- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04254484
SIESTA (Sleep of Inpatients: Empower Staff to Act) for Acute Stroke Rehabilitation
Study Overview
Status
Conditions
Intervention / Treatment
Study Type
Enrollment (Estimated)
Phase
- Not Applicable
Contacts and Locations
Study Locations
-
-
Illinois
-
Chicago, Illinois, United States, 60611
- Shirley Ryan AbilityLab
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Description
Inclusion Criteria
- Individuals diagnosed with stroke admitted to the Shirley Ryan AbilityLab (inpatient)
- Age 18 or older
- Able and willing to give written consent and comply with study procedures . Medical clearance from physician
Exclusion Criteria
- Serious cardiac conditions or neurological degenerative pathologies as co-morbidities (such as multiple sclerosis, Alzheimer's disease, Parkinson's disease, etc.)
- Pregnant or nursing
- Skin allergies or irritation; open wounds
- Utilizing a powered, implanted cardiac device for monitoring or supporting heart function (i.e. pacemaker, defibrillator, or LVAD)
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Health Services Research
- Allocation: Non-Randomized
- Interventional Model: Parallel Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: SIESTA Rehab
Stroke floor on which nurses will be receiving training (SIESTA Rehab Education) on how to minimize nighttime disruptions and batching overnight tasks to preserve sleep for patients hospitalized on that floor. Stroke patients admitted to the SIESTA Rehab Unit will be screening for sleep disordered breathing using ApneaLink. Patients hospitalized on this unit will be approached for consent to wear sensors and actigraphy watches during the hospital stay and after discharge. |
Staff nurses will be trained on how to improve sleep in stroke patients in the acute rehabilitation setting.
Stroke patients on the SIESTA Rehab unit will be screened for sleep disordered breathing using ApneaLink monitors.
Results will be interpreted by a sleep specialist who will then advise the clinical team at SRALab.
|
No Intervention: Control Unit
Patients on this unit will receive usual care for stroke patients as outlined by SRALab. including routine nursing care without any intervention to promote sleep like SIESTA and routing sleep disorders screenings based on clinician judgement. Patients hospitalized on this unit will also be approached for consent to wear sensors and actigraphy watches during the hospital stay and after discharge. |
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Quality Indicator (QI) Score
Time Frame: Up to 3 months
|
The QI score is a measure used in the inpatient setting at the Shirley Ryan AbilityLab that has replaced the Functional Independence Measure (FIM).
The score can be obtained in all patients, regardless of stroke type or deficit.
The QI evaluates level of disability, and how much assistance is needed for a subject to perform activities of daily living.
Each item is scored ranging from total assistance to total independence.
Items include eating, grooming, bathing, dressing, toiling, bladder/bowel management, transfers, locomotion, stairs, comprehension, etc.
|
Up to 3 months
|
Karolinska Sleep Diary
Time Frame: Daily during inpatient stay starting with study admission. Average length of stay is 17 days.
|
This questionnaire calculates the sleep quality index (SQI) using four items: slept throughout, sleep restless, ease falling asleep, and premature awakenings.
A higher SQI indicates better sleep quality.
Additionally, three items (ease awakening, refreshed, sufficient sleep) yield an awake score with lower scores indicating better sleep.
Items have 5-point verbal anchors, and response alternatives vary with each question.
It has been correlated with measures from polysomnography to measure sleep quality the night prior to administration.
|
Daily during inpatient stay starting with study admission. Average length of stay is 17 days.
|
Modified Potential Disruptions of Hospital Sleep Questionnaire (PDHSQ)
Time Frame: Daily during inpatient stay starting with study admission. Average length of stay is 17 days.
|
This subjective questionnaire asks inpatients how specific items disrupted their sleep the prior night from 1 (not disruptive) to 5 (extremely disruptive).
Select items correlate with in-hospital actigraphy, and specific items address rehabilitation.
|
Daily during inpatient stay starting with study admission. Average length of stay is 17 days.
|
Change in total sleep time as measured by Actigraphy
Time Frame: Overnight for first and last three nights of their stay. Average length of stay is 17 days.
|
Small multi-modality research-grade, wireless, and wearable sensors (Philips Actiwatch and Actigraph wGT3X-BT) are used to calculate total sleep time.
|
Overnight for first and last three nights of their stay. Average length of stay is 17 days.
