Neuromuscular Control in Knee Osteoarthritis (NEKO)

March 2, 2015 updated by: Martijn Steultjens
Arthritis is one of the most prevailing causes of disability with knee osteoarthritis (KOA) the most common form. The lifetime risk of developing symptomatic KOA by the age of 85 years is 44.7%, where females are at a greater risk (1.8 times) than male counter parts. KOA is the leading cause of limitations in activities of daily living such as walking and climbing stairs particularly in the elderly. This is primarily due to pain and instability of the joint resulting in buckling of knees caused by muscle weakness, joint stiffness and damage. Patients with KOA have larger variations in muscle strength and are unable to maintain a target force combined with impaired ability to perceive joint movement and positioning suggests impaired neuromuscular control (NC) may influence KOA. NC refers to the nervous system's control over muscle activation contributing to task performance. This study aims to establish the role of loss of NC in biomechanical determinants and health outcomes of KOA.

Study Overview

Status

Completed

Conditions

Study Type

Observational

Enrollment (Actual)

95

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

      • Glasgow, United Kingdom, G4 0BA
        • Glasgow Caledonian University

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

40 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

All

Sampling Method

Non-Probability Sample

Study Population

Primary and secondary care clinics, and general community.

Description

Inclusion Criteria:

Knee osteoarthritis participants only:

  • Knee Osteoarthritis confirmed by a physician using the American College of Rheumatology (ACR 1986) Criteria
  • Have unilateral or bilateral knee osteoarthritis
  • Aged 40 years or over.

Healthy control participants only:

  • Have no history of unilateral/bilateral knee osteoarthritis
  • Had no current chronic/stable knee pain in the past 3 months
  • Aged 40 years or over.

Exclusion Criteria:

All participants are excluded if they:

  • Have neuromuscular skeletal injury/illness (e.g.Multiple Sclerosis, Parkinson's disease, Muscular Dystrophy, Cerebral Palsy)
  • Have had knee surgery, knee arthroplastic surgery and arthroscopic debridement or corrective surgery for knee osteoarthritis in the past 12 months
  • Have had corticosteroid injections to or around the knee in the past 3 months.
  • Have unstable heart disease
  • Previously had a stroke
  • Have insulin-dependent diabetes
  • Have osteoporosis
  • Have a history of falls and other motor deficits
  • Are unable to walk up and down stairs
  • Are unable to rise from a chair without the aid of another person
  • Have an unstable medication schedule and medication that causes dizziness
  • Have Dementia/Alzheimer's/ an inability to comprehend, follow instructions and give informed consent
  • Have an inability to lie flat for 60 minutes Have mental in their body.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Knee Osteoarthritis
Participants with diagnosed knee osteoarthritis
Controls
Participants without knee osteoarthritis

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Neuromuscular Control
Time Frame: 1 day
Neuromuscular control will be assessed through muscle co-activation index from electromyography (EMG) of the hamstrings, quadriceps and gastrocnemius. The electromechanical delay (delay between the onset of EMG and force), active proprioception and force accuracy and steadiness measure determined from submaximal isometric contractions will be used to determine neuromuscular control
1 day

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Disease Outcome
Time Frame: 1 day
Joint damage scored using the Boston Leeds Osteoarthritis Knee Score (BLOKS) from 1.5T MRI along with pain and function assessed from knee injury and osteoarthritis score (KOOS) and patient reported outcomes measurement information system (PROMIS) will be used to determine disease outcome.
1 day

Other Outcome Measures

Outcome Measure
Measure Description
Time Frame
Determinants of knee osteoarthritis
Time Frame: 1 day
Muscle strength (peak force) will be assessed from maximal isometric contractions of the knee, along with passive motion and position sense proprioception as determinants of knee osteoarthritis.
1 day

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Investigators

  • Principal Investigator: Stephanie L Smith, MRes, Glasgow Caledonian University

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

November 1, 2013

Primary Completion (Actual)

February 1, 2015

Study Completion (Actual)

February 1, 2015

Study Registration Dates

First Submitted

December 2, 2014

First Submitted That Met QC Criteria

December 9, 2014

First Posted (Estimate)

December 11, 2014

Study Record Updates

Last Update Posted (Estimate)

March 3, 2015

Last Update Submitted That Met QC Criteria

March 2, 2015

Last Verified

March 1, 2015

More Information

Terms related to this study

Other Study ID Numbers

  • GCU_MSK_SS_001

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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