Dental Extractions Among Renal Transplant Recipients

November 26, 2018 updated by: Marina Helena Cury Gallottini, University of Sao Paulo

Clinical Outcome of Dental Extractions Among Renal Transplant Recipients

The literature is rich in studies that explore the type and frequency of oral abnormalities in transplanted recipients, but it is scarce in studies that provide scientific evidence on the risk of complications after invasive interventions on those patients. Within this context, the aim of our study is to evaluate the post-exodontic socket healing in renal transplant recipients compared to a control group and see if some indicators in the population of transplanted people, such complete blood count, serum concentration of immunosuppressive drugs, can help to provide for the host response face a invasive procedures. Therefore, 45 kidney transplant recipients over six months and at least 45 healthy non immunosuppressed adults will be submitted to a maximum of 4 simple dental extractions, always by the same surgeon. Laboratory tests will be performed preoperatively and include: blood count and coagulation - for both groups - and urea, creatinine and serum levels of immunosuppressive drug - only for the study group. Researchers will evaluate the patient in the postoperative 3, 7, 21, and 60 days. The presence, or absence, of post-operative complication and delayed, or not, socket healing will be the results of interest in this study and will be compared between the groups. The data will be evaluated by Pearson's chi-square, Fisher's exact test, Mann-Whitney test, student's T-test and binomial test.

Study Overview

Status

Completed

Conditions

Detailed Description

Investigators did not found scientific evidences neither evidence-based research, which support the idea that stable kidney recipients have increased risk for delayed socket repair and wound healing after exodontia or that infections resulted by oral surgery are more common in these patients, despite the drug-induced immunosuppression which they use.

Since there is no scientific evidence about the increased risk of post-exodontic infection, not even about a disorder on the alveolar repair chronology, after exodontia performed in kidney recipients, the aim of our study will be prospectively observe kidney recipients who are undergoing dental extractions.

This prospective cohort study will involve 45 adult kidney recipients for at least 6 months, and 61 non-transplanted and healthy control adults, who need simple extraction of an erupted tooth.

All the patients must be evaluated in the preoperative phase through anamnesis (e.g. collecting data concerning on base diseases, personal history, presence of drug allergy, medications in use, habits and addictions), extra-oral and intra-oral physical examinations and laboratory tests.

Participants must sign the Inform and Clarified Consent Term to participate. Will be disqualified participants that: used antibiotics in the month preceding the extraction, made bisphosphonate therapy, user of illicit drugs, chronic alcoholics, who present with dental emergencies, acute dental or periodontal infections, and patients with cognitive impairment.

One week before the dental extraction will be collected 15ml of blood from participants of both group to perform complete blood count, coagulation tests, urea and creatinine measurements. The serum measurement of the immunosuppressed drug will be performed only in the individuals of study group.

Dental extractions, from one to three erupted teeth, will be performed by the same dentist, specialist in Oral and Maxillofacial Surgery, enabled by the Federal Council of Dentistry, on the ambulatory of CAPE (special care center) , under local anesthesia following the standards described by Peterson et al (2003). The local anesthetic used in all individuals will be prilocaine with epinephrine as vasoconstrictor. After the anesthetic blockade, incision and mucosal detachment, luxation with elevators and tooth removal with forceps will be performed. The surgical technique will be modified according the condition of the tooth on the socket; when necessary tooth sectioning and/or ostectomy will be performed. By the end, curettage of the socket, post-extraction alveolar compression to reduce the width of the same and simple suture with 4.0 silk thread will be carried out.

Each tooth characteristics and each surgery data will be recorded and will include: surgical duration (from the anesthesia to the suture), surgical technique variations, such the use of elevators, forceps, mucoperiosteal flaps, tooth sectioning and/or ostectomy and intraligamentary anesthesia, and number of anesthetics cartridges used.

After the surgery, the patient will press a gauze for 30 minutes in the extraction's region in order to control bleeding. It will be prescribed 750 mg of Acetominophen, up to 3 times a day, for 24 hours. In case of necessity of change in the postoperative therapeutic due to surgical technique variations, data will be recorded and included.

Clinical assessment of healing will be performed by a blinded examiner on 3, 7, 21 and 60 days after surgery. In these periods, the region will always be examined by the same examiner.