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Apnea Hypopnea Index (AHI)
Time Frame: One night around admission to the study.
|
obtained from the ApneaLink™ devices, which are simple, cost-effective portable devices for diagnosing sleep-disordered breathing.
It automatically analyzes and derives an AHI, flow limitation, snoring and oxygen desaturation index.
The automatic analysis will be reviewed by an expert sleep specialist to ensure correct interpretation.
The AHI is calculated based on number of events of apnea or blood O2 desaturation per hour, with <5 being normal and >30 being severe
|
One night around admission to the study.
|
Electronic Chart Audit
Time Frame: Continuously during inpatient stay starting with study admission. Average length of stay is 17 days.
|
We will obtain objective baseline data on orders of nighttime vitals, nocturnal medications that disrupt sleep (heparin q8, nighttime medications, bathing, etc.).
|
Continuously during inpatient stay starting with study admission. Average length of stay is 17 days.
|
Insomnia Severity Index
Time Frame: baseline upon study admission
|
This questionnaire is a 7-item validated screening tool designed to assess the nature, severity, and impact of insomnia in adults.
|
baseline upon study admission
|
Stroke characteristics
Time Frame: baseline upon study admission
|
Because stroke characteristics can impact sleep, we will obtain participant data about type of stroke (hemorrhagic/ischemic), stroke location (per CT), stroke deficits (urinary incontinence, aphasia, etc.), stroke severity (based on the NIH Stroke Scale), and presence of recurrent stroke (obtained from chart audit).
|
baseline upon study admission
|
Pharmacologic sleep aids
Time Frame: baseline upon study admission
|
Using the electronic health record and a previously developed University of Chicago chart abstraction tool, a percentage of pharmacologic sleep aids used will be calculated.
|
baseline upon study admission
|
CPAP Adherence
Time Frame: Throughout 3 months of follow-up
|
For patients utilizing a CPAP, device adherence will be collected wirelessly through the device modem.
|
Throughout 3 months of follow-up
|
6-Minute Walk Test with VO2 analysis (6MWT)
Time Frame: Baseline; Within 7 days; Within 7 days of Discharge; at 1-month post discharge, 2-month post discharge, and 3-month post discharge Midpoint; Discharge; 1-month, 2-month, and 3-month follow up visits
|
The 6MWT measures the distance a subject can walk indoors on a flat, hard surface in 6 minutes, using assistive devices as necessary.
The test is a reliable and valid evaluation of functional exercise capacity and is used as a sub-maximal test of aerobic capacity and endurance.
The minimal detectable change for people with sub-acute stroke is 60.98 meters.
|
Baseline; Within 7 days; Within 7 days of Discharge; at 1-month post discharge, 2-month post discharge, and 3-month post discharge Midpoint; Discharge; 1-month, 2-month, and 3-month follow up visits
|
10-Meter Walk Test (10MWT)
Time Frame: Within 7 days; Within 7 days of Discharge; at 1-month post discharge, 2-month post discharge, and 3-month post discharge
|
The 10MWT measures the amount of time it takes to walk 10 meters.
Time will be recorded using a stopwatch and recorded to the one hundredth of a second.
The effects of acceleration and deceleration are minimized by adding 1 meter at the beginning and end of the course to isolate the subject's steady state speed.
The test will be recorded 3 times each at a normal self-selected pace and at a faster pace, with adequate rest in between.
Results will be averaged from 3 trials.
Any assistive devices or orthotics should be kept consistent throughout and documented.
|
Within 7 days; Within 7 days of Discharge; at 1-month post discharge, 2-month post discharge, and 3-month post discharge
|
Berg Balance Scale (BBS)
Time Frame: Baseline; Midpoint; Discharge; 1Within 7 days; Within 7 days of Discharge; at 1-month post discharge, 2-month post discharge, and 3-month post discharge-month, 2-month, and 3-month follow up visits
|
The BBS is a 14-item test, scored on a 5-level ordinal scale and validated against length of stay and discharge destination for stroke patients.
