Acute-On-Chronic Liver Failure in Zagazig University Hospitals (ACLF)

August 12, 2018 updated by: salem youssef mohamed, Zagazig University

ACLF in Zagazig University Hospitals

Rationale:

To identify the prevalence of Acute-on-chronic liver failure in Zagazig University Hospitals.

The question of the research:

How much the prevalence of Acute-on-chronic Liver Failure in Zagazig University Hospitals?

The aim of the work:

The aim of the study is to identify the presence of Acute-on-chronic Liver Failure in Zagazig University Hospitals

Objectives:

To estimate the prevalence of Acute-on-chronic Liver Failure in Zagazig University Hospitals.

Subjects and Methods:

I . Technical Design:

  • Site of the study: Gastroenterology and Hepatology Unit- Zagazig University Hospitals
  • Sample size: ''all patients admitted to Gastroenterology and Hepatology Unit with the criteria of ACLF according to EASL-AASLD from June 2017 to December 2017 were included in this study''.

II . OPERATIONAL DESIGN:

  • Type of the study: a prospective study.
  • Full medical history - taking.
  • Full clinical examination.
  • Laboratory investigations including Routine laboratory investigation " CBC, Liver functions test, kidney functions test and prothrombin time "

III. Administrative Design:

  • Approvals obtained for performing the study from the official or governmental department.
  • An ethical committee from the faculty of medicine and patients included in the study.

Results:

Collected data will be presented in tables and suitable graphs and analyzed according to standard statistical methods

Study Overview

Status

Completed

Conditions

Study Type

Observational

Enrollment (Actual)

300

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Egypt
    • Sharqia
      • Zagazig, Sharqia, Egypt, 44519
        • Salem Mohamed

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Child
  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Sampling Method

Probability Sample

Study Population

All patients admitted to Gastroenterology and Hepatology Unit with the criteria of ACLF according to EASL-AASLD will be included in this study.

Description

Inclusion Criteria:

  • all patients admitted to Gastroenterology and Hepatology Unit with the criteria of ACLF according to EASL-AASLD will be included in this study.

Exclusion Criteria:

  • no any exclusion criteria

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
improvement of the patients score according to SOFA score (AASLD and EASL guidelines)
Time Frame: 24 weeks from first recruiting
follow up of participants until the patients recover
24 weeks from first recruiting

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
death of the patient
Time Frame: 24 weeks from first recruiting
due to the severity of acute on chronic failure, the death of patients is expected
24 weeks from first recruiting

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Zagazig University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

July 1, 2017

Primary Completion (Actual)

August 11, 2018

Study Completion (Actual)

August 11, 2018

Study Registration Dates

First Submitted

June 7, 2017

First Submitted That Met QC Criteria

June 9, 2017

First Posted (Actual)

June 12, 2017

Study Record Updates

Last Update Posted (Actual)

August 14, 2018

Last Update Submitted That Met QC Criteria

August 12, 2018

Last Verified

August 1, 2018

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • acute on chronic liver failure

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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