Cognitive/Physical Computer-Game Blended Training of Elderly: Neuroscientific LLM Studies (LLM-AUTH)
December 10, 2014 updated by: Panos Bamidis, Aristotle University Of Thessaloniki
Effects of Cognitive and/or Physical Exercises Blended by Computer Games in Elderly: The LLM Project Neuroscientific Investigations in Thessaloniki, Greece by the LLM Team at the Aristotle University of Thessaloniki
The study involved Information and Communication Technologies (ICT) and more specifically computer exercises blended with game activities.
It was hypothesized that ICT facilitated, game blended cognitive and/or physical exercise improves global cognition when compared to control groups; moreover, these improvements may be manifested by brain activity changes; we explored the impact of potential moderators on combined exercise-induced cognitive benefits, as well as, individual/separate training schemes.
Study Overview
Status
Completed
Intervention / Treatment
Detailed Description
The study was conducted in the Thessaloniki (Greece), in various centers. It was part of the Long Lasting Memories (LLM) project (www.longlastingmemories.eu), which was funded by the European Commission (Information and Communication Technologies Policy Support Program (ICT-PSP) for a three year period (2009-2012). It used a pre-post-test design with the between-participant factor group [intervention(s) vs. passive and/or active control]. Post-test was conducted within 2 weeks after completion of the exercise period. Interventions were carried out in Thessaloniki (Greece) within day care centers, hospitals, senior care centers, a memory outpatient center, local parishes, and at participants' homes.
Centers had to provide 8 exercise weeks, with a frequency of at least 2 physical and 3 cognitive exercise sessions per week, resulting in at least 16 physical and 24 cognitive exercise sessions in total.
A similar trial was registered with Clinical Trial Registration: ClinicalTrials.gov Identifier: NCT02267499
Study Type
Interventional
Enrollment (Actual)
581
Phase
- Not Applicable
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
55 years and older (Adult, Older Adult)
Accepts Healthy Volunteers
Yes
Genders Eligible for Study
All
Description
Inclusion Criteria:
- no severe cognitive impairment [MMSE ≥ 18]
- fluent language skills
- agreement of a medical doctor
- time commitment to the test and exercise protocol.
Exclusion Criteria:
- concurrent participation in another study
- severe physical or psychological disorders which precluded participation in the intervention (i.e., inability to follow instructions)
- unrecovered neurological disorders such as stroke, traumatic brain injury, unstable medication within the past three months
- severe and uncorrectable vision problems, or hearing aid for less than three months.
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Prevention
- Allocation: Non-Randomized
- Interventional Model: Parallel Assignment
- Masking: Single
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
|---|---|
|
Experimental: LLM
LLM training Participants use the FitForAll exergaming computer platform as the physical training component (PTC); Participants use the language adapted Version of the BrainFitness Program as the cognitive training component (CTC)
|
LLM training Participants use the FitForAll exergaming computer platform as the physical training component (PTC); Participants use the language adapted Version of the BrainFitness Program as the cognitive training component (CTC)
Other Names:
|
|
Experimental: PTC
Physical training only.
Participants use the FitForAll exergaming computer platform as the physical training component (PTC).
|
PTC training Participants use the FitForAll exergaming computer platform as the physical training component (PTC)
|
|
Experimental: CTC
Cognitive training only.
Participants use the language adapted Version of the BrainFitness Program as the cognitive training component (CTC)
|
CTC training Participants use the language adapted Version of the BrainFitness Program as the cognitive training component (CTC)
|
|
No Intervention: Passive
Passive Control Participants do not receive an intervention serving as passive controls
|
|
|
Active Comparator: Active
Active Control Participants receive an alternative cognitive training scheme; software was built on purpose by the AUTH team.
