The Association Between Nephrolithiasis and Periodontal Status

The Association Between Nephrolithiasis and Periodontal Status

Sponsors

Lead sponsor: Rambam Health Care Campus

Source Rambam Health Care Campus
Brief Summary

Dental calculus is a calcified deposits firmly attached to teeth and implants surfaces. Dental calculus is strongly associated with periodontitis and considered to have indirect role in the pathogenesis of periodontal diseases. Dental calculus composed primarily of calcium phosphate mineral salts originated in the saliva covered by unmineralized bacterial layer. Composition of calculus varies from person to person and influenced by numerous variables such as: age, gender systemic disease and ethnic background.

Nephrolithiasis (kidney stones) are composed of insoluble salts of constituents of the forming urine. The most two frequent stone types are: Calcium oxalate (with a frequency of 15% -35%) and Calcium phosphate (5% -20%). The prevalence of kidney stones varies with race, sex, and geographic location. In the United States for men, kidney stone rates vary between 4%-9%, and for women, kidney stone rates range between 2%-4%.

Previous studies dealt with the connection between sialolithiasis and nephrolithiasis were inconclusive. To the authors' best knowledge no studies were done to examine the associations between nephrolithiasis and dental calculus. Thus, the aim of this study is to compare the mineral composition of both dental calculus and nephrolithiasis and determine whether nephrolithiasis composition may be linked to the periodontal status.

Overall Status Unknown status
Start Date May 11, 2017
Completion Date January 2019
Primary Completion Date December 2018
Study Type Observational
Primary Outcome
Measure Time Frame
the composition of both specimens the analysis will take 9 months
Enrollment 20
Condition
Intervention

Intervention type: Procedure

Intervention name: Scaling

Description: Scaling of dental calculus

Eligibility

Sampling method: Non-Probability Sample

Criteria:

Inclusion Criteria:

- Patients diagnosed with nephrolithiasis

- Over 18 years old

Exclusion Criteria:

- Pregnant woman, uncontrolled diabetes (HbA1c > 7.5%), patients who received periodontal treatment in the past 6 months, smokers

Gender: All

Minimum age: 18 Years

Maximum age: N/A

Healthy volunteers: No

Location
facility status contact Rambam Health Care Campus, Dept. of Periodontology prof. Eli Machtei, DMD 9720545503199 [email protected]
Location Countries

Israel

Verification Date

March 2018

Responsible Party

Responsible party type: Principal Investigator

Investigator affiliation: Rambam Health Care Campus

Investigator full name: machtei

Investigator title: Prof

Has Expanded Access No
Condition Browse
Patient Data No
Study Design Info

Observational model: Case-Only

Time perspective: Cross-Sectional

Source: ClinicalTrials.gov