- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03452904
FrActional Flow Reserve Guided Drug Coated Balloon Only Strategy in De Novo coronarY Lesions (FADDY) (FADDY)
March 21, 2018 updated by: Second Affiliated Hospital, School of Medicine, Zhejiang University
The Randomized FADDY Study (FrActional Flow Reserve Guided Drug Coated Balloon Only Strategy in De Novo coronarY Lesions)
Drug-eluting stent (DES) has been the primary choice for in suit coronary lesions treatment.
In comparison to bare-metal stent (BMS), it evidently decreases the rate of restenosis.
However, in recent years in-stent restenosis or thrombogenesis caused by acquired stent malapposition in the late stage or by new in-stent atherosclerotic plaques was oberved, which possibly was associated with chronic inflammation stimulation because of residual intravascular metal or polymer coating.
Through being expanded around 30 to 60 seconds, drug-coated balloon (DCB) can ensure adequate paclitaxel enter the artery wall, which can inhibit smooth muscle cells hyperplasia without remaining any foreign body.
In recent small sample trials, they showed that sole DCB treatment had a good long-term effect when pre-treating ideal in suit coronary lesions (defined as residual stenosis< 30%, without dissection severer than type C, anterograde flow TIMI III).
In PEPCAD I trial, the rate of major adverse cardiovascular events (MACE) was 6.1% in the first 12 months and persistent to 3-year follow up.
Small sample prospective observational study from Korea, like Shin, showed that in the in suit coronary lesions with the fractional flow reserve (FFR)>0.85 after percutaneous transluminal coronary angioplasty (PTCA), the FFR kept unchanged in the 9-month follow up after DCB treatment and there was not MACE happened.
However, so far randomized controlled trials with large sample to confirm their non-inferiority compared with DES when treating relatively larger in suit coronary lesions are lacked.
Meanwhile, a number of doctors worried about acute cardiovascular occlusion and long-term restenosis.
In this study, we assume that in the in suit coronary lesions with FFR>0.85 after PTCA pre-treatment, DCB treatment is not inferior to DES treatment regarding to middle- and long-term functional recovery.
Study Overview
Status
Unknown
Conditions
Intervention / Treatment
Study Type
Interventional
Enrollment (Anticipated)
80
Phase
- Phase 3
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Contact
- Name: Jun Jiang, MD,PhD
- Phone Number: +86-13588706891
- Email: drjayj@hotmail.com
Study Locations
-
-
Zhejiang
-
Hangzhou, Zhejiang, China, 310009
- Recruiting
- Second Affiliated Hospital ZheJiang University School of Medicine
-
Contact:
- Jun Jiang, MD,PhD
- Phone Number: +86-13588706891
- Email: drjayj@hotmail.com
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years and older (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
Clinical Criteria:
- Patients with age >= 18 years old
- Patients with coronary artery disease is confirmed by angiography
- Patients with angina (CCS class II-IV) or documented ischemia evidence with ECG or ECT
- Patients agree to sign the informed consent
Angiographic Criteria:
- In suit coronary lesions
- Reference diameters of target vessels by visual estimation from 2.5 mm to 3.5 mm and < 28 mm in length
- Lesion diameter stenosis >= 70% by visual estimation or >= 50% with objective ischemia evidence (exercise stress testing, ECT or FFR< 0.8)
Exclusion Criteria:
Clinical Criteria:
- Patients with STEMI <= 1 week
- Patients with LVEF < 30%
- Patients with bleeding diathesis or known anticoagulation dysfunction
- Patients with medical history regarding of intracranial tumor, aneurysm, arteriovenous malformation or cerebral apoplexy; stroke or TIA within 6 months; gastrointestinal hemorrhage within 2 months; major surgery within 6 weeks; recent or known platelet < 100,000/mm3 or hemoglobin < 10 g/dL
- Patients with planed selective operation probably leading to stopping using ADP receptor antagonists in advance
- Patients with life expectancy is less than 1 year because of combined comorbidity of other system
Angiographic Criteria:
- Acute thrombotic lesions
- Left main coronary artery lesions
- Severe intima tear lesions
- Coronary artery bypass grafts lesions
- In-stent restenosis
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Drug-coated balloon
Treatment of in suit coronary lesions with drug-coated balloon
|
Treatment of in suit coronary lesions with drug-coated balloon
|
Active Comparator: Drug-eluting stent
Treatment of in suit coronary lesions with drug-eluting stent
|
Treatment of in suit coronary lesions with drug-eluting balloon
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
9-month fractional flow reserve value
Time Frame: 9 months
|
9 months
|
Secondary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Late lumen loss
Time Frame: 9 months
|
9 months
|
Percent restenosis
Time Frame: 9 months
|
9 months
|
Failure rate of target lesions
Time Frame: 9 months
|
9 months
|
Rate of thrombosis in target lesions
Time Frame: 9 months
|
9 months
|
Cumulative MACE rate
Time Frame: 9 months
|
9 months
|
Success rate of the strategy
Time Frame: 9 months
|
9 months
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Collaborators
Investigators
- Study Chair: Jian-an Wang, MD,PhD, Second Affiliated Hospital of Zhejiang University, School of Medicine
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
January 1, 2017
Primary Completion (Anticipated)
September 1, 2018
Study Completion (Anticipated)
September 1, 2018
Study Registration Dates
First Submitted
February 22, 2018
First Submitted That Met QC Criteria
February 26, 2018
First Posted (Actual)
March 2, 2018
Study Record Updates
Last Update Posted (Actual)
March 23, 2018
Last Update Submitted That Met QC Criteria
March 21, 2018
Last Verified
December 1, 2017
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- SAHZJU CT008
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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