- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT02706093
Metabolic Adaptations in Response to High Intensity Interval Training in Obese Adults (HT)
August 22, 2022 updated by: Jeffrey F Horowitz, University of Michigan
The overall objectives are to:
- Assess mechanisms underlying HIIT-induced improvements in insulin resistance at the whole-body, tissue, and cellular levels.
- Systematically compare different HIIT regimens to help identify effective "doses" of HIIT that may be optimal for improving metabolic health in obese adults.
- Assess the ability/willingness of obese subjects to adhere to a long-term HIIT program.
Findings from these studies will greatly expand knowledge about the effects of HIIT on metabolic health, and will provide valuable information for development of programs aimed at maximizing key metabolic benefits of exercise.
Study Overview
Status
Completed
Conditions
Detailed Description
If subjects are eligible for the study, they will be randomized into one of four different exercise training groups.
Before training (and twice after 3 months of training) subjects will participate in a "clinical study" in which they will be required to stay overnight in the hospital.
During the clinical study, the research team will perform a series of metabolic tests.
Before and after the 3 months of training, the research team will assess subjects "free-living" 24h blood sugar control using a Continuous Glucose Monitor (CGM).
The research team will measure several other relevant clinical markers (e.g., whole body and regional body fat assessments [Dual Energy X-ray Absorptiometry (DEXA) and Magnetic Resonance Imager (MRI)], hepatic lipid accumulation [MRI analysis], blood lipid profile, resting metabolic rate, glycated hemoglobin [hemoglobin A1c]).
After the first 3 months of training, adherence to the subjects assigned training program will be tracked for the next 9 months (1 year of training in total).
One year after initiating a training program, subjects will be asked to return to the clinic for a quick follow-up visit where the research team will complete some standard clinical assessments (e.g., body weight, body composition, blood pressure, and a blood sample).
Study Type
Interventional
Enrollment (Actual)
129
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
Michigan
-
Ann Arbor, Michigan, United States, 48178
- Suzette Howton
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years to 40 years (Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
- Age: 18-40
- Body Mass Index: 30-40 kg/m2
- Waist circumference: 88-98cm for women and 100-110cm for men
- Glucose intolerant (i.e., 2h glucose concentration during a screening oral glucose tolerance test (OGTT)= 140-199mg/dl
- No regularly planned exercise/physical activity
- Women must have regularly occurring menses and must be premenopausal
Exclusion Criteria:
- EKG abnormalities as assessed by the cardiologist on the research team
- Evidence/history of cardiovascular or metabolic disease
- Medications known to affect lipid or glucose metabolism
- Pregnant or lactating
- Tobacco or e-cigarette use
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Prevention
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Other: High Intensity Interval Training #1
Obese adults with impaired glucose tolerance will be randomized into one of four different exercise training groups for a 3 month exercise intervention.
|
(HIIT#1) 10 x 1 min.
at ~90%HRmax - with low intensity warm-up, recovery, and cool down - total of 25 min/session .
|
Other: Moderate intensity continuous training
Obese adults with impaired glucose tolerance will be randomized into one of four different exercise training groups for a 3 month exercise intervention.
|
Moderate-intensity continuous training (MICT) = steady-state exercise at 60-70%HRmax for 45min.
Representing a commonly prescribed exercise program.
|
Other: High Intensity Interval Training #2
Obese adults with impaired glucose tolerance will be randomized into one of four different exercise training groups for a 3 month exercise intervention.
|
(HIIT #2) 5 x 1 min at 90%HRmax + 10 min steady-state exercise at 70%HRmax [25min; ~150kcals; 4d/wk]
|
Other: High Intensity Interval Training #3
Obese adults with impaired glucose tolerance will be randomized into one of four different exercise training groups for a 3 month exercise intervention.
|
(HIIT #3) 5 x 1 min at 90%HRmax [15min; ~90kcals; 4d/wk]
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Insulin Sensitivity
Time Frame: Change from Baseline at 3 months
|
A hyperinsulinemic-euglycemic clamp will be used to assess peripheral insulin sensitivity
|
Change from Baseline at 3 months
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Continuous Glucose Monitoring
Time Frame: Change from Baseline at 3 months
|
Change from Baseline at 3 months
|
|
Resting Metabolic Rate
Time Frame: baseline and 3 months
|
baseline and 3 months
|
|
Muscle Biopsy
Time Frame: Change from Baseline at 3 months
|
To measure Mitochondrial Proteins
|
Change from Baseline at 3 months
|
Adipose Tissue Biopsy
Time Frame: Change from Baseline at 3 months
|
To measure cytokines
|
Change from Baseline at 3 months
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Investigators
- Principal Investigator: Jeff Horowitz, University of Michigan
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
May 3, 2016
Primary Completion (Actual)
May 4, 2022
Study Completion (Actual)
May 4, 2022
Study Registration Dates
First Submitted
March 2, 2016
First Submitted That Met QC Criteria
March 7, 2016
First Posted (Estimate)
March 11, 2016
Study Record Updates
Last Update Posted (Actual)
August 25, 2022
Last Update Submitted That Met QC Criteria
August 22, 2022
Last Verified
August 1, 2022
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- HUM00106883
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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