- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03815305
Effect of Centella Asiatica on Xerotic Skin in Diabetes Mellitus Type 2
January 20, 2019 updated by: Dr. Lili Legiawati, SpKK(K), Indonesia University
Effect of Centella Asiatica on Xerotic Skin in Diabetes Mellitus Type 2: a Study on N(6)-Carboxymethyl-lysine, Interleukin 1-α, Dan Superoxide Dismutase in Stratum Corneum
The objective of this study is to evaluate the effect of Centella asiatica on hydration status of lower leg skin of DM type 2 patients by measuring SRRC and Skin Capacitance in correlation with AGEs CML, inflammation marker IL-1α, and oxidative stress SOD in stratum corneum.
Study Overview
Status
Unknown
Conditions
Intervention / Treatment
Detailed Description
This ia a double blind randomized clinical trial on patients diagnosed with DM type 2 with dry skin to assess the effect of Centella asiatica (CA) on dry skin in corellation with AGEs CML, inflammation marker IL-1α, and oxidative stress SOD in stratum corneum after four weeks of treatment.
Subjects are divided into three groups of treatment.
The first group treated with oral CA and topical CA, second group treated with oral placebo and topical CA, and the last group treated with oral and topical placebo.
The total subjects in each treatment groups are 53 subjects.
The recruited subjects will be randomized to receive three different treatments, consist of 1.
First group (A) will receive combination of oral CA at 2x1100 mg dose and 1% topical CA ointment.
2. Second group (B) will receive oral placebo and topical CA 1% ointment 3. Third group (C) will receive oral placebo and petroleum jelly as topical placebo The recruited subjects will still receive the prescribed treatment for DM type 2. The treatment for dry skin will be administered for 28 days.
Randomization done by our supervisor using computer program (RandlistR) by assigning code number for each subjects.
The procedures of treatment administration are explained below: 1.
Every subject will receive 56 capsules and 10 gram of ointment to be used in 2 weeks period.
Subjects will also receive explanation on how to take the drugs 2. Oral drug are taken 2 capsules (@ 550 mg) b.i.d over 12 hours.
3. The ointment is applied two times a day 15 minutes after bath time.
4. The application have to be distributed evenly on a specific 7 x 20 cms area on lower leg.
All patients will be given plastic cover to determine the area. 5.
The estimation of ointment applied on every leg is as much as ½ FTU or about 0,25 gram.
6.
After 2 week period ended, subject will be given the same treatment at follow-up visit.
Study Type
Interventional
Enrollment (Actual)
159
Phase
- Phase 4
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
Jakarta
-
Jakarta Pusat, Jakarta, Indonesia, 10430
- Universitas Indonesia
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
No older than 60 years (Child, Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
- Diagnosed with Diabetes Mellitus Type 2
- <60 years old by the end of the study
- suffered from dry skin on lower leg skin area, (minimum score= 3, measured using SRRC)
- agree to not use any skin care product orally or topically on lower leg skin and any other drugs (unless its part of diabetes mellitus management)
- normal ankle brachial index value ranged from 0.91-1.3
Exclusion Criteria:
- the presence of diabetic ulcer on one of patient's foot
- the presence of infection or dermatitis on the experimented foot
- the presence of severe inflammation on the experimented skin (redness score >2 or/and fissure score >2 measured by SRRC or/and total SRRC score ranged from12-16)
- estimated glomerular filtration rate value (eGFR) < 45
- impaired liver function (increased by 2x from upper limit reference for AST/ALT)
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Triple
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Active Comparator: Topical CA and Placebo Oral Drug
Patient given 10gr 1% CA ointment and 56 pcs of placebo drug
|
1% centella asiatica ointment
Other Names:
|
Placebo Comparator: Petroleum Jelly and placebo oral drug
Patient given 10gr petroleum jelly 100% topical ointment and 56 pcs of placebo drug
|
vaseline album
Other Names:
|
Experimental: Centella asiatica extract and Topical CA
Patient given 10gr 1% CA ointment and 56 pcs of drug containing CA
|
centlla asiatica oral drug at 1100 mg dose
Other Names:
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Change in Skin Capacitance
Time Frame: 1 month (evaluated every 2 weeks)
|
SCap measured in (AU)
|
1 month (evaluated every 2 weeks)
|
Change in SOD
Time Frame: 1 month (evaluated every 2 weeks)
|
Superoxide Dismutase (compared to total protein)
|
1 month (evaluated every 2 weeks)
|
Change in IL-1α
Time Frame: 1 month (evaluated every 2 weeks)
|
Interleukin-1α (compared to total protein)
|
1 month (evaluated every 2 weeks)
|
Change in AGEs CML
Time Frame: 1 month (evaluated every 2 week)
|
Advanced Glycation End Product, N-(Carboxymethyl)lysine (compared to total protein)
|
1 month (evaluated every 2 week)
|
Change in SRRC
Time Frame: 1 month (evaluated every 2 week)
|
Specified symptom sum score.
