Health Behaviors and Time-of-Day: Older Adult Cognitive Function (OA-TIME)

Modifiable Health Behaviors Associated With Time-of-Day Differences in Older Adults' Practice-Related Learning

This is a single-center, observational study design. Enrolled participants will be typically, healthy older adults. Participants will complete daily computerized measures, in addition to continuously wearing an Actiwatch device. The study period will last 2 weeks. The objectives of the study are to examine the impact of sleep, pain, and circadian rhythm on practice-related learning in older adults at their preferred versus nonpreferred times of day.

Study Overview

• Status: Completed
• Conditions: Ageing; Alteration of Cognitive Function
• Intervention / Treatment: Device: Polysomnograph; Device: Actiwatch

Detailed Description

Participants will be asked to review the informed consent and consent to the study prior to any study procedure.

There are four stages to this study: 1. a telephone interview, 2. an in-person interview and completion of questionnaires, 3. an in-home single night sleep recording, and 4. two weeks of computerized cognitive testing, subjective sleep and pain recordings, and wearing a Actiwatch.

During the telephone interview, participants will be asked question about their age, sleep, pain, and medical/mental health history. At a second visit, participants will complete a more in-depth interview of their physical health, mental health, sleep, and pain history. They will complete a brief test of their cognitive functioning. They will also complete 4 questionnaires about their time of day preference and mood. At the third visit, participants will visit the University of Florida to be connected to a machine which will monitor their sleep. Participants will return home to sleep while still connected to the machine and will return the machine to the University of Florida the next day. Participants will complete brief computerized daily questionnaires of sleep and pain and cognitive testing in the morning and evening, and and wear an actigraph (wristwatch-like device) that measures arm movements and ambient light for two weeks.

• Study Type: Observational
• Enrollment (Actual): 88

Contacts and Locations

Study Locations

• United States
  • Florida
    • Gainesville, Florida, United States, 32610
      • University of Florida

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 61 years and older (Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Probability Sample

Study Population

Typically, healthy older adults

Description

Inclusion Criteria:

• Age of 65 years and older
• Able to read and speak English
• Completion of Morningness-Eveningness Questionnaire

Exclusion Criteria:

• Significant medical or neurological disorder
• Major psychopathology
• Pain disorder other than fibromyalgia or osteoarthritis
• Sleep disorder other than insomnia
• Cognitive impairment
• Psychotropic or other medications known to alter sleep
• Unable to provide informed consent

Study Plan

How is the study designed?

Design Details

• Observational Models: Cohort
• Time Perspectives: Prospective

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort

Intervention / Treatment

Typically healthy older adults; Adults 65 years and older with only common late-life medical conditions who will complete a screening that includes a Polysomnograph and assessment that includes Actiwatch.

Device: Polysomnograph; Participants will be screened for sleep disorders other than chronic insomnia with an in-home overnight sleep monitoring. Monitoring will consist of six electroencephalography (EEG) measures, two electrooculography (EOG), and chin electromyography (EMG) according to standard placements. Other channels will include oxygen saturation level, bilateral anterior tibialis EMG, heart rate (EKG), thoracic strain gauge, and a nasal/oral thermistor. A single night of polysomnography will be collected during the 2 weeks of assessment.; Other Names: AURA Recording System, Grass Technologies; Device: Actiwatch; This device will be worn on the wrist for 14 continuous days to measure limb movements and ambient light.; Other Names: Actiwatch-L, Mini Mitter

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Cognition as assessed by computerized neuropsychological testing	Cognitive domains include processing speed, immediate memory, delayed memory, and executive function	Morning and evening completion for 14 days

Collaborators and Investigators

• Sponsor: University of Florida
• Investigators: Principal Investigator: Michael E Robinson, Ph.D., University of Florida

Study record dates

Study Major Dates

• Study Start: March 1, 2015
• Primary Completion (Actual): December 1, 2016
• Study Completion (Actual): December 1, 2016

Study Registration Dates

• First Submitted: November 20, 2014
• First Submitted That Met QC Criteria: November 20, 2014
• First Posted (Estimate): November 24, 2014

Study Record Updates

• Last Update Posted (Actual): December 13, 2019
• Last Update Submitted That Met QC Criteria: December 12, 2019
• Last Verified: December 1, 2019

More Information

Terms related to this study

• Keywords: Pain; Sleep; Older Adults; Circadian Rhythm; Practice-related learning
• Other Study ID Numbers: IRB201400910

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: No