- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04272515
Molecular Characterization for Understanding Biliary Atresia (CAVB)
June 3, 2021 updated by: Institut National de la Santé Et de la Recherche Médicale, France
Although considered a rare disease, Biliary Atresia (BA) is the leading cause of neonatal cholestasis and liver transplantation in children.
Little is known about the molecular mechanisms that drive BA.
The purpose of this study is to collect the fluid samples, explanted liver tissue samples and dermal biopsy samples to enable investigators to perform the genetic and molecular analyses that might point to the gene(s) and cellular pathway involved in etiology of BA disease.
Study Overview
Status
Recruiting
Conditions
Intervention / Treatment
Detailed Description
Biliary atresia (BA) is a disease characterized by intra- and extra-hepatic bile duct obstruction diagnosed in the neonatal period.
If left untreated, this obstruction leads to biliary cirrhosis and early death.
Although considered a rare disease (between 1/15,000 and 1/20000 births), it is the leading cause of neonatal cholestasis and liver transplantation in children.
The reasons for this obstruction are still poorly known and might involve several factors (immune, infectious and possible toxin effect).
The accumulating evidence point to genetic factors involved, yet they are not of the classic monogenic or Mendelian types.
The purpose of this study is to collect the fluid samples, explanted liver tissue samples and dermal biopsy samples to enable investigators to perform the genetic and molecular analyses that might point to the gene(s) and cellular pathway involved in etiology of BA disease.
Study Type
Interventional
Enrollment (Anticipated)
100
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
-
Paris, France, 75013
- Not yet recruiting
- PRC Inserm
-
Contact:
- Ganna PANASYUK, Dr
- Phone Number: 0172606387
- Email: ganna.panasyuk@inserm.fr
-
-
De
-
Paris, De, France, 75015
- Recruiting
- Hopital Necker Enfants Malades
-
Contact:
- Muriel Girard, MD
- Phone Number: 01 44 49 44 12
- Email: muriel.girard@aphp.fr
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
- ADULT
- OLDER_ADULT
- CHILD
Accepts Healthy Volunteers
Yes
Genders Eligible for Study
All
Description
Inclusion Criteria:
- confirmed diagnosis of biliary atresia in patients
- parents of BA patients
Exclusion Criteria:
- no
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: BASIC_SCIENCE
- Allocation: NA
- Interventional Model: SINGLE_GROUP
- Masking: NONE
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
EXPERIMENTAL: BA patients and their parents
|
collection of blood sample for preparation of DNA
preparation of primary cultures of dermal fibroblasts from skin biopsy sample
cryoconservation of liver tissue for molecular analyses
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
To identify the molecular mechanisms implicated in the etiology of BA
Time Frame: 10 Years
|
To identify gene(s) and cellular pathways affected in cells and liver tissue of BA patients: sequencing experiments
|
10 Years
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (ACTUAL)
February 7, 2021
Primary Completion (ANTICIPATED)
February 7, 2026
Study Completion (ANTICIPATED)
February 7, 2032
Study Registration Dates
First Submitted
January 28, 2020
First Submitted That Met QC Criteria
February 13, 2020
First Posted (ACTUAL)
February 17, 2020
Study Record Updates
Last Update Posted (ACTUAL)
June 4, 2021
Last Update Submitted That Met QC Criteria
June 3, 2021
Last Verified
June 1, 2021
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- C19-36
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
NO
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Biliary Atresia
-
Sarah Magdy AbdelmohsenCompleted
-
RenJi HospitalUnknownBiliary Atresia Intrahepatic Syndromic FormChina
-
Children's Hospital of Fudan UniversityCompletedBiliary Atresia Congenital Type 3China
-
Yonsei UniversityCompletedBiliary Atresia, Kasai Portoenterostomy Status
-
Institute of Liver and Biliary Sciences, IndiaUnknownPortal Hypertension, Biliary AtresiaIndia
-
Intercept PharmaceuticalsNot yet recruiting
-
Weibing TangRecruiting
-
Holterman, Ai-Xuan, M.D.T Rose Clinical, Inc.; Big Leap Research; Prometheus USARecruitingBiliary AtresiaUnited States, Vietnam, Pakistan
-
AlbireoRecruitingBiliary AtresiaNetherlands, United States, Spain, Italy, Taiwan, Korea, Republic of, France, Germany, United Kingdom, Canada, Belgium, China, Australia, Poland, Turkey, Malaysia, New Zealand, Hungary, Israel
-
Arbor Research Collaborative for HealthNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)Recruiting
Clinical Trials on blood sampling
-
Medical University of GrazJoanneum Research Forschungsgesellschaft mbHCompleted
-
CardioRenalCompletedPotassium MeasurementBelgium
-
Centre Hospitalier Universitaire DijonCompletedPatients With Intellectual Disabilities Without an Obvious Clinical Diagnosis | Patients With Normal Array CGH and Previous Negative Genetic Investigations (WES-solo or WES-trio)France
-
Assistance Publique - Hôpitaux de ParisUnknownSepsis | Acute Circulatory FailureFrance
-
Assistance Publique Hopitaux De MarseilleCompleted
-
Rennes University HospitalCompletedMultiple SclerosisFrance
-
Institut PasteurSanofi Pasteur, a Sanofi Company; Institut Pasteur of Cote d'IvoireCompletedBordetella Pertussis, Whooping CoughCôte D'Ivoire
-
University Hospital, ToulouseCompletedPneumonia, PneumocystisFrance
-
Royal Surrey County Hospital NHS Foundation TrustCompletedThyroid Carcinoma | Thyroid Cancer | Cancer of the Thyroid | Cancer of ThyroidUnited Kingdom
-
Centre Hospitalier Universitaire DijonRecruiting