Analysis of Influencing Factors and Construction of Prediction Models of Artificial Joint Replacement in China

The project intends to analyze the epidemiological characteristics, risk factors, complications and resource utilization of artificial joint replacement in China through the inpatient data collected by the Hospital Quality Monitoring System (HQMS). The HQMS database is a mandatory electronic inpatient database system developed by the National Health Commission of the People's Republic of China. Since 2013, tertiary hospitals have been required to upload their inpatient discharge records. By 2019, the HQMS database has included more than 230 million standardized inpatient discharge records of over 1000 hospitals across all 31 provincial-level administrative regions in mainland China. Patient demographics, clinical diagnosis, procedures and operations, drug use, costs and complications were all recorded in the HQMS database. The investigators planned to include five types of arthroplasty, including knee arthroplasty, hip arthroplasty, shoulder arthroplasty, ankle arthroplasty and elbow arthroplasty. The data analysis will be conformed to the principle of confidentiality and will not reveal the privacy of those patients. The data will be only used for this research project and there is no conflict of interest. It is in line with the principles of ethics, harmlessness and fairness. This study was authorized by the HQMS Committee Board and approved by the institutional review board, with waiver of informed consent.

Study Overview

• Status: Active, not recruiting
• Conditions: Knee Arthropathy; Hip Arthropathy; Ankle Arthropathy; Elbow Arthropathy; Shoulder Arthropathy

• Study Type: Observational
• Enrollment (Anticipated): 600000

Contacts and Locations

Study Locations

• China
  • Hunan
    • Changsha, Hunan, China, 410008
      • Xiangya Hospital of Central South University

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Child; Adult; Older Adult
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

Patients who underwent knee, hip, shoulder, ankle and elbow arthroplasty were included.

Description

Inclusion Criteria:

• Patients who underwent knee, hip, shoulder, ankle and elbow arthroplasty in HQMS

Exclusion Criteria:

• Patients who didn't undergo knee, hip, shoulder, ankle and elbow arthroplasty
• Patients with missing demographics or medical data

Study Plan

How is the study designed?

Number of groups / cohorts

5

Cohorts and Interventions

Group / Cohort
patients undergoing knee arthroplasty in Hospital Quality Monitoring System in China; Patients who underwent knee arthroplasty and was recorded in HQMS were included in this group
patients undergoing hip arthroplasty in Hospital Quality Monitoring System in China; Patients who underwent hip arthroplasty and was recorded in HQMS were included in this group
patients undergoing shoulder arthroplasty in Hospital Quality Monitoring System in China; Patients who underwent shoulder arthroplasty and was recorded in HQMS were included in this group
patients undergoing ankle arthroplasty in Hospital Quality Monitoring System in China; Patients who underwent ankle arthroplasty and was recorded in HQMS were included in this group
patients undergoing elbow arthroplasty in Hospital Quality Monitoring System in China; Patients who underwent elbow arthroplasty and was recorded in HQMS were included in this group

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Epidemiological characteristics, complications, risk factors and resource utilization of knee arthroplasty in China	The project intends to analyze the epidemiological characteristics, complications, risk factors and resource utilization of artificial knee joint replacement in China through the inpatient data collected by the Hospital Quality Monitoring System (HQMS). The information collected by HQMS includes demographics characteristics, hospitalization information, medical care cost, complications, et al.	10 years (2013-2022)
Epidemiological characteristics, complications, risk factors and resource utilization of hip arthroplasty in China	The project intends to analyze the epidemiological characteristics, complications, risk factors and resource utilization of artificial hip joint replacement in China through the inpatient data collected by the Hospital Quality Monitoring System (HQMS). The information collected by HQMS includes demographics characteristics, hospitalization information, medical care cost, complications, et al.	10 years (2013-2022)
Epidemiological characteristics, complications, risk factors and resource utilization of shoulder arthroplasty in China	The project intends to analyze the epidemiological characteristics, complications, risk factors and resource utilization of artificial shoulder joint replacement in China through the inpatient data collected by the Hospital Quality Monitoring System (HQMS). The information collected by HQMS includes demographics characteristics, hospitalization information, medical care cost, complications, et al.	10 years (2013-2022)
Epidemiological characteristics, complications, risk factors and resource utilization of ankle arthroplasty in China	The project intends to analyze the epidemiological characteristics, complications, risk factors and resource utilization of artificial ankle joint replacement in China through the inpatient data collected by the Hospital Quality Monitoring System (HQMS). The information collected by HQMS includes demographics characteristics, hospitalization information, medical care cost, complications, et al.	10 years (2013-2022)
Epidemiological characteristics, complications, risk factors and resource utilization of elbow arthroplasty in China	The project intends to analyze the epidemiological characteristics, complications, risk factors and resource utilization of artificial elbow joint replacement in China through the inpatient data collected by the Hospital Quality Monitoring System (HQMS). The information collected by HQMS includes demographics characteristics, hospitalization information, medical care cost, complications, et al.	10 years (2013-2022)

Collaborators and Investigators

• Sponsor: Xiangya Hospital of Central South University
• Investigators: Principal Investigator: Guanghua Lei, PhD; MD, Xiangya Hospital

Publications and helpful links

General Publications

• Zeng C, Lane NE, Englund M, Xie D, Chen H, Zhang Y, Wang H, Lei G. In-hospital mortality after hip arthroplasty in China: analysis of a large national database. Bone Joint J. 2019 Oct;101-B(10):1209-1217. doi: 10.1302/0301-620X.101B10.BJJ-2018-1608.R1.

Study record dates

Study Major Dates

• Study Start (Actual): January 1, 2018
• Primary Completion (Anticipated): December 1, 2022
• Study Completion (Anticipated): December 1, 2022

Study Registration Dates

• First Submitted: December 8, 2021
• First Submitted That Met QC Criteria: December 8, 2021
• First Posted (Actual): December 27, 2021

Study Record Updates

• Last Update Posted (Actual): January 14, 2022
• Last Update Submitted That Met QC Criteria: December 30, 2021
• Last Verified: November 1, 2021

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Musculoskeletal Diseases; Joint Diseases
• Other Study ID Numbers: 2017121016

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO
• IPD Plan Description: The investigators do not wish to share our data according to the policy of our hospital, the data could not be shared with others without permission.

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No