- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03518567
Behavioral Economic Analysis of Demand for Marijuana
February 7, 2024 updated by: Elizabeth Aston, Brown University
This laboratory study will employ a multi-session experimental design to examine the behavioral economic demand for marijuana, by studying effect of marijuana administration (High THC) on demand for marijuana, and marijuana smoking topography.
The study will recruit 100 non-treatment seeking marijuana users who smoke marijuana at least twice weekly.
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Detailed Description
This laboratory study will employ a multi-session experimental design to examine craving for marijuana, the effect of marijuana administration (High THC) on behavioral economic demand for marijuana, and marijuana smoking topography.
The study will recruit 100 non-treatment seeking marijuana users who smoke marijuana at least twice weekly.
The relationship between hypothetical and actual demand for marijuana will be examined.
We will also investigate relationship between demand for marijuana and indices of marijuana smoking topography.
The study will recruit 100 non-treatment seeking marijuana users who smoke marijuana at least twice weekly to obtain a final sample of 85 with complete data (15% of attrition).
Participants will be tested at a baseline session and during two experimental sessions (an ad libitum marijuana smoking session and a marijuana smoking topography session).
This study will confirm the utility of the hypothetical marijuana purchase task as a reliable and valid tool for assessing behavioral economic marijuana demand.
Study Type
Interventional
Enrollment (Actual)
133
Phase
- Phase 2
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
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Rhode Island
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Providence, Rhode Island, United States, 02903
- Brown University
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years to 50 years (Adult)
Accepts Healthy Volunteers
Yes
Description
Inclusion Criteria:
- marijuana use at least 8 times in the past month on average and at least monthly for the past 6 months
- English-speaking
- negative urine toxicology screen for drugs other than marijuana
- non-treatment seeking
- purchase of marijuana at least twice in the past 6 months to confirm familiarity with the construct to be measured
Exclusion Criteria:
- positive pregnancy test
- nursing
- inability to use contraception during the study
- poor physical health
- positive breath alcohol concentration
- diagnosis of a current affective disorder, psychosis, and panic disorder
- self-report of past serious adverse reaction to marijuana
- current psychotropic drug use
- smoking more than 20 tobacco cigarettes per day
- inability to abstain from marijuana for 15 hours
- body mass index outside 18.5-30 kg/m2 range
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Basic Science
- Allocation: N/A
- Interventional Model: Single Group Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: High THC dose (6% THC)
Smoked marijuana cigarettes (High THC dose [6% THC])
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Smoked marijuana cigarettes (High THC dose [6% THC])
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Validity of the Marijuana Purchase Task (MPT)
Time Frame: Duration of the experimental session (i.e., 60 minutes)
|
The Marijuana Purchase Task will be used to collect data on marijuana demand.
Participants indicate how much marijuana they would purchase at varying levels of price (e.g., free - $60).
Indices of marijuana demand are derived from the task and used to determine the relative value of marijuana for each participant.
Hits purchased on the MPT will correspond with actual number of hits purchased and smoked in the laboratory.
Primary outcome is percentage of participants who purchased and smoked exactly what they said they would.
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Duration of the experimental session (i.e., 60 minutes)
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Change in Marijuana Craving Questionnaire (MCQ)
Time Frame: The MCQ will be administered pre- and post- marijuana smoking during the experimental session, up to 6 hours
|
Subjective marijuana craving was assessed via a 10-item Marijuana Craving Questionnaire.
Participants were asked to respond to items according to how they were thinking or feeling "right now," and MCQ items were rated on a 1 = "strongly disagree" to 7 = "strongly agree" scale, with higher scores indicating greater subjective marijuana craving, and summed to yield a total craving score.
Total craving score was used in analyses.
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The MCQ will be administered pre- and post- marijuana smoking during the experimental session, up to 6 hours
|
Marijuana Smoking Topography
Time Frame: Marijuana smoking topography indices will be collected during the 1-hour ad libitum marijuana smoking topography experimental session.
|
Indices of Marijuana Smoking Topography will be obtained during the experimental session.
Participants will smoke marijuana through a smoking topography device.
The outcome measure is number of puffs.
|
Marijuana smoking topography indices will be collected during the 1-hour ad libitum marijuana smoking topography experimental session.
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Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Investigators
- Principal Investigator: Elizabeth Aston, PhD, Brown University
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
October 15, 2018
Primary Completion (Actual)
May 24, 2021
Study Completion (Actual)
May 24, 2021
Study Registration Dates
First Submitted
April 9, 2018
First Submitted That Met QC Criteria
May 3, 2018
First Posted (Actual)
May 8, 2018
Study Record Updates
Last Update Posted (Actual)
February 12, 2024
Last Update Submitted That Met QC Criteria
February 7, 2024
Last Verified
February 1, 2024
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- #1502001185
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Yes
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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