Neural Circuits for Action Perception

Study the mechanisms underlying action recognition and execution

Study Overview

• Status: Recruiting
• Conditions: Epilepsy
• Intervention / Treatment: Behavioral: Mechanisms of action perception and execution

Detailed Description

Subjects will participate in a task where they have to either

1. Perform a movement
2. Observe an actor performing a movement There are three types of actions including different kinematics and grip types The goal is to compare the neural circuits activated by action execution versus action observation.

• Study Type: Observational
• Enrollment (Anticipated): 30

Contacts and Locations

• Study Contact: Name: Gabriel Kreiman, PhD; Phone Number: 6179192530; Email: gabriel.kreiman@tch.harvard.edu

Study Locations

• United States
  • Massachusetts
    • Boston, Massachusetts, United States, 02115
      • Recruiting
      • Boston Children's Hospital
      • Contact: Dominguez Robleinscky; Phone Number: 617-919-2530; Email: domingues.robleinscky@childrens.harvard.edu
      • Contact: Gabriel Kreiman; Phone Number: 6179192242; Email: gabriel.kreiman@tch.harvard.edu

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 14 years to 70 years (Child, Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

Patients with pharmacologically intractable epilepsy undergoing invasive implantation of electrodes

Description

Inclusion Criteria:

• Patients with pharmacologically intractable epilepsy

Exclusion Criteria:

• Any situation that may put the patient at risk

Study Plan

How is the study designed?

Design Details

• Observational Models: Other
• Time Perspectives: Other

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Selectivity for kinematics and movement type in neurophysiological responses	Measure intracranial field potentials (in microvolts) in the gamma frequency band through neurophysiological responses comparing neural responses during action perception versus execution. We will assess selectivity for kinematics for each movement type	Through study completion, an average of 2 years.
Evoked responses by action execution	Measure intracranial field potentials (in microvolts) in the gamma frequency band through neurophysiological responses comparing neural responses during action perception versus execution. We will quantify responses evoked by action execution	Through study completion, an average of 2 years.
Evoked responses by action observation	Measure intracranial field potentials (in microvolts) in the gamma frequency band through neurophysiological responses comparing neural responses during action perception versus execution. We will quantify responses evoked by action observation	Through study completion, an average of 2 years.

Collaborators and Investigators

• Sponsor: Boston Children's Hospital
• Investigators: Principal Investigator: Gabriel Kreiman, PhD, CHB

Study record dates

Study Major Dates

• Study Start (Actual): September 1, 2021
• Primary Completion (Anticipated): September 1, 2025
• Study Completion (Anticipated): September 1, 2025

Study Registration Dates

• First Submitted: August 9, 2022
• First Submitted That Met QC Criteria: August 17, 2022
• First Posted (Actual): August 18, 2022

Study Record Updates

• Last Update Posted (Actual): August 18, 2022
• Last Update Submitted That Met QC Criteria: August 17, 2022
• Last Verified: August 1, 2022

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Epilepsy
• Other Study ID Numbers: IRB_P0405065R

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: No

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No