Measuring dry skin using four variables (scale, roughness, redness, and cracking) in score ranged from 1 to 4 for each variable.
The highest the value marks the driest skin
|
1 month (evaluated every 2 week)
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Investigators
- Study Chair: Suhendro Suhendro, Doctor, Indonesia University
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
July 30, 2018
Primary Completion (Actual)
January 12, 2019
Study Completion (Anticipated)
June 30, 2019
Study Registration Dates
First Submitted
January 18, 2019
First Submitted That Met QC Criteria
January 20, 2019
First Posted (Actual)
January 24, 2019
Study Record Updates
Last Update Posted (Actual)
January 24, 2019
Last Update Submitted That Met QC Criteria
January 20, 2019
Last Verified
January 1, 2019
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 441/UN2.F1/ETIK/2018/
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Diabetes Mellitus, Type 2
-
SanofiCompletedType 1 Diabetes Mellitus-Type 2 Diabetes MellitusHungary, Russian Federation, Germany, Poland, Japan, United States, Finland
-
Mannkind CorporationTerminatedType 2 Diabetes Mellitus | Type 1 Diabetes MellitusUnited States
-
RWTH Aachen UniversityBoehringer IngelheimCompletedDiabetes Mellitus Type 2 (T2DM)Germany
-
Griffin HospitalCalifornia Walnut CommissionCompletedDIABETES MELLITUS TYPE 2United States
-
University Hospital Inselspital, BerneCompletedType 2 Diabetes MellitusSwitzerland
-
India Diabetes Research Foundation & Dr. A. Ramachandran...CompletedTYpe 2 Diabetes MellitusIndia
-
Scripps Whittier Diabetes InstituteSan Diego State UniversityCompletedType 2 Diabetes Mellitus (T2DM)United States
-
AstraZenecaRecruiting
-
Daewoong Pharmaceutical Co. LTD.Not yet recruitingT2DM (Type 2 Diabetes Mellitus)
-
Zhongda HospitalRecruitingType 2 Diabetes Mellitus (T2DM)China
Clinical Trials on Topical CA
-
Luzerner KantonsspitalRecruiting
-
National University of SingaporeAgency for Science, Technology and Research; AMILI Pte. Ltd.Recruiting
-
Curis, Inc.CompletedAdvanced Solid Tumors or LymphomasUnited States, Spain, Korea, Republic of, United Kingdom
-
Ensho Health Intelligent Systems Inc.Enrolling by invitationTransthyretin Amyloid Cardiomyopathy ("ATTR-CM")Canada
-
University of LeipzigCuris, Inc.RecruitingMyelodysplastic Syndromes | AnemiaGermany
-
Idego srlCompletedSelf Efficacy | MotivationItaly
-
Concentric AnalgesicsCompletedHallux Valgus DeformityUnited States
-
Western Sydney Local Health DistrictNational Heart Foundation, Australia; University of SydneyNot yet recruitingArrhythmias, Cardiac | Cardiomyopathies | Ventricular Tachycardia | Ventricular Arrythmia
-
National and Kapodistrian University of AthensAghia Sophia Children's Hospital of Athens; Institute of Educational Policy; Ministry...CompletedStress | Health Promotion | AdolescenceGreece