Short-term Effects of Tai Chi Chuan Exercise on the Regulation of Lipid and Glucose Metabolisms and Endothelial Function

The Effect of Tai Chi Chuan on the Endothelin, Insulin, Blood Lipid, Blood Sugar, Aldosterone and Hemodynamics in the Elderly Adults

The short term effects of TCC exercise are the significant increase in serum insulin and insulin resistance, and the significant decrease in serum TC, HDL-C, ET-1 and insulin sensitivity in TCC practitioners. TCC might be benefit the health of its practitioners through the regulation of lipid and glucose metabolism and endothelial function.

Study Overview

• Status: Completed
• Conditions: Physiological Effect of TCC on Glucose Metabolism
• Intervention / Treatment: Behavioral: Classical Yang's TCC exercise

Detailed Description

Tai Chi Chuan (TCC) has been shown to be beneficial to the health. However, its effects on lipid and glucose metabolism are not fully understood. This study investigated the short term effect of TCC exercise on lipid and glucose metabolism and endothelial function in TCC practitioners. Twenty-one TCC practitioners and nineteen normal controls were included in this study. The hemodynamics, serum insulin, indices of insulin resistance/sensitivity, serum endothelin-1 (ET-1), blood lipids and aldosterone before and 30 min after a rest or a session of classical Yang's TCC exercise were compared.

• Study Type: Interventional
• Enrollment (Actual): 40
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Taiwan
  • Ilan, Taiwan
    • Wan-An Lu

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Child; Adult; Older Adult
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• TCC practitioners in a TCC training center in Taiwan over 50 years of age
• Healthy subjects without TCC experience over 50 years of age

Exclusion Criteria:

• Subjects who had major cardiopulmonary disease
• Subjects who have diabetes mellitus, renal or liver disease

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Health Services Research
• Allocation: N/A
• Interventional Model: Single Group Assignment
• Masking: None (Open Label)

Number of Arms

1

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: TCC group; Classical Yang's TCC exercise	Behavioral: Classical Yang's TCC exercise

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
change in quantitative insulin sensitivity check index	change in insulin sensitivity due to TCC	before and 30 minutes after the completion of TCC exercise

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
change in serum total cholesterol	change in serum total cholesterol due to TCC	before and 30 minutes after the completion of TCC exercise
change in homeostasis model assessment-estimated insulin resistance	change in insulin resistance by TCC	before and 30 minutes after the completion of TCC exercise

Other Outcome Measures

Outcome Measure	Measure Description	Time Frame
change in serum triglyceride	change in serum level of triglyceride due to TCC	before and 30 minutes after the completion of TCC exercise
change in serum low density lipoprotein	change in serum level of low density lipoprotein due to TCC	before and 30 minutes after the completion of TCC exercise
change in serum high density lipoprotein	change in serum level of high density lipoprotein due to TCC	before and 30 minutes after the completion of TCC exercise
change in serum insulin	change in serum level of insulin due to TCC	before and 30 minutes after the completion of TCC exercise
change in serum endothelin-1	change in serum level of endothelin-1 due to TCC	before and 30 minutes after the completion of TCC exercise
change in serum aldosterone	change in serum level of aldosterone due to TCC	before and 30 minutes after the completion of TCC exercise

Collaborators and Investigators

• Sponsor: Changhua Christian Hospital
• Collaborators: Taipei Veterans General Hospital, Taiwan
• Investigators: Principal Investigator: Cheng-Deng Kuo, MD,PhD, Changhua Christian Hospital

Publications and helpful links

General Publications

• Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985 Jul;28(7):412-9. doi: 10.1007/BF00280883.
• Muniyappa R, Lee S, Chen H, Quon MJ. Current approaches for assessing insulin sensitivity and resistance in vivo: advantages, limitations, and appropriate usage. Am J Physiol Endocrinol Metab. 2008 Jan;294(1):E15-26. doi: 10.1152/ajpendo.00645.2007. Epub 2007 Oct 23.
• Couillard C, Despres JP, Lamarche B, Bergeron J, Gagnon J, Leon AS, Rao DC, Skinner JS, Wilmore JH, Bouchard C. Effects of endurance exercise training on plasma HDL cholesterol levels depend on levels of triglycerides: evidence from men of the Health, Risk Factors, Exercise Training and Genetics (HERITAGE) Family Study. Arterioscler Thromb Vasc Biol. 2001 Jul;21(7):1226-32. doi: 10.1161/hq0701.092137.
• Lu WA, Kuo CD. The effect of Tai Chi Chuan on the autonomic nervous modulation in older persons. Med Sci Sports Exerc. 2003 Dec;35(12):1972-6. doi: 10.1249/01.MSS.0000099242.10669.F7.
• Lu WA, Kuo CD. Three months of Tai Chi Chuan exercise can reduce serum triglyceride and endothelin-1 in the elderly. Complement Ther Clin Pract. 2013 Nov;19(4):204-8. doi: 10.1016/j.ctcp.2013.06.007. Epub 2013 Jul 27.
• Salgado AL, Carvalho Ld, Oliveira AC, Santos VN, Vieira JG, Parise ER. Insulin resistance index (HOMA-IR) in the differentiation of patients with non-alcoholic fatty liver disease and healthy individuals. Arq Gastroenterol. 2010 Apr-Jun;47(2):165-9. doi: 10.1590/s0004-28032010000200009.
• Katz A, Nambi SS, Mather K, Baron AD, Follmann DA, Sullivan G, Quon MJ. Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans. J Clin Endocrinol Metab. 2000 Jul;85(7):2402-10. doi: 10.1210/jcem.85.7.6661.

Study record dates

Study Major Dates

• Study Start (Actual): May 1, 2009
• Primary Completion (Actual): November 30, 2009
• Study Completion (Actual): December 31, 2009

Study Registration Dates

• First Submitted: March 30, 2018
• First Submitted That Met QC Criteria: April 11, 2018
• First Posted (Actual): April 19, 2018

Study Record Updates

• Last Update Posted (Actual): April 19, 2018
• Last Update Submitted That Met QC Criteria: April 11, 2018
• Last Verified: April 1, 2018

More Information

Terms related to this study

• Keywords: insulin resistance; cholesterol; Tai Chi Chuan; endothelin-1
• Other Study ID Numbers: V98E2-014

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO
• IPD Plan Description: Individual participant data (IPD) are available after the manuscript has been accepted for publication

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No