- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT05243901
EPIPAGE 2 - 10-year Follow-up (RECONAI PROJECT) (EPIPAGE2)
EPIPAGE2 Cohort Study Follow up at Ten and a Half Years
Epipage 2 (Epidemiological study on small gestational ages) is a prospective population-based national cohort implemented to better understand the short, mid and long term future of premature children.
This study was launched on 28 March 2011 by the researchers of the EPOPé team (Perinatal, Obstetric and Pediatric Epidemiology Research) of the Epidemiology and Biostatistics Research Centre (INSERM U1153), in collaboration with the Inserm 1027 Unit (Epidemiology and Analysis in Public Health: risks, chronic diseases and handicaps) and medical teams of public health and research in 25 French regions.
The study focuses on children born before 35 weeks of amenorrhea.
3 follow-up steps for children included in the cohort have already been completed at 1, 2 and 5 and a half years of age. Currently, nearly 4,000 children are still eligible for follow-up.
Since the children are 9 years old, the follow-up steps are shared with those set up in another birth cohort, the Elfe cohort (Étude Longitudinale Française depuis l'Enfance, (www.elfe-france.fr) ), as part of the RE-CO-NAI project.
The RE-CO-NAI project is a research platform on cohorts of children followed since birth in order to be able to study in a global and multidisciplinary way the major issues of the health, development and socialization of children.
This RE-CO-NAI project was funded by the EQUIPEX 2011 call for projects as part of future investments.
This protocol, which is part of the RECONAI project, concerns the fully shared follow-up phase, proposed in the 10th year for the children of the two cohorts.
Study Overview
Status
Conditions
Detailed Description
The objectives of this new follow-up phase are to study:
- the relationships between prematurity, early growth and cardiometabolic disorders
- the relationship between parenting educational skills and children's quality of life
- the factors influencing children's puberty development
- the factors influencing the child's fitness and motor skills
Study design:
The 10 and a half year follow-up phase is a Category 2 Human Person Research (IHRP 2).
Study population The study population corresponds to all children who have participated in the Epipage 2 cohort since birth and whose parents did not wish to stop follow-up in the study. In total, nearly 4,000 children will be invited to participate in this new follow-up phase.
Methodology:
This follow-up phase will take place in 3 steps:
- A telephone interview with one of the parents living regularly with the child. Parents will be asked to answer several questions concerning their family situation, the school (homework, school support), the health, sleep and nutrition of the child, the general health and mental health of the parent interviewed, the employment situation, the living conditions and educational practices of the family.
The home visit of the families of an investigator who will propose to the families several activities:
- An interview with the child about his relations with his siblings, his comrades, his involvement in domestic activities and an estimate of his quality of life;
- A physical examination measuring some of the child's health parameters and including tests of physical fitness and motor skills;
- A test of the child's cognitive abilities;
- A parent self-administered questionnaire including a parent's cognitive abilities test (self-administered);
- Biological samples from the child (blood, urine, saliva hair)
Study Type
Enrollment (Anticipated)
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Description
Inclusion Criteria:
- Children initially included in the Epipage 2 study,
- Not lost to follow up (i.e. having participated in at least one of the Epipage 2 surveys since the age of 1 year),
- Neither parent has expressed a definitive refusal to participate in the follow-up study.
Exclusion Criteria:
- Refusal of the investigation by one of the two parents or holders of parental authority,
- Residence abroad
Study Plan
How is the study designed?
Design Details
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Relationships between prematurity, early growth and cardiometabolic disorders
Time Frame: 10 years and a half
|
Different cardiometabolic parameters will be studied (90th percentile waist for age and sex, 90th percentile systolic or diastolic pressure for age and sex)
|
10 years and a half
|
Relationship between parenting educational skills and children's quality of life
Time Frame: 10 years and a half
|
VSPA scale (Adolescent Experience and Perceived Health)
|
10 years and a half
|
Factors influencing children's puberty development
Time Frame: 10 years and a half
|
Tanner stage
|
10 years and a half
|
Factors influencing the child's fitness and motor skills
Time Frame: 10 years and a half
|
Children's Endurance and Motor Ability Test Results upper or equal to 75th percentile of distribution for sex
|
10 years and a half
|
Collaborators and Investigators
Study record dates
Study Major Dates
Study Start (ANTICIPATED)
Primary Completion (ANTICIPATED)
Study Completion (ANTICIPATED)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (ACTUAL)
Study Record Updates
Last Update Posted (ACTUAL)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- C20-68
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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