Research on Mechanism of Massage Therapy on Energy Metabolism Disorder of Simple Obesity

This project is to penetrate and consummate the research mechanism of massage therapy on simple obesity. Latest researches indicate that the energy regulation network system of hypothalamus and metabolic disorders on adipocyte may be the pathological bases which result in obesity. The research group have firstly conducted effect studies of massage therapy on model of simple obesity rats and observed some neurobiological mechanism (whole effect mechanism), meanwhile, the team have discussed influences on the development of preadipocyte and function of endocrine with dynamic mechanical stimulation in vitro (local effect mechanism). This research aims at centering on the hypothesis that massage therapy can act on energy regulation network system of hypothalamus specifically, thus regulating the energy metabolic disorders. Then applying functional magnetic resonance imaging (fMRI) to explore whether patients with simple obesity exist abnormality on energy regulation network system of hypothalamus, ascertain mechanisms how massage therapy treat energy metabolism disorders of simple obesity, deepen mechanism study on how massage therapy prevent and treat obesity and enrich the clinical application's scientific connotation that massage therapy treat simple obesity.

Study Overview

• Status: Completed
• Conditions: Simple Obesity
• Intervention / Treatment: Other: Massage therapy

Detailed Description

This project will divide in two groups,healthy volunteers and obesity group.Healthy volunteers do not accept any treatment while obesity group need accept massage therapy three times a week,18 times in total.And two groups will be checked by functional magnetic resonance imaging (fMRI), Healthy volunteers for once and obesity group for twice(before treatment, obesity group's image of fMRI will compare with Healthy volunteers' and the image which is taken after treatment)

• Study Type: Interventional
• Enrollment (Actual): 38
• Phase: Not Applicable

Contacts and Locations

Study Locations

• China
  • Guizhou
    • Gui Yang, Guizhou, China, 550001
      • Guiyang College of Troditional Chinese Medicine

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 14 years to 56 years (Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

1.above 20% of the normal weight;BMI≥25.0；F%≥30%;

2.18-60 years old；

3.Patients agreeing and signing the Informed Consent for the study．

Exclusion Criteria:

1. The individuals do not adhere to the treatment or are with other treatments.
2. Secondary obesity, eg:pituitary diseases, hypothalamic disorder, hypothyroidism, pancreatic diseases，hyperadrenocorticism, postmenopausal obesity etc.
3. Having therapy for obesity in the last two weeks.
4. The individuals with server cardiovascular and cerebrovascular diseases and cancer.
5. Critical patients or patients combined with liver and kidney damage.
6. Individuals with psychosis.
7. Female individuals with pregnancy, lactation and planning a pregnancy in the two months.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Basic Science
• Allocation: Randomized
• Interventional Model: Single Group Assignment
• Masking: None (Open Label)

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
No Intervention: Healthy volunteers; Healthy volunteers'hypothalamus picture of fMRI will compare with Obesity group' , no intervention and remaining unchanged lifestyle.
Active Comparator: Obesity group; An intervention group of patients is put on a waiting list for massage therapy.Observing the Curative effect and hypothalamus picture of fMRI compare with healthy volunteers	Other: Massage therapy; Healthy volunteers do not accept treatment, just to be a control group to compare with obesity group

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
body mass index(BMI)	6 weeks after treatment

Secondary Outcome Measures

Outcome Measure	Time Frame
Body Weight	6 weeks after treatment
waistline	6 weeks after treatment
hip line	6 weeks after treatment
thigh line	6 weeks after treatment
percentage of body fat	6 weeks after treatment

Other Outcome Measures

Outcome Measure	Time Frame
image of hypothalamus of functional magnetic resonance imaging (fMRI)	before treatment and 6 weeks after treatment

Collaborators and Investigators

• Sponsor: Guiyang College of Traditional Chinese Medicine

Study record dates

Study Major Dates

• Study Start: July 1, 2015
• Primary Completion (Actual): January 1, 2016
• Study Completion (Actual): March 1, 2016

Study Registration Dates

• First Submitted: January 13, 2015
• First Submitted That Met QC Criteria: January 14, 2015
• First Posted (Estimate): January 15, 2015

Study Record Updates

• Last Update Posted (Actual): August 9, 2017
• Last Update Submitted That Met QC Criteria: August 8, 2017
• Last Verified: August 1, 2017

More Information

Terms related to this study

• Keywords: Massage therapy; Energy metabolism; Mechanism; Simple obesity
• Additional Relevant MeSH Terms: Overnutrition; Nutrition Disorders; Overweight; Body Weight; Obesity; Obesity, Morbid
• Other Study ID Numbers: 20141021