Radiographic evaluation will be done with standardized periapical radiographs, with individualized positioners, made in the immediately and 60 days postoperative, which bone density and alveolar crest remodeling will be evaluated by a blinded examiner.

With 21 days postoperative, the socket will be classified as: 1) without complication; or 2) with complications. According to Cheung et al (2001), the following situations will be considered as post-exodontics complications:

Acute alveolar infection (dry socket, fibrinolytic osteitis, alveolar osteitis) or surrounding tissue infection Acute alveolar inflammation.

In case of postoperatively infection, copious irrigation with sodium chloride solution (NaCl 0,9%) will be performed and will be prescribed amoxicilline 500 mg every 8 hours for 7 days and anti-inflammatory nimesulide 100 mg every 12 hours for 5 days. In case of allergy to penicillin, clindamycin will be prescribed at a dose of 300 mg every 8 hours for 7 days.

The second outcome of interest in this study will be observe the total alveolar epithelialization. According to the literature, at 3 days postoperative, the socket is filled with blood clot and fibrin; at 7 days, the socket is filled with granulation tissue; and from 21 days the surgical wound is fully epithelialized. Delayed epithelialization will be considered in case at on the day 21, the socket would not yet fully covered by epithelialized mucosa.

Finally, the third point will be the bone deposition in the socket, at 60 days postoperative.

All data will be transferred to an Excel spreadsheet and analyzed descriptively and associated with each other. Complications will be compared between the two groups. In addition, in the study group, researchers will investigate the occurrence of complications associated with transplantation time, immunosuppressive dose, and presence of comorbidity, such as diabetes.

Exact Fisher's test or Fisher's exact test will be applied, Mann-Whitney's test or Student's T-test and binomial test using the R software, version 2.15.3 (R Development Core Team, 2012). The significance level will be set at 5%. Adjustments to modifying factors such as smoking and presence of diabetes will be analyzed by logistic regression.

Study Type

Observational

Enrollment (Actual)

106

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Brazil
      • São Paulo, Brazil, 05508-000
        • University of Sao Paulo
    • SP
      • São Paulo, SP, Brazil, 05508000
        • Rubens Caliento

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years and older (ADULT, OLDER_ADULT)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

All

Sampling Method

Non-Probability Sample

Study Population

kidney transplanted individuals requiring extraction of erupetd teeth

Description

Inclusion Criteria:

  • renal transplantation for more than 6 months

Exclusion Criteria:

  • use of antibiotic in the previous month, use of bisphosphonate therapy, use of illicit drugs, chronic use of alcohol, having a dental emergency,having acute dental or periodontal infections, having a cognitive impairment.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Transplanted group
patients who are kidney receptors for at least 6 months and need tooth extraction
Control group
healthy patients who need tooth extraction

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Complication
Time Frame: 21 days
alveolar healing will be classified in complicated or non-complicated, based on the conditions and symptoms of soft tissue healing
21 days

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Delayed alveolar healing
Time Frame: 60 days
alveolar healing will be classified in normal or delayed healing based on the chronology of alveolar and soft tissue healing
60 days

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University of Sao Paulo

Collaborators

Fundação de Amparo à Pesquisa do Estado de São Paulo
Federal University of São Paulo
Hospital do Rim e Hipertensão

Investigators

  • Principal Investigator: Marina Gallottini, University of Sao Paulo

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

October 1, 2015

Primary Completion (Actual)

July 1, 2018

Study Completion (Actual)

August 31, 2018

Study Registration Dates

First Submitted

September 9, 2015

First Submitted That Met QC Criteria

September 9, 2015

First Posted (Estimate)

September 11, 2015

Study Record Updates

Last Update Posted (Actual)

November 28, 2018

Last Update Submitted That Met QC Criteria

November 26, 2018

Last Verified

November 1, 2018

More Information

Terms related to this study

Keywords

Other Study ID Numbers

  • CAAE: 45413015.0.0000.0075

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

YES

IPD Plan Description

All the data will be available after the end of study

IPD Sharing Time Frame

Immediately after the end of the study

IPD Sharing Access Criteria

General public

IPD Sharing Supporting Information Type

  • STUDY_PROTOCOL

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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