The software is called VideoGrade and uses YouTube documentaries.
|
Active cognitive training by use of the VideoGrade software by AUTH.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
|---|---|---|
|
overall cognition
Time Frame: 2 Monhths
|
Greek versions of the California Verbal Learning Test [CVLT], the Digit Span Test and the Trail Making Test [TMT] were used to assess cognitive outcomes
|
2 Monhths
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
|---|---|---|
|
physical fitness
Time Frame: 2 months / 6+2 months / 12+2 months
|
Physical capacity was measured by means of the Senior Fitness Test
|
2 months / 6+2 months / 12+2 months
|
|
Episodic memory
Time Frame: 2 months / 6+2 months / 12+2 months
|
calculated by averaging z-standardized sub-scores of the three cognitive tests (primary outcome)
|
2 months / 6+2 months / 12+2 months
|
|
working memory
Time Frame: 2 months / 6+2 months / 12+2 months
|
calculated by averaging z-standardized sub-scores of the three cognitive tests (primary outcome)
|
2 months / 6+2 months / 12+2 months
|
|
executive function
Time Frame: 2 months / 6+2 months / 12+2 months
|
calculated by averaging z-standardized sub-scores of the three cognitive tests (primary outcome)
|
2 months / 6+2 months / 12+2 months
|
|
Quality of Life
Time Frame: 2 months / 6+2 months / 12+2 months
|
WHOQoL
|
2 months / 6+2 months / 12+2 months
|
|
Instrumental Activities of daily living
Time Frame: 2 months / 6+2 months / 12+2 months
|
IADL
|
2 months / 6+2 months / 12+2 months
|
|
Depressive symptoms
Time Frame: 2 months / 6+2 months / 12+2 months
|
GDS
|
2 months / 6+2 months / 12+2 months
|
|
Brain function
Time Frame: 2 months
|
changes in abnormal brain waves that correlate with mild cognitive decline and dementia as measured by EEG and/or ERPs; changes in resting state networks; localisation of brain region activations/de-activations
|
2 months
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Collaborators
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
General Publications
- Bamidis PD, Vivas AB, Styliadis C, Frantzidis C, Klados M, Schlee W, Siountas A, Papageorgiou SG. A review of physical and cognitive interventions in aging. Neurosci Biobehav Rev. 2014 Jul;44:206-20. doi: 10.1016/j.neubiorev.2014.03.019. Epub 2014 Apr 4.
- Ladas A, Frantzidis C, Bamidis P, Vivas AB. Eye Blink Rate as a biological marker of Mild Cognitive Impairment. Int J Psychophysiol. 2014 Jul;93(1):12-6. doi: 10.1016/j.ijpsycho.2013.07.010. Epub 2013 Aug 1.
- Frantzidis CA, Vivas AB, Tsolaki A, Klados MA, Tsolaki M, Bamidis PD. Functional disorganization of small-world brain networks in mild Alzheimer's Disease and amnestic Mild Cognitive Impairment: an EEG study using Relative Wavelet Entropy (RWE). Front Aging Neurosci. 2014 Aug 26;6:224. doi: 10.3389/fnagi.2014.00224. eCollection 2014.
- Frantzidis CA, Ladas AK, Vivas AB, Tsolaki M, Bamidis PD. Cognitive and physical training for the elderly: evaluating outcome efficacy by means of neurophysiological synchronization. Int J Psychophysiol. 2014 Jul;93(1):1-11. doi: 10.1016/j.ijpsycho.2014.01.007. Epub 2014 Jan 25.
- Klados MA, Styliadis C, Frantzidis CA, Paraskevopoulos E, Bamidis PD. Beta-Band Functional Connectivity is Reorganized in Mild Cognitive Impairment after Combined Computerized Physical and Cognitive Training. Front Neurosci. 2016 Feb 29;10:55. doi: 10.3389/fnins.2016.00055. eCollection 2016.
- Styliadis C, Kartsidis P, Paraskevopoulos E, Ioannides AA, Bamidis PD. Neuroplastic effects of combined computerized physical and cognitive training in elderly individuals at risk for dementia: an eLORETA controlled study on resting states. Neural Plast. 2015;2015:172192. doi: 10.1155/2015/172192. Epub 2015 Apr 7.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
November 1, 2010
Primary Completion (Actual)
May 1, 2012
Study Completion (Actual)
April 1, 2013
Study Registration Dates
First Submitted
December 8, 2014
First Submitted That Met QC Criteria
December 8, 2014
First Posted (Estimate)
December 10, 2014
Study Record Updates
Last Update Posted (Estimate)
December 11, 2014
Last Update Submitted That Met QC Criteria
December 10, 2014
Last Verified
December 1, 2014
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 84171-A
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