Molecular and Imaging Studies of Cardiovascular Health and Disease (Biobank)

June 14, 2016 updated by: National Heart Centre Singapore
Biobank is a program which collects biological samples, health information and imaging data from consented patients and stored them at the core facility. These information would be used to study the molecular, imaging and outcome studies of cardiovascular health and disease.

Study Overview

Status

Recruiting

Conditions

Intervention / Treatment

Detailed Description

This program recruits patient from National Heart Centre Singapore and collects their biological sample, health information and imaging data.The donated biospecimens will be stored indefinitely and used for any future research on molecular, imaging and outcome studies of cardiovascular health and disease.The same biological samples and imaging data will be obtained from consented healthy volunteers for comparison.

Study Type

Observational

Enrollment (Anticipated)

5000

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Contact Backup

  • Name: Stuart Cook, MBBS, PhD

Study Locations

  • Singapore
      • Singapore, Singapore, 169609
        • Recruiting
        • National Heart Centre Singapore

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

16 years to 90 years (Child, Adult, Older Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Sampling Method

Non-Probability Sample

Study Population

Patient will be recruited from primary care clinic and outpatient clinics from the National Heart Centre Singapore. For healthy volunteer, they will be recruited through poster and advertisement.

Description

There is no inclusion/exclusion criteria except for the age limit as this is a repository program.

Inclusion Criteria:

•Subject aged ≥ 16 years and ≤ 90 years.

Exclusion Criteria:

•No

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Observational Models: Cohort
  • Time Perspectives: Prospective

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
Healthy Volunteer
Subjects will undergo the following study procedure: Cardiovascular Magnetic Resonance Imaging and fatmass measurement
Other: Cardiovascular Magnetic Resonance
For the evaluation of heart function and structure of the cardiovascular system.
Other: Fatmass measurement
It utilizes a scale machine to measure the body fat and skeletal muscle percentage
Dilated Cardiomyopathy
Subjects will undergo the following study procedure: Cardiovascular Magnetic Resonance Imaging and fatmass measurement
Other: Cardiovascular Magnetic Resonance
For the evaluation of heart function and structure of the cardiovascular system.
Other: Fatmass measurement
It utilizes a scale machine to measure the body fat and skeletal muscle percentage
Hypertrophic cardiomyopathy
Subjects will undergo the following study procedure: Cardiovascular Magnetic Resonance Imaging and fatmass measurement
Other: Cardiovascular Magnetic Resonance
For the evaluation of heart function and structure of the cardiovascular system.
Other: Fatmass measurement
It utilizes a scale machine to measure the body fat and skeletal muscle percentage
Ischemic heart disease with reduced EF
Subjects will undergo the following study procedure: Cardiovascular Magnetic Resonance Imaging and fatmass measurement
Other: Cardiovascular Magnetic Resonance
For the evaluation of heart function and structure of the cardiovascular system.
Other: Fatmass measurement
It utilizes a scale machine to measure the body fat and skeletal muscle percentage
Ischemic heart disease with normal EF
Subjects will undergo the following study procedure: Cardiovascular Magnetic Resonance Imaging and fatmass measurement
Other: Cardiovascular Magnetic Resonance
For the evaluation of heart function and structure of the cardiovascular system.
Other: Fatmass measurement
It utilizes a scale machine to measure the body fat and skeletal muscle percentage

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Numbers of genetic variation in genes known to cause inherited cardiac condition and circulating biomarkers which are linked with DNA changes using advanced sequencing and informatics approaches
Time Frame: 10 years
10 years

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

National Heart Centre Singapore

Investigators

  • Principal Investigator: Stuart Cook, MBBS,PhD, National Heart Centre Singapore

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

July 1, 2013

Primary Completion (Anticipated)

July 1, 2033

Study Completion (Anticipated)

July 1, 2033

Study Registration Dates

First Submitted

May 31, 2016

First Submitted That Met QC Criteria

June 14, 2016

First Posted (Estimate)

June 17, 2016

Study Record Updates

Last Update Posted (Estimate)

June 17, 2016

Last Update Submitted That Met QC Criteria

June 14, 2016

Last Verified

July 1, 2013

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 2013/605/C

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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