Optimal Low B-value in Intravoxel Incoherent Motion Diffusion-weighted MR Imaging of the Brain

Can the Distribution of Low B-value and the NEX Influence the Pseudodiffusion Parameter Derived From IVIM in Brain?

Our research aims to reveal whether the low b-values distribution and the number of NEX for each b value will influence the accuracy of pseudodiffusion parameter derived from IVIM in brain.

Study Overview

• Status: Completed
• Conditions: Healthy Volunteers
• Intervention / Treatment: Other: different low b-values distribution

Detailed Description

As an improved MRI technique, diffusion-weighted imaging (DWI) is considered the most sensitive for early pathological changes. Perfusion measurement has been shown to improve sensitivity and predictive value for tumor grading and prognosis, also as a predicator of recovery with reperfusion in patients of acute ischemic stroke.Our research aims to reveal whether the low b-values distribution and the number of NEX for each b value will influence the accuracy of pseudodiffusion parameter derived from IVIM in brain.

• Study Type: Observational
• Enrollment (Actual): 20

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 25 years to 35 years (Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: Male

• Sampling Method: Probability Sample

Study Population

healthy volunteers

Description

Inclusion Criteria:

• no hypertension or cerebral vascular diseases,
• no systemic metabolic disease;
• no infection or fever;
• no use of corticosteroid drugs;
• no MRI contraindication.

Exclusion Criteria:

Study Plan

How is the study designed?

Number of groups / cohorts

5

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Group 1; Low b=(0,50,150,200)，NEX=(1,3,2,2)	Other: different low b-values distribution
Group 2; Low b=(0,30,50,100,200)，NEX=(1,3,3,2,2)	Other: different low b-values distribution
Group 3; Low b=(0,30,60,90,120,150,180,200)，NEX=(1,3,3,3,2,2,2,2)	Other: different low b-values distribution
Group 4; Low b=(0,30,60,90,120,150,180,200)，NEX=(1,1,1,1,1,1,1,1)
Group 5; Low b=(0,20,40,60,80,100,120,140,160,180,200)NEX=(1,3,3,3,3,2,2	Other: different low b-values distribution

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Parameters D* and f in healthy white matter or gray mater	2-3 days

Collaborators and Investigators

• Sponsor: Tang-Du Hospital

Study record dates

Study Major Dates

• Study Start: November 1, 2014
• Primary Completion (Actual): December 1, 2014
• Study Completion (Actual): December 1, 2014

Study Registration Dates

• First Submitted: December 10, 2014
• First Submitted That Met QC Criteria: April 2, 2015
• First Posted (Estimate): April 8, 2015

Study Record Updates

• Last Update Posted (Actual): July 5, 2017
• Last Update Submitted That Met QC Criteria: July 2, 2017
• Last Verified: July 1, 2017

More Information

Terms related to this study

• Keywords: brain; diffusion-weighted imaging; IVIM
• Other Study ID Numbers: TDLL-20140570