- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04596748
Oral Probiotics on the Microbiome and Lipidome in Acne Vulgaris
November 20, 2020 updated by: Raja Sivamani, Integrative Skin Science and Research
Prospective Randomized Double-Blind Placebo-Controlled Study of Oral Probiotics on the Microbiome and Lipidome in Acne Vulgaris
The purpose of this study is to determine how probiotics affect sebum production and gut health in those with acne vulgaris.
Study Overview
Status
Unknown
Conditions
Intervention / Treatment
Detailed Description
Probiotics have been shown in previous pilot studies to be helpful in acne and this study aims to examine how the gut microbiome and skin biophysical properties are shifted in those with acne vulgaris.
In particular, this study will assess the influence of oral spore based probiotics on the skin sebum production and will assess how probiotics influence the gut microbiome and the blood levels of short chain fatty acids.
Study Type
Interventional
Enrollment (Anticipated)
70
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
California
-
Sacramento, California, United States, 95815
- Recruiting
- Integrative Skin Science and Research
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
11 years to 43 years (Child, Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
- Subjects aged 13-45
- Subjects with acne vulgaris as diagnosed by a board-certified dermatologist,having mild-moderate acne on the face with an IGA score of 2-3 and 10+ inflammatory lesions on face and 15+ total lesions.
- Subjects should experience new acne lesions on a recurrent basis within last 6 months
- Must be willing to comply with all protocol requirements
- Must be willing to have flash photo facial images taken with the imaging systems
- Males must be willing to shave any facial hair
Exclusion Criteria:
- Any systemic antibiotics used to treat acne (injected or oral)within 6 months of starting study. Any 14-day or shorter course of systemic antibiotics (injected or oral) used to treat conditions other than acne within 1 month of starting study
- Any topical antibiotic or benzoyl peroxide within 1 month of starting study or any subject unwilling to refrain from washout of topical antibacterial or benzoyl peroxide ingredient.
- Any oral probiotic or prebiotic supplementation within past 1 month
- Subjects must have no history of malignancy or cancer or diagnosis of gastrointestinal inflammatory diseases, no history or diagnosis of epilepsy, no history or diagnosis of immunologic or infectious disease (e.g. hepatitis, tuberculosis, HIV or AIDS, lupus, rheumatoid arthritis)
- Has a condition or is on medication the investigator and/or designee believe could jeopardize the safety of the subject, interfere with the evaluation, or confound the interpretation of the study results
- Women who have been pregnant in the last three months, are pregnant, preparing to be pregnant or lactating, or post-menopausal.
- Is participating in a concurrent clinical research study or has participated in acne or other facial study at this or any other facility in the past 4 weeks
- Those with BMI higher than 35kg/m²
- Those that have undergone a change in hormonally based therapies, such as but not limited to oral contraceptive pills or progesterone based pills within the last two months. Progesterone releasing IUDs and spironolactone are considered hormone-based therapy.
- Commencement of a new diet (such as the ketogenic diet)or supplements within the 1 month prior to initiating participation, at the discretion of the investigator.
- Use of medications that alter blood lipids, such as statins and anti-hyperlipidemic medications
- Is participating in or has participated in acne or other facial study at this or any other facility in the past 4 weeks. Participation in survey-based studies are approved at the discretion of the investigator.
- Has a skin disease on face, other than acne, that will interfere with image collection and assessment in the opinion of the investigator
- Refusal to shave or remove facial hair that may interfere with image collection and assessment.
- Severe acne or nodulocystic acne, at the discretion of the investigator
- Use of isotretinoin within the 6 months prior to starting in study.
- Persons unwilling to avoid the following during the 4 weeks prior and during the duration of the study: self-tanning, spa tanning, or artificial tanning.
- Known allergy or irritation to the supplement or facial products utilized in the study
- Current tobacco smokers, OR those that have smoked tobacco over the past year, OR a 5 year-pack year history of smoking tobacco
- Prisoners
- Adults unable to consent
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Triple
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Placebo Comparator: Placebo
Participants will be taking a placebo supplement that they will be taking by mouth once per day.
|
Placebo caps
|
Experimental: Probiotic
Participants will be taking a probiotic supplement that they will be taking by mouth once per day.
|
Bacillus Subtilis, Bacillus Clausii, Bacillus Coagulans, Bacillus Indicus HU36, MCC 102
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Microbiota Diversity
Time Frame: 12 weeks
|
Evaluation of alpha diversity
|
12 weeks
|
Short chain fatty acids
Time Frame: 12 weeks
|
Blood plasma
|
12 weeks
|
Blood acetate levels
Time Frame: 12 weeks
|
Blood plasma
|
12 weeks
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Gut microbiome changes
Time Frame: 4 weeks and 8 weeks
|
Evaluation of alpha diversity
|
4 weeks and 8 weeks
|
Change in skin microbiome
Time Frame: 12 weeks
|
Relative abundance cutibacterium genera
|
12 weeks
|
Safety assessments for GI distress
Time Frame: 4 weeks, 8 weeks, 12 weeks
|
Self assessment using Digestive Questionnaire
|
4 weeks, 8 weeks, 12 weeks
|
Change in sebum excretion rate
Time Frame: 4 weeks, 8 weeks, 12 weeks
|
Sebumeter: 0-150 micrograms/cm^2
|
4 weeks, 8 weeks, 12 weeks
|
Change in skin hydration
Time Frame: 4,8 and 12 weeks
|
Moisturemeter: 0-150
|
4,8 and 12 weeks
|
Change in skin pH
Time Frame: 4,8, and 12 weeks
|
Use of pH meter
|
4,8, and 12 weeks
|
Facial redness - Image based
Time Frame: 4,8,12 weeks
|
BTBP Clarity Mini 3D camera
|
4,8,12 weeks
|
Facial skin tone - Image based
Time Frame: 4,8,12 weeks
|
BTBP Clarity Mini 3D camera
|
4,8,12 weeks
|
Subjective assessment of the skin
Time Frame: 4,8,12 weeks
|
Self-assessment through Dermatology Quality of Life questionnaire
|
4,8,12 weeks
|
Safety assessment of acne
Time Frame: 4, 8, 12 weeks
|
Evaluation of acne to assess for flares
|
4, 8, 12 weeks
|
Gut Microbiome Changes
Time Frame: 4, 8, 12 weeks
|
Relative abundance of Akkermansia muciniphila
|
4, 8, 12 weeks
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Collaborators
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
May 11, 2020
Primary Completion (Anticipated)
March 1, 2021
Study Completion (Anticipated)
March 1, 2021
Study Registration Dates
First Submitted
October 9, 2020
First Submitted That Met QC Criteria
October 15, 2020
First Posted (Actual)
October 22, 2020
Study Record Updates
Last Update Posted (Actual)
November 24, 2020
Last Update Submitted That Met QC Criteria
November 20, 2020
Last Verified
November 1, 2020
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- ISSR-Prob-GutSkin
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
No
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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