It measures functional balance in a clinical setting during static and dynamic tasks (sitting, standing, transitioning from sit to stand, etc.).
|
Baseline; Midpoint; Discharge; 1Within 7 days; Within 7 days of Discharge; at 1-month post discharge, 2-month post discharge, and 3-month post discharge-month, 2-month, and 3-month follow up visits
|
Timed Up and Go (TUG)
Time Frame: Baseline; Midpoint; Discharge; 1Within 7 days; Within 7 days of Discharge; at 1-month post discharge, 2-month post discharge, and 3-month post discharge-month, 2-month, and 3-month follow up visits
|
The TUG assesses mobility by measuring the time a person take to rise from a chair, walk 3 meters, turn around, walk back to the chair, and sit down.
It can detect longitudinal changes in mobility in stroke patients.
The subject wears their routine footwear and orthotics and can use their mobility aids.
|
Baseline; Midpoint; Discharge; 1Within 7 days; Within 7 days of Discharge; at 1-month post discharge, 2-month post discharge, and 3-month post discharge-month, 2-month, and 3-month follow up visits
|
Gait Analysis
Time Frame: Baseline; Midpoint; Within 7 days; Within 7 days of Discharge; at 1-month post discharge, 2-month post discharge, and 3-month post dischargeDischarge; 1-month, 2-month, and 3-month follow up visits
|
Gait analysis provides a quantitative means of assessing walking function based on spatiotemporal parameters of gait.
Subjects walk at both a comfortable and a fast pace over the GaitRite system, an electronic walkway with integrated sensors.
Data from GaitRite is reliable and valid for evaluating walking characteristics and provides a gold standard for validating gait parameters from the sensors.
For gait analysis, we will focus on 5 parameters: stride time, swing time, stance time, step length, and cadence.
|
Baseline; Midpoint; Within 7 days; Within 7 days of Discharge; at 1-month post discharge, 2-month post discharge, and 3-month post dischargeDischarge; 1-month, 2-month, and 3-month follow up visits
|
Montreal Cognitive Assessment (MoCA)
Time Frame: Performed once near admission to study
|
The 10-item MoCA assesses several cognitive domains.
These include short-term memory recall, visuospatial abilities, executive function, attention, concentration, language and orientation to time and place.
|
Performed once near admission to study
|
Wearable Sensor Platform Measures of Change in Sleep Staging
Time Frame: First three nights at study admission and last three nights before discharge.
|
Small multi-modality research-grade, wireless, and wearable sensors (eg.
MC10 Biostamp, ActiGraph, and ActiLink) will be used to calculate REM cycles without the use of PPG.
The MC10 or other wearable sensors can be placed simultaneously on body locations, collecting accelerometer, gyroscope, and bio-potential sensor data to provide a more in-depth analysis of heart rate variability across the night.
The ActiGraph and ActiLink can be worn on the wrist or waist to collect accelerometer, gyroscope, and magnetometer.
Actigraph management and data analysis are done using SRALab machine learning algorithms specific to stroke.
|
First three nights at study admission and last three nights before discharge.
|
Wearable Sensor Platform Measures of Change in Daytime Activity
Time Frame: Continuously during inpatient stay starting with study admission. Average length of stay is 17 days.
|
Small multi-modality research-grade, wireless, and wearable sensors (MC10 Biostamp, ActiGraph, and ActiLink) will be used to calculate objective measures of activity.
The MC10 can be placed simultaneously on body locations, and the ActiGraph and ActiLink are worn on the wrist, with all three collecting accelerometer and gyroscope data.
Actigraph management and data analysis are done using SRALab machine learning algorithms specific to stroke.
