- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03632746
Verifying the Specificity of a New Method in Predicting Lymph Node Metastasis in Early Gastric Cancer Patients
August 13, 2018 updated by: Zhaode Bu, MD
Verifying the Specificity of the Method Combining Nomogram and Sentinel Lymph Node in Predicting Lymph Node Metastasis in Early Gastric Cancer Patients: a Prospective, Single Arm, Observational Study
Early gastric cancer is defined as gastric cancer that only invades mucosal or submucosal layer.
The 5-year survival rate of gastric cancer can exceed 90% due to appropriate treatment.
The most important consideration is whether there is lymph node metastasis.
Preoperative examination including gastroscopy, endoscopic ultrasonography (EUS) and CT are not accurate enough to predict lymph node metastasis in early gastric cancer.
In a retrospective study, we created a nomogram to predict lymph node metastasis in early gastric cancer.
In prospective validation, the sensitivity and specificity of the nomogram was 75% and 91%, respectively.
Sentinel lymph node is a promising concept in early gastric cancer.
Using carbon nanoparticles as tracer, the sensitivity and specificity of sentinel lymph node predicting lymph node metastasis in early gastric cancer were 90% and 100%.
Based on these results, we proposed a new method that combines the Nomogram and sentinel lymph node to predict lymph node metastasis in early gastric cancer.
First, the probability of lymph node metastasis of early gastric cancer patients is calculated by the Nomogram.
Those with low incidence of lymph node metastasis continue to the sentinel lymph node procedure.
A patient will be considered non lymph node metastasis if his/her frozen pathology of the sentinel lymph nodes is negative during the surgery.
Then the standard radical gastrectomy is performed with lymphadenectomy.
By comparing postoperative pathology and sentinel lymph node frozen pathology, the specificity of Nomogram combining sentinel lymph node predicting lymph node metastasis in early gastric patients is calculated.
The primary endpoint of this research is that the specificity of the above-mentioned method is over 95%.
Study Overview
Status
Unknown
Conditions
Study Type
Observational
Enrollment (Anticipated)
80
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
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Beijing
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Beijing, Beijing, China, 100000
- Beijing Cancer Hospital
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years to 80 years (Adult, Older Adult)
Accepts Healthy Volunteers
N/A
Genders Eligible for Study
All
Sampling Method
Non-Probability Sample
Study Population
Early gastric cancer patients with clinical stage T1N0M0
Description
Inclusion Criteria:
- diagnosed as gastric cancer by gastroscopy
- pathologically confirmed as adenocarcinoma
- ages between 18 and 80
- gastroscopy, abdominal enhanced CT and EUS completed
- clinical stage T1N0M0
- the score of the Nomogram less than 110
- potential resectable gastric cancer
- signed informed consent
Exclusion Criteria:
- absolute indication for endoscopic submucosal dissection (ESD)
- tumor located in esophagogastric junction (EGJ)
- accepted adjuvant therap
- pregnant or breast feeding
- history of upper abdominal surgery (laparoscopic cholecystectomy not included)
- history of gastric surgery
- emergency surgery such as perforation or obstruction
- other contraindication such as dysfunction of heart, lung, kidney
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
The specificity of the Nomogram combining sentinel lymph node in predicting lymph node metastasis in early gastric cancer patients
Time Frame: 10 days after surgery when postoperative pathology result comes out
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10 days after surgery when postoperative pathology result comes out
|
Secondary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
The sensitivity of the Nomogram combining sentinel lymph node in predicting lymph node metastasis in early gastric cancer patients
Time Frame: 10 days after surgery when postoperative pathology result comes out
|
10 days after surgery when postoperative pathology result comes out
|
The sensitivity of the Nomogram alone in predicting lymph node metastasis in early gastric cancer patients
Time Frame: 10 days after surgery when postoperative pathology result comes out
|
10 days after surgery when postoperative pathology result comes out
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Investigators
- Principal Investigator: Zhaode Bu, M.D., Peking University Cancer Hospital & Institute
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Anticipated)
September 1, 2018
Primary Completion (Anticipated)
December 31, 2020
Study Completion (Anticipated)
December 31, 2020
Study Registration Dates
First Submitted
August 13, 2018
First Submitted That Met QC Criteria
August 13, 2018
First Posted (Actual)
August 15, 2018
Study Record Updates
Last Update Posted (Actual)
August 15, 2018
Last Update Submitted That Met QC Criteria
August 13, 2018
Last Verified
August 1, 2018
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- Pre gastric preserving study
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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