- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03148977
Evaluating MMPs in Burns
March 23, 2021 updated by: University of Florida
Evaluating a Point-of-Care, Quantitative Matrix Metalloproteinase Assay as a Predictor of Successful Graft Take in Patients Undergoing Cutaneous Auto Grafting for Acute Burn Injury- A Pilot Study
The objective of this study is to determine whether our chemical assay can be used to reliably predict graft take or failure in patients undergoing autologous skin grafting for treatment of acute burn injury.
Study Overview
Status
Terminated
Conditions
Intervention / Treatment
Detailed Description
This is an observational pilot study of patients treated at UF Health Shands Burn Center adult service.
This is a study to determine the predictive value of quantifying concentrations of specific MMPs.
Coupling this with a specialized collection sample collection system and a calibrated fluorimetry allows for the rapid assessment of MMP concentrations.
This assay has been validated as a predictor of failed wound healing in a published clinical study involving chronic open wounds.
Study Type
Observational
Enrollment (Actual)
8
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
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Florida
-
Gainesville, Florida, United States, 32608
- UF Health Cancer Hospital
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Gainesville, Florida, United States, 32610
- UF Health Shands at the University of Florida
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years to 98 years (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Sampling Method
Probability Sample
Study Population
Adult burn patients admitted
Description
Inclusion Criteria:
- 18 years of age or older
- Admitted with acute burns injuries (flame, contact or scald) requiring at least one surgical excision and grafting operation will be considered for inclusion
- Burn injury less than one week old
Exclusion Criteria:
- Electrical, chemical or cold-induced burn injury
- Total body surface area burn >50 %
- Pre injury diagnosis of chronic renal insufficiency, liver failure, refusal to accept blood transfusion or withdrawal of care within three days of admission will also be exclusion criteria
- Patients not expected to survive
- Patients presenting with re-injury to previously burned and treated areas.
- Patients who present after receiving burn excision surgery out an outside facility for the current acute injury
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
---|---|
Patients admitted to the burn center
Patients admitted to the Burn Service with acute burn injuries requiring at least one surgical excision and grafting operation.
|
Autogenous skin grafting is the only definitive treatment for the full thickness burn injuries, and thus represents the centerpiece of modern burn care.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Predictability of graft take
Time Frame: 2 years
|
Determine whether chemical assay can be used to reliably predict graft take or failure in patients undergoing autologous skin grafting for treatment of acute burn injury.
|
2 years
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Wound healing
Time Frame: 2 years
|
Assess the predictive value of serial MMP assays in identifying wounds transitioning from likely-to-fail to likely-to-succeed
|
2 years
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Investigators
- Principal Investigator: Joshua S. Carson, MD, University of Florida
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
June 9, 2017
Primary Completion (Actual)
December 8, 2020
Study Completion (Actual)
December 8, 2020
Study Registration Dates
First Submitted
May 9, 2017
First Submitted That Met QC Criteria
May 9, 2017
First Posted (Actual)
May 11, 2017
Study Record Updates
Last Update Posted (Actual)
March 26, 2021
Last Update Submitted That Met QC Criteria
March 23, 2021
Last Verified
March 1, 2021
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- IRB201602508
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
NO
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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