Cardiovascular Response to Isometric BFR Exercise

June 11, 2025 updated by: University of Texas at Austin

Blood Pressure Responses to Isometric Blood Flow Restriction Exercise

The goal of this interventional study is to evaluate the acute impact of isometric blood flow restriction (BFR) exercise on blood pressure and other cardiovascular functions in healthy young adult volunteers. The main question it aims to answer is:

The investigators hypothesize that isometric BFR exercise with a wide-rigid cuff would lead to greater blood pressure and other cardiovascular responses and that these cardiovascular responses would be greater under isometric BFR exercise with narrow-elastic bands compared with the control condition (no cuff).

Participants will perform isometric exercises in 3 laboratory visits with different exercise conditions) no cuff control 2) BFR with wide-rigid cuff 3) BFR with narrow-elastic band.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

21

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • United States
    • Texas
      • Austin, Texas, United States, 78712-1415
        • Cardiovascular Aging Research Laboratory

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult

Accepts Healthy Volunteers

Yes

Description

Inclusion Criteria:

- Apparently healthy young adults aged between 18 - 40 years old and signed the informed consent.

Exclusion Criteria:

  • Abnormal clotting times
  • Acid-base imbalance/acidosis
  • Arterial calcification
  • Atherosclerotic vessels
  • Cardiopulmonary conditions
  • Diabetes
  • Dialysis/central venous access
  • General/local infection
  • High intracranial pressure
  • Hip, pelvis, or femur fracture
  • History of venous thromboembolism
  • Hypertension
  • Immobility for greater than 48 hours in the past month
  • Immobilizing cast
  • Implanted medical device
  • Lymphectomies
  • Obesity
  • Open fracture
  • Open or unhealed soft tissue injuries
  • Paralysis
  • Peripheral vascular disease
  • Pregnancy/postpartum
  • Prior revascularization
  • Renal compromise
  • Severe crush injuries
  • Sickle cell trait/anemia
  • Skin grafts
  • Stroke
  • Temporary nerve damage
  • Thrombophilia
  • Tumor/cancer
  • Varicose veins
  • Vascular grafting

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Basic Science
  • Allocation: Randomized
  • Interventional Model: Crossover Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Active Comparator: Isometric exercise without BFR cuff (control)
Behavioral: Isometric handgrip exercise
The participants will perform isometric handgrip exercises without blood flow restriction.
Experimental: Isometric exercise with narrow-elastic BFR band
Behavioral: Isometric handgrip exercise with a narrow-elastic band
The participants will perform isometric handgrip exercises with blood flow restriction using a narrow-elastic band.
Experimental: Isometric exercise with wide-rigid BFR cuff
Behavioral: Isometric handgrip exercise with a wide-rigid cuff
The participants will perform isometric handgrip exercises with blood flow restriction using a wide-rigid cuff.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Systolic blood pressure and diastolic blood pressure
Time Frame: 20 minutes
Beat-by-beat (both systolic and diastolic blood pressure) blood pressure before, during, and after exercise
20 minutes
Brachial artery diameter evaluated by an ultrasound machine
Time Frame: Before and 20 minutes after exercise
Brachial artery diameter will be measured by an ultrasound machine to calculate flow-mediated dilation (FMD)
Before and 20 minutes after exercise
Heart rate
Time Frame: 20 minutes
Monitor heart rate continuously before, during, and after exercise
20 minutes

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University of Texas at Austin

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

December 2, 2024

Primary Completion (Actual)

May 30, 2025

Study Completion (Actual)

May 30, 2025

Study Registration Dates

First Submitted

July 18, 2024

First Submitted That Met QC Criteria

July 25, 2024

First Posted (Actual)

July 31, 2024

Study Record Updates

Last Update Posted (Actual)

June 12, 2025

Last Update Submitted That Met QC Criteria

June 11, 2025

Last Verified

June 1, 2025

More Information

Terms related to this study

Other Study ID Numbers

  • STUDY00006378

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

UNDECIDED

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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