A Study to Evaluate Mezigdomide, Bortezomib and Dexamethasone (MEZIVd) Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM) (SUCCESSOR-1)

June 2, 2026 updated by: Celgene

A Phase 3, Two-Stage, Randomized, Multicenter, Open-Label Study Comparing Mezigdomide (CC-92480), Bortezomib and Dexamethasone (MEZIVd) Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) in Subjects With Relapsed or Refractory Multiple Myeloma (RRMM): SUCCESSOR-1

The purpose of this study is to compare the efficacy and safety of mezigdomide (CC-92480), bortezomib and dexamethasone (MeziVd) versus pomalidomide, bortezomib and dexamethasone (PVd) in participants with relapsed or refractory multiple myeloma (RRMM) who received between 1 to 3 prior lines of therapy and who have had prior lenalidomide exposure.

Study Overview

Status

Recruiting

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Estimated)

810

Phase

  • Phase 3

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

  • Name: First line of the email MUST contain NCT # and Site #.

Study Contact Backup

  • Name: BMS Clinical Trials Contact Center www.BMSClinicalTrials.com
  • Phone Number: 855-907-3286
  • Email: Clinical.Trials@bms.com

Study Locations

  • Argentina
      • Buenos Aires, Argentina, CP1280AEB
        • Active, not recruiting
        • Local Institution - 0214
    • Buenos Aires
      • Chivilcoy, Buenos Aires, Argentina, 6620
        • Active, not recruiting
        • Local Institution - 0318
    • Buenos Aires F.D.
      • Buenos Aires, Buenos Aires F.D., Argentina, 1425
        • Active, not recruiting
        • Local Institution - 0213
    • Córdoba Province
      • Córdoba, Córdoba Province, Argentina, 5016
        • Active, not recruiting
        • Local Institution - 0249
    • R
      • Viedma, R, Argentina, R8500ACE
        • Active, not recruiting
        • Local Institution - 0239
    • Santa Fe Province
      • Rosario, Santa Fe Province, Argentina, 2000
        • Active, not recruiting
        • Local Institution - 0200
      • S3000epv, Santa Fe Province, Argentina, 3000
        • Completed
        • Local Institution - 0248
  • Australia
    • New South Wales
      • Liverpool, New South Wales, Australia, 2170
        • Active, not recruiting
        • Local Institution - 0055
      • Waratah, New South Wales, Australia, 2298
        • Active, not recruiting
        • Local Institution - 0004
      • Wollongong, New South Wales, Australia, 2500
        • Active, not recruiting
        • Local Institution - 0017
    • Queensland
      • Birtinya, Queensland, Australia, 4575
        • Active, not recruiting
        • Local Institution - 0327
    • Victoria
      • Box Hill, Victoria, Australia, 3128
        • Active, not recruiting
        • Local Institution - 0221
      • Melbourne, Victoria, Australia, 3004
        • Active, not recruiting
        • Local Institution - 0003
      • Melbourne, Victoria, Australia, 3065
        • Active, not recruiting
        • Local Institution - 0002
    • Western Australia
      • Nedlands, Western Australia, Australia, 6009
        • Active, not recruiting
        • Local Institution - 0040
  • Austria
      • Krems, Austria, 3500
        • Recruiting
        • Universitätsklinikum Krems
        • Contact:
          • Klaus Podar, Site 0008
          • Phone Number: +43 2732 9004 22324
      • Leoben, Austria, 8700
        • Completed
        • Local Institution - 0024
      • Sankt Pölten, Austria, 3100
        • Recruiting
        • Universitätsklinikum St. Pölten
        • Contact:
          • Petra Pichler, Site 0011
          • Phone Number: 004327429004-22181
      • Vienna, Austria, 1140
        • Recruiting
        • Hanusch-Krankenhaus
        • Contact:
          • Michael Fillitz, Site 0025
          • Phone Number: +4319102157311
    • State of Vienna
      • Vienna, State of Vienna, Austria, 1160
        • Recruiting
        • Klinik Ottakring
        • Contact:
          • Thomas Spanberger, Site 0012
          • Phone Number: 066475113744
  • Belgium
      • Antwerp, Belgium, 2030
        • Recruiting
        • ZNA Cadix
        • Contact:
          • Ka Lung Wu, Site 0136
          • Phone Number: +32 3 2177392
    • Limburg
      • Genk, Limburg, Belgium, 3600
        • Recruiting
        • Ziekenhuis Oost-Limburg, Campus St.-Jan
        • Contact:
          • Natalie Put, Site 0138
          • Phone Number: +32 89 32 65 50
    • Oost-Vlaanderen
      • Ghent, Oost-Vlaanderen, Belgium, 9000
        • Recruiting
        • UZ Gent
        • Contact:
          • Nicolas Kint, Site 0206
          • Phone Number: 093324912
      • Sint-Niklaas, Oost-Vlaanderen, Belgium, B-9100
        • Recruiting
        • AZ Nikolaas
        • Contact:
          • Isabelle Vande Broek, Site 0179
          • Phone Number: +3237602985
  • Brazil
      • Rio de Janeiro, Brazil, 22793080
        • Recruiting
        • Americas Centro de Oncologia Integrado
        • Contact:
          • Angelo Maiolino, Site 0049
      • São Paulo, Brazil, 04537-080
        • Recruiting
        • Clinica Medica Sao Germano S/S LTDA
        • Contact:
          • Vania Hungria, Site 0050
          • Phone Number: +5511999346820
      • São Paulo, Brazil, 05652-900
        • Recruiting
        • Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein
        • Contact:
          • Nelson Hamerschlak, Site 0045
          • Phone Number: 551121513203
    • Estado de Bahia
      • Salvador, Estado de Bahia, Brazil, 40301-155
        • Recruiting
        • Instituto D'Or de Pesquisa e Ensino (IDOR) - Filial Salvador
        • Contact:
          • EDVAN CRUSOE, Site 0046
          • Phone Number: 557132816965
    • Rio Grande do Sul
      • Porto Alegre, Rio Grande do Sul, Brazil, 90110-270
        • Recruiting
        • Centro Gaucho Integrado De Oncologia, Hematologia, Ensino E Pesquisa
        • Contact:
          • Marcelo Capra, Site 0044
          • Phone Number: 5551999538883
    • Santa Catarina
      • Joinville, Santa Catarina, Brazil, 89202-050
        • Recruiting
        • Instituto Joinvilense de Hematologia e Oncologia
        • Contact:
          • Gabriela Gastal, Site 0314
          • Phone Number: 0000000000
    • São Paulo
      • Jaú, São Paulo, Brazil, 17210-080
        • Recruiting
        • Hospital Amaral Carvalho
        • Contact:
          • Ederson Mattos, Site 0305
          • Phone Number: 5514991337515
  • Canada
    • Quebec
      • Greenfield Park, Quebec, Canada, J4V 2H1
        • Active, not recruiting
        • Local Institution - 0225
      • Montreal, Quebec, Canada, H4J 1C5
        • Active, not recruiting
        • Local Institution - 0174
      • Québec, Quebec, Canada, G1J 1Z4
        • Active, not recruiting
        • Local Institution - 0222
  • Chile
    • Santiago Metropolitan
      • Santiago, Santiago Metropolitan, Chile, 7580206
        • Active, not recruiting
        • Local Institution - 0329
      • Santiago, Santiago Metropolitan, Chile, 8420383
        • Active, not recruiting
        • Local Institution - 0387
    • Valparaiso
      • Viña del Mar, