- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT05362708
Neurophysiological Correlates of Dissociation Induced by Virtual Reality Hypnosis (VRH) in a Clinical Population
Neurophysiological Correlates of Dissociation Induced by Virtual Reality Hypnosis (VRH) in an Oncological Population
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
The study will be focused on oncological patients undergoing a port-a-cath placement procedure. Day-1 and Day-2 with a one-day follow-up Day-3:
I. Day-1: Oncological Population (Feasibility)
1. Recruitment and questionnaires on the day of the port-a-cath preparation consultation (DAY-1): i. A medical screening will be performed to assess eligibility, ii. Elkins Hypnotizability Scale. iii. State Trait Anxiety Inventory-trait (anxiety trait) iv. Dissociative Experience Scale. v. Tellegen Absorption Scale. vi. Questionnaire of Immersion Propensity.
II. Day-2:
Intervention day:
i. Visual Analogy Scale:
- Anxiety.
- Pain. ii. 4-Electrodes EEG device from Oncomfort during port-a-cath (Port) placement procedure under Virtual Reality Hypnosis (VRH), combined standard monitoring (spO2, heart rate, etc.) iii. Adverse events will be recorded throughout the experiment iv. Visual Analogy Scale:
- Dissociation.
- Pain.
- Anxiety
- Absorption.
- Arousal/wakefulness.
- Automaticity v. Time Perception (open-ended question) vi. Presence questionnaire. vii. Satisfaction questionnaire.
Follow-up (DAY-3):
i. A follow-up questionnaire using the Brief Pain Inventory (BPI) French version will be sent to the patient one week after the intervention to measure outcomes.
Study Type
Enrollment (Anticipated)
Phase
- Not Applicable
Contacts and Locations
Study Contact
- Name: Aminata Bicego, PhD
- Phone Number: +3243663499
- Email: abicego@uliege.be
Study Contact Backup
- Name: Rodrigo Montenegro, PhD Student
- Phone Number: +3243662983
- Email: rmontenegro@uliege.be
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria: Subject more than 18 years old
Exclusion Criteria:
- Low auditory and/or visual acuity precludes the use of the device.
- Head or face wounds precluding the use of the device.
- Schizophrenia, dissociative disorder or any other psychiatric disorder.
- Non-proficiency in French (Research language).
- Patient under 18 years old.
- Phobia of deep water.
- Allergy to cutaneous electrodes.
- Chronic pain and/or chronic analgesics consumption.
- Medication affecting the autonomic nervous system.
- Dizziness.
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Supportive Care
- Allocation: Non-Randomized
- Interventional Model: Parallel Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Experimental group - VRH
Patients will receive VRH during port-a-cath (Port) placement
|
The VRH intervention will use the Aqua video session developed by Oncomfort during a port-a-cath procedure.
|
No Intervention: Control Group
Patients who do not want to receive the VRH but who accept to answer the questionnaires will be considered as a control group.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Dissociation state
Time Frame: During the procedure
|
Corresponds to a dissociation between the bodily sensations and the actual environment that one feels in a particular situation.
will be assessed with a numerical rating scale (0= no dissociation; 10 = dissociation from environment).
|
During the procedure
|
Pain intensity
Time Frame: During the procedure
|
The amount of pain one experiences in a particular situation.
Will be assessed with a visual analogy scale, 0= no pain at all; 10= worst pain imaginable.
|
During the procedure
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Dissociation trait
Time Frame: During the procedure
|
The amount of dissociation one experiences in one's daily life.
Will be assessed with the Dissociative Experience Scale, the higher the score, the more one experiences dissociation in one's daily life.
|
During the procedure
|
Hypnotisability
Time Frame: During the procedure
|
The susceptibility one has concerning hypnosis. Will be assessed with the Elkins Hypnotizability Scale. A score : 0-3 : low hypnotizability 4-7: medium hypnotizability 8-11 : high hypnotizability 12 : very high hypnotizability |
During the procedure
|
Absorption trait
Time Frame: During the procedure
|
The tendency to become fully involved in a perceptual, imaginative or ideational experience.
Will be assessed with the Tellegen Absorption Scale, the higher the score the higher the absorption in the daily life.
|
During the procedure
|
Anxiety trait
Time Frame: During the procedure
|
Level of anxiety one experiences in one's daily life.
Will be assessed with the State Trait Anxiety Invetory (STAI)-6 questionnaire.
The higher the score, the higher the anxiety one feels in one's daily life.
|
During the procedure
|
Immersion propensity (trait)
Time Frame: During the procedure
|
Immersion propensity is the amount of sensory input the virtual reality system creates.
Will be assessed with the Immersion Propensity questionnaire.
The higher the score, the more one is immersed in the virtual environments.
|
During the procedure
|
Anxiety state
Time Frame: During the procedure
|
The amount of anxiety one experiences in a particular situation.
Will be assessed with a visual analogy scale.
a score = 0 means no anxiety at all, while a score = 10 means most anxiety ever felt.
|
During the procedure
|
Absorption state
Time Frame: During the procedure
|
The amount of absorption one experiences in a particular situation.
Will be assessed with a numerical rating scale, 0 = no absorption; 10 = fully absorption by the experience.
|
During the procedure
|
Automaticity
Time Frame: During the procedure
|
A non-voluntary response related to the content of a communication that is intended to be a suggestion.
Will be assessed with a numerical rating scale : 0= perfect control; 10 = passive witness.
|
During the procedure
|
Arousal/wakefulness
Time Frame: During the procedure
|
The amount of arousal one experiences in a particular situation.
Will be assessed with a visual analogy scale, 0=not aroused, awaken; 10 = completely aroused, awake.
|
During the procedure
|
Time perception
Time Frame: During the procedure
|
Open-ended question about one's impression of the duration of the VHR and HYP sessions.
|
During the procedure
|
Cybersickness
Time Frame: During the procedure
|
Assesses the sickness one might experience after the VRH.
Will be assessed with the Cybersickness questionnaire.
The higher the score, the more one has experience sickness during the VRH.
|
During the procedure
|
Presence
Time Frame: During the procedure
|
Refers to the degree to which the subject experiences being in the virtual environment.
Will be assessed with the presence questionnaire, the higher the score the higher one has the feeling of really being in the virtual environment.
|
During the procedure
|
Satisfaction of the participant
Time Frame: During the procedure
|
Assesses the overall satisfaction one has had with the VRH and HYP session.
Will be assessed by a self-made satisfaction questionnaire, the higher the score, the more one is satisfied with the experience.
|
During the procedure
|
Brief Pain Inventory
Time Frame: One week after the procedure
|
The BPI measures the intensity of pain and interference of pain in the patient's life.
The higher the scores the higher the intensity and interference.
|
One week after the procedure
|
Collaborators and Investigators
Sponsor
Investigators
- Principal Investigator: Audrey ANHAUDENHUYSE, PhD, CHU of Liège
Study record dates
Study Major Dates
Study Start (Anticipated)
Primary Completion (Anticipated)
Study Completion (Anticipated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- QuDDoS - Phase-II
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
product manufactured in and exported from the U.S.
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