Raw acceleration data will be converted into a measure of step count.
|
Continuously during inpatient stay starting with study admission. Average length of stay is 17 days.
|
Change in wake after sleep onset time as measured by actigraphy
Time Frame: Overnight for first and last three nights of their stay. Average length of stay is 17 days.
|
Small multi-modality research-grade, wireless, and wearable sensors (Philips Actiwatch and Actigraph wGT3X-BT) are used to calculate total wake after sleep onset.
|
Overnight for first and last three nights of their stay. Average length of stay is 17 days.
|
Change in sleep efficiency as measured by actigraphy
Time Frame: Overnight for first and last three nights of their stay. Average length of stay is 17 days.
|
Small multi-modality research-grade, wireless, and wearable sensors (Philips Actiwatch and Actigraph wGT3X-BT) are used to calculate total sleep efficiency.
|
Overnight for first and last three nights of their stay. Average length of stay is 17 days.
|
Collaborators and Investigators
Sponsor
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Estimated)
Study Completion (Estimated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- SIESTA-Rehab
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Stroke
-
University Hospital, GhentRecruitingStroke | Stroke, Ischemic | Stroke, Acute | Stroke Sequelae | Stroke HemorrhagicBelgium
-
Moleac Pte Ltd.RecruitingStroke | Stroke, Ischemic | Stroke Sequelae | Stroke, Cardiovascular | Strokes Thrombotic | Stroke, Embolic | Stroke, CryptogenicSingapore, Philippines
-
Moleac Pte Ltd.Not yet recruitingStroke | Stroke, Ischemic | Stroke Sequelae | Stroke, Cardiovascular | Strokes Thrombotic | Stroke, Embolic | Stroke, Cryptogenic
-
IRCCS San Camillo, Venezia, ItalyRecruitingStroke | Stroke, Ischemic | Stroke Sequelae | Stroke HemorrhagicItaly
-
Vanderbilt University Medical CenterPatient-Centered Outcomes Research Institute; University of Alabama at BirminghamEnrolling by invitationStroke | Stroke, Ischemic | Stroke, Acute | Stroke Sequelae | Engagement, Patient | Stroke HemorrhagicUnited States
-
University of MinnesotaAmerican Occupational Therapy FoundationRecruitingStroke | Stroke Sequelae | Stroke Hemorrhagic | Stroke IschemicUnited States
-
University of British ColumbiaCanadian Institutes of Health Research (CIHR); Michael Smith Foundation for...RecruitingStroke | Stroke, Ischemic | Stroke Hemorrhagic | Chronic StrokeCanada
-
University of CincinnatiMedical University of South Carolina; University of California, Los Angeles; University...RecruitingStroke | Stroke, Ischemic | Stroke, Acute | Stroke HemorrhagicUnited States
-
Turkish Stroke Research and Clinical Trials NetworkElectroCore INC; Turkish Neurological SocietyCompletedStroke | Stroke, Ischemic | Stroke, Acute | Stroke, HemorrhagicTurkey
-
University of LiegeCompletedStroke, Acute | Stroke Hemorrhagic | Stroke, ComplicationBelgium
Clinical Trials on SIESTA Rehab Education
-
Medical College of WisconsinTerminatedIdiopathic Pulmonary FibrosisUnited States
-
Basque Health ServiceCompleted
-
Karolinska InstitutetRecruiting
-
Mayo ClinicNational Institute of Nursing Research (NINR)RecruitingHeart Failure | Acute Coronary Syndrome | Percutaneous Coronary Intervention | Stable Angina Pectoris | Acute Myocardial InfarctionUnited States
-
Emory UniversityAllerganCompleted
-
University of Michigan Rogel Cancer CenterRecruitingCardiovascular Diseases | Breast CancerUnited States
-
Orthopaedic Research FoundationDJO IncorporatedCompletedKnee OsteoarthritisUnited States
-
University of PittsburghMayo Clinic; University of Missouri-Columbia; Washington University School of... and other collaboratorsRecruitingKnee Dislocations | Multiple Ligament Knee InjuriesUnited States
-
University of MontanaUnited States Naval Medical Center, San Diego; Congressionally Directed Medical...RecruitingVestibular HypofunctionUnited States
-
University Hospital, GhentUniversity GhentNot yet recruiting