- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT05324085
Aerobic Exercise for Cognitive Functioning in Patients With Substance Use Disorder (SO_CogEx)
May 3, 2023 updated by: St. Olavs Hospital
Aerobic Exercise for Cognitive Functioning in Patients With Substance Use Disorder: a Randomized Controlled Trial
Impaired cognitive function is common among patients with substance use disorder (SUD).
This is particularly related to executive functions (EF), which includes abilities like decision-making, consequence analysis and impulse/self-control. EF is recognized as an important determinant of treatment outcome as it is associated with dropout rate, attendance to therapy sessions and absence of relapse following treatment termination.
Exercise seem to improve cognitive/executive functions, particularly in individuals with cognitive impairments.
Aerobic exercise also affects signaling substances and growth factors known to inhibit neural degeneration, and improves cerebral insulin sensitivity and blood flow, contributing to improved brain function.
There is a lack of knowledge regarding how to improve EF in SUD patients, and whether such improvements can benefit other parts of the treatment, such as psychotherapy.
Aerobic exercise is a well-recognized and cost-effective intervention for cardiovascular and metabolic health, with promising effects on cognitive/executive functions.
A randomized controlled trial will be carried out to investigate the effects of aerobic exercise on EF, molecular markers of neuroplasticity and brain function, and treatment outcome in SUD patients.
The investigators expect to achieve new knowledge regarding cognitive impairment among SUD patients and to what extent aerobic exercise can improve cognitive abilities and treatment outcome.
Study Overview
Status
Recruiting
Conditions
Intervention / Treatment
Study Type
Interventional
Enrollment (Anticipated)
90
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Contact
- Name: Mats P Mosti, PhD
- Phone Number: +4790193357
- Email: Mats.Peder.Mosti@stolav.no
Study Contact Backup
- Name: Carolin Haberstroh, MS
- Phone Number: +4748680392
- Email: Carolin.Haberstroh@stolav.no
Study Locations
-
-
Trøndelag
-
Trondheim, Trøndelag, Norway, 7041
- Recruiting
- Lade Behandlingssenter, Blåkors
-
Contact:
- Ragnhild Slettemoen, MS
- Email: Ragnhild.Slettemoen@blakors.no
-
Contact:
- Frode Kavli
- Email: frode.kavli@ladebs.no
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years and older (Adult, Older Adult)
Accepts Healthy Volunteers
No
Description
Inclusion Criteria:
- Diagnosed substance use disorder (SUD) by ICD-10
- Being in residential inpatient treatment for SUD at Lade Addiction Treatment Center
Exclusion Criteria:
- Recent participation in regular aerobic high-intensity interval training (HIIT)
- Admissions shorter than 12 weeks
- Pregnant
- History of brain injury (except concussions)
- Any acute or chronic somatic or psychiatric condition (e.g. heart disease or psychosis) or a medication that would limit the ability to participate in the exercise training and testing procedures, or any of the other assessments.
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Exercise intervention group
Participants will undergo supervised treadmill exercise three times each week for eight weeks, in addition to treatment as usual (TAU).
|
Supervised exercise intervention, three times a week for eight weeks.
Other Names:
The content of TAU is broadly individualized but most often includes various forms of group therapy, psychotherapy, psychoeducation and physical activity.
The physical activity schedule for the patients typically includes gym-based exercises, individualized by preference of each patient, and various outdoors activities, four times per week all together.
|
Other: Control group
Participants will undergo TAU.
The content of TAU is broadly individualized but most often includes various forms of group therapy, psychotherapy, psychoeducation and physical activity.
The physical activity schedule for the patients typically includes gym-based exercises, individualized by preference of each patient, and various outdoors activities, four times per week all together.
|
The content of TAU is broadly individualized but most often includes various forms of group therapy, psychotherapy, psychoeducation and physical activity.
The physical activity schedule for the patients typically includes gym-based exercises, individualized by preference of each patient, and various outdoors activities, four times per week all together.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Change in executive function (EF)
Time Frame: 8 weeks
|
Change in executive function assessed with Behavior Rating Inventory of ExecutiveFunction, Adult (BRIEF-A).
