Acute Effect of Isometric Exercise on Blood Pressure in Hypertensive Patients

Acute Effect of Isometric Physical Exercise on Blood Pressure in Patients With Controlled Hypertension

International recommendations advocate dynamic or isometric strength training as an adjunct to aerobic exercise. Due to a lack of consensus, this research addresses the acute effects of isometric exercises by handgrip or lower limb isometry as a hypotensive strategy in hypertensive adults.

Study Overview

• Status: Recruiting
• Conditions: Arterial Hypertension
• Intervention / Treatment: Other: isometric handgrip exercise; Other: isometric of the lower limbs

Detailed Description

This study is characterized as a randomized, controlled and blinded clinical trial for the evaluators and carried out integrally in the Laboratory of Clinical Investigation (LIC) of the Cardiology Institute of Rio Grande do Sul / University Foundation of Cardiology (ICFUC). The project follows all recommendations proposed by the CONSORT Statement.

The study will consist of individuals of both genders, aged between 40 and 70 years who have blood pressure above 120mmhg by 80mhg. The participants, after signing the informed consent, answered a questionnaire that will evaluate the habitual level of physical activity and will be submitted to isometric exercises of palmar grip or quadriceps muscle. Pre- and post-exercise blood pressure will be monitored through the ambulatory blood pressure monitoring (ABPM) method.

• Study Type: Interventional
• Enrollment (Anticipated): 80
• Phase: Not Applicable

Contacts and Locations

• Study Contact: Name: Alexandre Lehnen, PHD; Phone Number: +555199768092; Email: amlehnen@gmail.com
• Study Contact Backup: Name: Patrícia Caetano, graduate; Phone Number: +5551992039364; Email: fisio.patriciacaetano@gmail.com

Study Locations

• Brazil
  • Rio Grande Do Sul
    • Porto Alegre, Rio Grande Do Sul, Brazil, 90040-371
      • Recruiting
      • Instituto de Cardiologia/ fundação Universitária de Cardiologia
      • Contact: Patrícia C de Oliveira; Phone Number: (51)992039364; Email: fisio.patriciacaetano@gmail.com
      • Contact: Instituto de Cardiologia; Phone Number: 4124 5132303600; Email: ppgfuc@gmail.com

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 36 years to 66 years (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• Controlled hypertensive patients (use of medication) sedentary or physically inactive

Exclusion Criteria:

• Pregnant women;
• Unstable angina;
• Class II, III or IV heart failure;
• Recent cardiovascular event (last 3 months);
• Chronic renal insufficiency;
• Diabetes;
• History of malignant diseases with life expectancy <2 years;
• Or Orthopedic limitations or any physical or mental limitation that impedes the performance of physical exercises.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Single

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: isometric handgrip exercise; Isometric session with handgrip: 4 sets of 2 minutes of contractions sustained at 30% of CVM, for each arm. The time between sets and between arms will be 1 minute rest.	Other: isometric handgrip exercise; Isometric session with handgrip: 4 sets of 2 minutes of contractions sustained at 30% of CVM, for each arm. The time between sets and between arms will be 1 minute rest.
Experimental: isometric of lower limbs; Isometric session for lower limbs: 4 series with 2 minutes of contractions sustained at 30% of 1RM. The rest interval will be 1 minute.	Other: isometric of the lower limbs; Isometric session for lower limbs: 4 sets with 2 minutes of contractions sustained at 30% of 1RM. The rest interval will be 1 minute rest.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
blood pressure	Blood pressure will be evaluated by Ambulatory Blood Pressure Monitoring (ABPM) over 24h. For that, a Dyna-Map® branded instrument will be used, which will measure blood pressure on rest condition and another measure after the exercise session (totaling 48 horas), in all participants of the two study groups.	48 hours

Collaborators and Investigators

• Sponsor: Instituto de Cardiologia do Rio Grande do Sul
• Investigators: Principal Investigator: Patricia Caetano, graduate, Instituto de Cardiologia/ fundação Universitária de Cardiologia

Study record dates

Study Major Dates

• Study Start (Actual): December 9, 2019
• Primary Completion (Anticipated): March 18, 2022
• Study Completion (Anticipated): March 18, 2022

Study Registration Dates

• First Submitted: April 15, 2019
• First Submitted That Met QC Criteria: June 7, 2019
• First Posted (Actual): June 12, 2019

Study Record Updates

• Last Update Posted (Actual): July 28, 2021
• Last Update Submitted That Met QC Criteria: July 27, 2021
• Last Verified: July 1, 2021

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Cardiovascular Diseases; Vascular Diseases; Hypertension
• Other Study ID Numbers: PCaetano

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: No

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No