Comparison of Picosecond Pulsed Nd:YAG Laser and Fractional Laser for the Treatment of Acne Scars

August 24, 2026 updated by: Dongtan Sacred Heart Hospital
This study compares the application of a picosecond 1064-nm laser with a diffractive lens array with nonablative fractional laser for the treatment of acne scarring.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

This trial is a 17-week, prospective, randomized split-face study that compares the results between two facial sides either receiving the picosecond 1064-nm laser or nonablative fractional laser treatment for atrophic acne scar.

Study Type

Interventional

Enrollment (Actual)

25

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • South Korea
    • Gyeonggi-do
      • Hwaseong-si, Gyeonggi-do, South Korea, 18450
        • Dongtan Sacred Heart Hospital, Hallym Universtiy College of Medicine

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

19 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

Yes

Description

Inclusion Criteria:

  • Subjects with facial atrophic acne scars
  • Subjects who observe the schedules and protocols of the clinical trial
  • Subjects who give informed consent to participate in the clinical trial

Exclusion Criteria:

  • Subjects who have active acne under treatment
  • Subjects who had received any other treatments for acne scarring for 6 months prior to the first treatment
  • Subjects who underwent other treatments including chemical, mechanical or laser resurfacing during the study period
  • Subjects who have current acute illness
  • Subjects who are considered inappropriate for the clinical trial under the judgement of investigators

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Picosecond laser
Intervention: four consecutive sessions of 1,064-nm picosecond laser at 3-week intervals
Procedure: Laser therapy
4 consecutive sessions of laser therapy
Active Comparator: Fractional laser
Intervention: four consecutive sessions of nonablative fractional laser at 3-week intervals
Procedure: Laser therapy
4 consecutive sessions of laser therapy

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Changes in the mean of the ECCA grading scale
Time Frame: Week 17
The ECCA (échelle d'évaluation clinique des cicatrices d'acné) grading scale: minimum score 0; maximum score 270; higher values represent a worse outcome.
Week 17

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Dongtan Sacred Heart Hospital

Investigators

  • Principal Investigator: Gyeong-Hun Park, MD, PhD, Dongtan Sacred Heart Hospital, Hallym University College of Medicine

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

May 1, 2019

Primary Completion (Actual)

April 22, 2020

Study Completion (Actual)

April 22, 2020

Study Registration Dates

First Submitted

February 20, 2019

First Submitted That Met QC Criteria

February 21, 2019

First Posted (Actual)

February 22, 2019

Study Record Updates

Last Update Posted (Actual)

August 26, 2026

Last Update Submitted That Met QC Criteria

August 24, 2026

Last Verified

August 1, 2026

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 2019_02_004

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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