BRIEF-A is a 75-item standardized questionnaire appraising EFs in real-life situations.
It incorporates self-reported cognitive characteristics and collects subjective information about the ability to maintain appropriate control of emotional responses and behavior.
|
8 weeks
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Change in Montreal Cognitive Assessment (MoCA) score
Time Frame: 8 weeks
|
MoCA is a brief neuropsychological assessment to evaluate cognitive function in various domains (i.e.
visuospatial/executive abilities, naming, memory, attention, language, abstraction, and orientation).
This assessment takes about 10 minutes to perform.
Maximum score is 30, but scores from 26 and above is considered normal.
|
8 weeks
|
Change in Stroop test score
Time Frame: 8 weeks
|
Stroop is a widely used and validated test evaluate attention and impulse control.
This particular test allow 90 seconds to solve as many problems as possible.
Each correct answer provides one point, while incorrect answers are subtracted from the total score.
|
8 weeks
|
Change in Digit Span test performance
Time Frame: 8 weeks
|
The Digit Span test is an assessment of working memory, using rows of numbers that should be memorized.
Each correct answer provides one point with the following sequence being one digit longer than the previous.
The test has no limit on time or upper score, but only allows three mistakes before ending.
|
8 weeks
|
Altered serum concentration of Brain Derived Neurotrophic Factor (BDNF)
Time Frame: 8 weeks
|
BDNF is a biochemical marker of neurocognitive/neuroprotective mechanisms that can be measured in human serum
|
8 weeks
|
Altered serum concentration of Klotho
Time Frame: 8 weeks
|
Klotho is a biochemical marker of neurocognitive/neuroprotective mechanisms that can be measured in human serum
|
8 weeks
|
Altered serum concentration of glycosylphosphatidylinositol-specific phospholipase D1 (Gpld1)
Time Frame: 8 weeks
|
Gpld1 is a biochemical marker of neurocognitive/neuroprotective mechanisms that can be measured in human serum
|
8 weeks
|
Altered serum concentration of interleukin 6 (IL6)
Time Frame: 8 weeks
|
IL6 is a muscle-secreted protein known to affect neurocognitive/neuroprotective mechanisms
|
8 weeks
|
Change in maximal cardiorespiratory fitness
Time Frame: 8 weeks
|
Maximal cardiorespiratory fitness will be measured as oxygen uptake by cardiopulmonary exercise testing on a treadmill, by inclined walking or running on a treadmill
|
8 weeks
|
Change in mental distress
Time Frame: 8 weeks
|
Alterations in mental distress will be assessed using the validated brief questionnaire Symptom Checklist-10 (SCL-10)
|
8 weeks
|
Change in substance use
Time Frame: 8 weeks
|
Change in substance use will be assessed using a simple self-report questionnaire
|
8 weeks
|
Change in substance craving
Time Frame: 8 weeks
|
Change in substance use will be assessed using a simple Visual Analogue Scale ranging from 0 (no craving) to 10 (severe craving)
|
8 weeks
|
Change in quality of life
Time Frame: 8 weeks
|
Quality of life will be assessed with a brief version of the World Health Organization Quality of Life assessment
|
8 weeks
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Investigators
- Principal Investigator: Mats P Mosti, PhD, Department of Research and Development, St. Olavs University Hospital
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
April 7, 2022
Primary Completion (Anticipated)
December 1, 2024
Study Completion (Anticipated)
December 1, 2024
Study Registration Dates
First Submitted
April 4, 2022
First Submitted That Met QC Criteria
April 4, 2022
First Posted (Actual)
April 12, 2022
Study Record Updates
Last Update Posted (Estimate)
May 4, 2023
Last Update Submitted That Met QC Criteria
May 3, 2023
Last Verified
May 1, 2023
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 171845
- 3253020430 (Other Grant/Funding Number: Central Norway Regional Health Authority)
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
UNDECIDED
IPD Plan Description
Plan in progress
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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