilution with muscle function tests.	BIS is performed at visit 1 and visit 2 up to 4 days later. DXA is performed at visit 2.
Correlate various ratios of lean or muscle mass / DXA measured fat mass with functional tests.		All physical function tests will be performed at the screen and follow up visits.

Collaborators and Investigators

• Sponsor: University of Wisconsin, Madison

Study record dates

Study Major Dates

• Study Start: February 1, 2015
• Primary Completion (Actual): October 1, 2015
• Study Completion (Actual): October 1, 2015

Study Registration Dates

• First Submitted: October 3, 2014
• First Submitted That Met QC Criteria: November 14, 2014
• First Posted (Estimate): November 20, 2014

Study Record Updates

• Last Update Posted (Estimate): March 28, 2016
• Last Update Submitted That Met QC Criteria: March 25, 2016
• Last Verified: March 1, 2016

More Information

Terms related to this study

• Keywords: Sarcopenia, muscles, aging
• Additional Relevant MeSH Terms: Nervous System Diseases; Neurologic Manifestations; Neuromuscular Manifestations; Pathological Conditions, Anatomical; Muscular Atrophy; Atrophy; Sarcopenia
• Other Study ID Numbers: 2014-1109