Glucose and Fructose Stimulated Brain Activity in Obese Subjects

Effects of Acute Glucose and Fructose Ingestion on Brain Activity in Obese Volunteers

The objective is to investigate neuro-anatomical correlates of the regulation of energy intake by means of functional MRI. Administration of glucose as well as fructose is followed by functional brain MRI, and findings are correlated with serum glucagon-like peptide 1 (GLP-1) levels as an endogenous satiety signal in obese humans.

Study Overview

• Status: Completed
• Conditions: Exploratory Behavior
• Intervention / Treatment: Dietary supplement: tap water; Dietary supplement: Glucose; Dietary supplement: Fructose

• Study Type: Interventional
• Enrollment (Actual): 12
• Phase: Not Applicable

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 45 years (Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: Male

Description

Inclusion Criteria:

• right-handed healthy males, no drugs, non-smoking

Exclusion Criteria:

• drug abuse, smoker, left-handed, claustrophobia

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Prevention
• Allocation: Randomized
• Interventional Model: Crossover Assignment
• Masking: Double

Number of Arms

3

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Placebo Comparator: PLACEBO; Single intragastric instillation of 300ml tap water via nasogastric tube	Dietary supplement: tap water; 300ml tap water via nasogastric tube
Active Comparator: GLUCOSE; Single intragastric instillation of 75g Glucose in 300ml tap water via nasogastric tube	Dietary supplement: Glucose; 300ml tap water with 75g Glucose via nasogastric tube
Active Comparator: FRUCTOSE; Single intragastric instillation of 25g Fructose in 300ml tap water via nasogastric tube	Dietary supplement: Fructose; 300ml tap water with 25g Fructose via nasogastric tube

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Functional magnetic resonance imaging (fMRI) in healthy, obese volunteers while they performed a working memory task: changes in cerebral blood flow	changes from baseline to one hour after treatment

Secondary Outcome Measures

Outcome Measure	Time Frame
Changes in plasma insulin	changes from baseline to one hour after treatment
Changes in plasma glucose	changes from baseline to one hour after treatment
Changes in plasma GLP-1	changes from baseline to one hour after treatment

Collaborators and Investigators

• Sponsor: University Hospital, Basel, Switzerland
• Investigators: Study Chair: Christoph Beglinger, MD, University of Basel

Study record dates

Study Major Dates

• Study Start: October 1, 2013
• Primary Completion (Actual): June 1, 2014
• Study Completion (Actual): June 1, 2014

Study Registration Dates

• First Submitted: October 20, 2015
• First Submitted That Met QC Criteria: October 26, 2015
• First Posted (Estimate): October 28, 2015

Study Record Updates

• Last Update Posted (Estimate): October 28, 2015
• Last Update Submitted That Met QC Criteria: October 26, 2015
• Last Verified: October 1, 2015

More Information

Terms related to this study

• Other Study ID Numbers: fMRI Obese