Body Weight-Based Interval Training in Sedentary Overweight and Obese Adults

The Effect of Interval Training Using Body Weight on Body Composition in Sedentary Overweight and Obese Adults

Body-weight based interval training (IT) performed 3 times per week will lead to reductions in abdominal adiposity and reduce overall body fat percentage in overweight and obese sedentary adults more effectively than moderate intensity continuous training (MICT). Body-weight interval training will improve exercise capacity (peak VO2) in overweight/obese adults.

Study Overview

• Status: Completed
• Conditions: Physical Activity; Body Weight Changes; Overweight and Obesity
• Intervention / Treatment: Behavioral: Standard of Care; Behavioral: Interval Training

Detailed Description

Participants will be randomly assigned to one of the two home-based exercise groups.

The MICT group is the standard care group and will be instructed to walk for 30 minutes, 5 days per week at a moderate intensity. The goal is to accumulate 150 minutes of continuous aerobic exercise each week. Participants will be instructed on the use of the Rating of Perceived Exertion (RPE) scale during baseline testing and will be instructed to reach an RPE of 12-16. A heart rate monitor will be worn to monitor exercise intensity. Heart rate should reach ~70% of maximal heart rate.

The IT group will perform 5 body-weight exercises in three progressive phases. During the first 2 weeks the circuit will be completed twice, 30 second intervals, 90 seconds of rest. The exercises will be performed on 3 days of the week with at least one day of rest between exercise days (ideally Monday, Wednesday, Friday). The number of repetitions will increase to a maximum of 4 while the interval and rest periods increase to a maximum of 45 seconds each. The total time spent performing intervals by week 8 will be 15 minutes. A 2 minute warm up and 3 minute cool down will be performed, such as jumping jacks or simply walking. A heart rate monitor will be used to measure exercise intensity. Heart rate should reach approximately 90% of heart rate max during the intervals. Participants will be instructed on the use of the Rating of Perceived Exertion scale during baseline testing and will be instructed to reach an RPE of ≥17 during the high intensity intervals.

• Study Type: Interventional
• Enrollment (Actual): 22
• Phase: Not Applicable

Contacts and Locations

Study Locations

• United States
  • Minnesota
    • Rochester, Minnesota, United States, 55905
      • Mayo Clinic in Rochester

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 65 years (Adult, Older Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• Adults 18-65 years of age
• Willing and able to provide informed consent
• Sedentary, overweight and obese adults (<90 minutes of moderate intensity exercise)
• BMI 25≤35
• Able to safely begin an exercise program
• Have a smartphone, and willing and able to download and use the Fitbit app

Exclusion Criteria:

• Unable to provide informed consent.
• Known cardiovascular disease, or uncontrolled hypertension,
• Diagnosed type 1 or 2 diabetes
• Women who are pregnant or plan to become pregnant in the next 3-4 months
• Orthopedic injury/limitation or any other contraindications to exercise.
• Medications that cause weight gain (steroids, HIV-related medications, etc.), or glucose lowering medications

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Other
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: None (Open Label)

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Active Comparator: Standard Walking; This arm is prescribed standard of care exercise prescription; 30 minutes of moderate intensity walking, 5 days/week.	Behavioral: Standard of Care; Walking prescribed to meet current exercise guidelines; 150 minutes per week.
Experimental: Interval Training; This arm is prescribed body-weight based interval training 3 days per week with progressive increase in exercise intervals and sets.	Behavioral: Interval Training; Interval training is prescribed 3 days per week using 5 body weight exercises in a progressive fashion.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Change in Body fat percent	DEXA derived body fat %	12 weeks

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Change in Weight	Weight in kilograms	12 weeks
Change in peak VO2	Peak VO2 in ml/kg/min	12 weeks
Visceral adipose tissue area	cm^2	12 weeks
Thigh adipose tissue area	cm^2	12 weeks

Collaborators and Investigators

• Sponsor: Mayo Clinic
• Investigators: Principal Investigator: Amanda R Bonikowske, Mayo Clinic

Publications and helpful links

Helpful Links

• Mayo Clinic Clinical Trials

Study record dates

Study Major Dates

• Study Start (Actual): November 6, 2018
• Primary Completion (Actual): January 8, 2021
• Study Completion (Actual): January 8, 2021

Study Registration Dates

• First Submitted: April 30, 2018
• First Submitted That Met QC Criteria: May 11, 2018
• First Posted (Actual): May 14, 2018

Study Record Updates

• Last Update Posted (Actual): January 11, 2021
• Last Update Submitted That Met QC Criteria: January 8, 2021
• Last Verified: January 1, 2021

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Overweight; Body Weight; Body Weight Changes
• Other Study ID Numbers: 17-010163

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No