Recovery of Impairments Early After Stroke (aRISE)

February 6, 2020 updated by: University of Zurich

Upper limb recovery after stroke is highly predictable early after stroke. Nijland et al. showed that based on two simple clinical bedside tests - 'Shoulder Abduction' and 'Finger Extension' (the so called 'SAFE model' [Stinear et al., 2012]) - measured within the first 72 hours after stroke, ~87% of the patients could be correctly classified as either regaining or not regaining some dexterity (recoverers or nonrecoverers, respectively) (Nijland et al., 2010). This kind of information regarding the patients' functional prognosis allows proper discharge planning, setting realistic rehabilitation goals, and adequate patient information. However, the length of hospital stay after stroke has been decreasing. Therefore, knowledge is needed regarding the ability to make an accurate first prediction within the first 24 hours after stroke onset while using simple clinical bedside assessments. This would facilitate an earlier triage and with that, an accelerated and smooth transition of patients within the stroke care continuum. In addition, a first prediction within 24 hours poststroke has the potential to decrease health care expenses, as length of hospital stay after an acute stroke is ~30% of the total costs (i.e., direct and indirect costs) associated with stroke (Roger et al., 2012; Fattore et al., 2012).

The primary objective of aRISE is to determine the ability of the behavioral biometric impairments 'Shoulder Abduction' and 'Finger Extension' measured <24 hours poststroke to predict outcome of upper limb capacity 3 months after stroke. The secondary aim is to investigate the the added value of other simple clinical bedside tests for predicting outcome of upper limb capacity 3 months poststroke.

aRISE is a prospective longitudinal observational cohort study of 40 first-ever ischemic stroke patients, who will be assessed <24 hours, 7 days and 3 months after stroke onset.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Observational

Enrollment (Actual)

40

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Switzerland
      • Zurich, Switzerland, 8091
        • University of Zurich

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Sampling Method

Non-Probability Sample

Study Population

First-ever unilateral ischemic stroke patients, admitted to hospital

Description

Inclusion Criteria:

  • First-ever unilateral ischemic stroke in the middle cerebral artery territory <48 hours, confirmed by MRI-DWI and/or CT
  • Age 18 years or older
  • Able to follow one-staged commands
  • NIHSS arm score ≥1
  • Informed consent after participants' information

Exclusion Criteria:

  • Modified Rankin Scale score >2 before stroke
  • Neurological or other diseases affecting the upper limb(s) before stroke
  • Intravenous line in the upper limb(s) which limits assessment
  • Contra-indications on ethical grounds
  • Expected or known non-compliance to participate in the observational study, severe drug or/and alcohol abuse

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Observational Models: Cohort
  • Time Perspectives: Prospective

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
Single-group study
Assessment of behavioral biometric impairments
Behavioral: Assessment of behavioral biometric impairments
Assessment of behavioral biometric impairments

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Action Research Arm Test
Time Frame: 3 months poststroke
Upper limb capacity
3 months poststroke
Fugl-Meyer Assessment
Time Frame: 3 months poststroke
Upper limb motor function
3 months poststroke
Motricity Index
Time Frame: 3 months poststroke
Upper limb motor function
3 months poststroke

Other Outcome Measures

Outcome Measure
Measure Description
Time Frame
Surface Electromyography
Time Frame: 48 hours, 7 days, and 3 months poststroke
Forearm skeletal muscle electric activity
48 hours, 7 days, and 3 months poststroke
Movement Sensors
Time Frame: 48 hours, 7 days, and 3 months poststroke
Upper limb range of motion patterns
48 hours, 7 days, and 3 months poststroke
National Institutes of Health Stroke Scale
Time Frame: 48 hours, 7 days, and 3 months poststroke
Neurological functions
48 hours, 7 days, and 3 months poststroke
Trunk Control Test
Time Frame: 48 hours, 7 days, and 3 months poststroke
Sitting balance
48 hours, 7 days, and 3 months poststroke
Functional Ambulation Categories
Time Frame: 48 hours, 7 days, and 3 months poststroke
Walking ability (independence)
48 hours, 7 days, and 3 months poststroke
Modified Rankin Scale
Time Frame: 48 hours, 7 days, and 3 months poststroke
Global disability
48 hours, 7 days, and 3 months poststroke
Motor Activity Log - 14
Time Frame: 48 hours, 7 days, and 3 months poststroke
Patient-reported daily life upper limb use
48 hours, 7 days, and 3 months poststroke
Global Rating of Perceived Changes
Time Frame: 3 months poststroke
3 months poststroke
Concomitant Movement Therapy
Time Frame: 48 hours, 7 days, and 3 months poststroke
Intensity of therapy based on charts
48 hours, 7 days, and 3 months poststroke
Safety
Time Frame: 48 hours, 7 days, and 3 months poststroke
Serious Events (1. death; 2. life-threatening illness or injury; 3. in-patient or prolonged hospitalisation; 4. medical or surgical intervention to prevent life threatening illness; 5. led to fetal distress, death or a congenital abnormality or birth defect)
48 hours, 7 days, and 3 months poststroke

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University of Zurich

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

October 15, 2017

Primary Completion (Actual)

January 30, 2020

Study Completion (Actual)

January 30, 2020

Study Registration Dates

First Submitted

September 12, 2017

First Submitted That Met QC Criteria

September 14, 2017

First Posted (Actual)

September 19, 2017

Study Record Updates

Last Update Posted (Actual)

February 10, 2020

Last Update Submitted That Met QC Criteria

February 6, 2020

Last Verified

February 1, 2020

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 2017-00889

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

No

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

product manufactured in and exported from the U.S.

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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