Peripheral Choroidal Layer Response

November 23, 2021 updated by: Geunyoung Yoon, University of Houston

Peripheral Choroidal Response to Pure Defocus and Oriented Blur Conditions

The study aims to examine how the vascular layer of the eyeball (choroidal layer) responds when part of the visual field is exposed to specially generated visual stimulus. The study goal will be accomplished by producing specific blur visual stimulus at a particular visual field position and measure any consistent thickness change pattern in the choroidal layer.

We propose to test the hypothesis that regional changes in the choroidal thickness may be induced differently after short-term exposure to specific visual stimuli.

Study Overview

Status

Not yet recruiting

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Anticipated)

40

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Contact Backup

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 40 years (Adult)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

All

Description

Inclusion Criteria:

A person is eligible for inclusion in the study if he/she:

  • Is between the ages of 18 and 40 yrs old
  • Has normal best corrected visual acuity being 20/20 or better
  • Has spherical refractive error between +1.00D and -6.00D.
  • Is capable of fixating on the target.
  • Has no prior ocular surgery.
  • Has no ocular pathology except keratoconus.
  • Can tolerate dilating eye drops

Exclusion Criteria:

A person will be excluded from the study if he/she:

  • Does not fall within above mentioned age group.
  • Has chronic or systemic eye disease that would interfere with pupil dilation via eye drops.
  • Underwent ocular surgeries or history of ocular trauma
  • Has shallow anterior chamber angle and/or glaucoma.
  • Has clinically significant dry eye.
  • Has signs of any choroidal or retinal pathology, and abnormalities in the visual pathway
  • Has spherical refractive error that exceeds the limits outlined above.
  • Has binocular anomalies (e.g. convergence insufficiency, strabismus, pseudo-myopia, amblyopia).
  • Is an adult unable to consent
  • Is an individual who is not yet adult (infants, children, teenagers)
  • Is a pregnant woman
  • Is a prisoner
  • Is a student for whom you have direct access to/influence on grades
  • Is an economically and/or educationally disadvantaged person

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Basic Science
  • Allocation: N/A
  • Interventional Model: Single Group Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: normal healthy group
Adaptive optics system: this system controls the optical quality of the eye at the peripheral visual field temporarily.
Device: adaptive optics system
the system consists of a wavefront sensor and a deformable mirror that measure and correct (or modify) the eye's optical imperfections (aberrations).

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
choroidal thickness
Time Frame: up to 60 mins
A commercially available optical coherence tomography system will be used to measure changes in choroidal layer thickness before and after manipulating the peripheral optics.
up to 60 mins

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University of Houston

Investigators

  • Principal Investigator: Geunyoung Yoon, PhD, University of Houston

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Anticipated)

November 1, 2021

Primary Completion (Anticipated)

November 1, 2022

Study Completion (Anticipated)

May 1, 2023

Study Registration Dates

First Submitted

November 11, 2021

First Submitted That Met QC Criteria

November 11, 2021

First Posted (Actual)

November 24, 2021

Study Record Updates

Last Update Posted (Actual)

November 30, 2021

Last Update Submitted That Met QC Criteria

November 23, 2021

Last Verified

November 1, 2021

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • STUDY00003210

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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