- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03161821
Circulating Tumor Cells in Solid Tumors
September 27, 2022 updated by: UNC Lineberger Comprehensive Cancer Center
Quantification and Characterization of Circulating Tumor Cells in Solid Tumors
The purpose of this study is to identify circulating tumor cells in patients with solid tumors.
Quantify and characterize these cells, collect patient information in regards to the patient's cancer.
Develop a database and a sample repository where future analysis could be done.
Study Overview
Detailed Description
The primary purpose of this correlative study is to create a prospective database documenting the quantity and characterization of circulating tumor cells (CTCs) in solid tumor patients as identified by a various laboratory techniques and analyses.
The investigators are developing this resource to provide data to achieve the following objectives: 1) correlate CTCs with known prognostic factors, 2) correlate CTCs with burden of disease, 3) evaluate the ability of CTCs to be used in the surveillance of disease recurrence, and 4) evaluate CTCs ability to be used as a biomarker for treatment response.
Study Type
Observational
Enrollment (Actual)
206
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
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North Carolina
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Chapel Hill, North Carolina, United States, 27599
- Radiation Oncology Clinic - UNC Cancer Hospital
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years and older (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Sampling Method
Probability Sample
Study Population
Patients with cancerous solid tumors
Description
Inclusion Criteria:
- Age ≥ 18 years of age
- Biopsy proven solid tumor malignancy
- Seen at UNC Chapel Hill Hospital and Health Care System
- Consents to abstraction of their medical records
- Signed an institutional review board (IRB)-approved informed consent document for this protocol
Exclusion Criteria:
- < 18 years of age
- Dementia, altered mental status, incarceration or any psychiatric condition that would prohibit the understanding or rendering of informed consent.
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Documentation of the Quality of CTCs from Patients with Solid Tumors
Time Frame: Through study completion, an average of 5 years
|
Enumeration of participants' circulating solid tumor cells
|
Through study completion, an average of 5 years
|
Documentation of the Characterization of CTCs from Patients with Solid Tumors
Time Frame: Through study completion, an average of 5 years
|
Characterization of participants' circulating solid tumor cells
|
Through study completion, an average of 5 years
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Investigators
- Principal Investigator: Lisa A Carey, MD, University of North Carolina
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
December 9, 2011
Primary Completion (Actual)
February 16, 2021
Study Completion (Actual)
February 16, 2021
Study Registration Dates
First Submitted
May 15, 2017
First Submitted That Met QC Criteria
May 18, 2017
First Posted (Actual)
May 22, 2017
Study Record Updates
Last Update Posted (Actual)
September 28, 2022
Last Update Submitted That Met QC Criteria
September 27, 2022
Last Verified
September 1, 2022
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- LCCC 1121
- 11-1924 (Other Identifier: UNC IRB)
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
NO
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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