Adrenaline During Resuscitation From Pulseless Electrical Activity

This is a prospective observational study at St. Olavs hospital in Norway. Data are gathered from defibrillators that have been in use during resuscitation from cardiac arrest. Aim is to investigate the changes in electrocardiograms (ECG) during resuscitation from pulseless electrical activity (PEA), which is a type of cardiac arrest. ECG changes may be useful as a prognostic marker during resuscitation from PEA. In addition the researchers will describe the effect of adrenaline and chest compressions on clinical state transitions during resuscitation from pulseless electrical activity. Clinical state transitions are changes between different types of cardiac arrest. This study is expected to increase our understanding of the dynamics during treatment of cardiac arrest.

Study Overview

• Status: Completed
• Conditions: Heart Arrest

• Study Type: Observational
• Enrollment (Actual): 280

Contacts and Locations

Study Locations

• Norway
  • Trondheim, Norway
    • St Olavs hospital
• United States
  • Pennsylvania
    • Philadelphia, Pennsylvania, United States, 19104
      • Hospital Of the University of Pennsylvania

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No

• Sampling Method: Non-Probability Sample

Study Population

The population will consist of patients suffering cardiac arrest while being hospitalized at St. Olavs hospital.

Description

Inclusion Criteria: Cardiac arrest among hospitalized patients presenting with PEA as the primary rhythm.

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort
Patients with primary PEA.; Patients at St. Olavs hospital who suffer cardiac arrest and pulseless electrical activity (PEA) as primary rhythm during 2018-2021. 120 episodes from St. Olavs hospital were collected previously (2010-2013). In addition 200 cases will be available from the hospital of The University of Pennsylvania, Philadelphia, USA.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
QRS frequency	Measurement of RR intervals in milliseconds.	Every 3 minutes from start till end of cardiopulmonary resuscitation
QRS width	Measurement of the width of QRS complexes in milliseconds	Every 3 minutes from start till end of cardiopulmonary resuscitation
Changes of clinical states	changes of clinical states (for example from Pulseless electrical activity to Ventricular fibrillation) during treatment of cardiac arrest.	Every 3 minutes from start till end of cardiopulmonary resuscitation

Collaborators and Investigators

• Sponsor: St. Olavs Hospital
• Collaborators: University of Pennsylvania; Norwegian University of Science and Technology
• Investigators: Study Director: Eirik Skogvoll, md prof, St. Olavs Hospital

Study record dates

Study Major Dates

• Study Start (Actual): March 20, 2019
• Primary Completion (Actual): January 1, 2023
• Study Completion (Actual): May 15, 2023

Study Registration Dates

• First Submitted: October 18, 2019
• First Submitted That Met QC Criteria: October 31, 2019
• First Posted (Actual): November 4, 2019

Study Record Updates

• Last Update Posted (Actual): September 5, 2023
• Last Update Submitted That Met QC Criteria: September 1, 2023
• Last Verified: September 1, 2023

More Information

Terms related to this study

• Keywords: Epinephrine; Pulseless electrical activity
• Additional Relevant MeSH Terms: Heart Diseases; Cardiovascular Diseases; Heart Arrest
• Other Study ID Numbers: 2019/785

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No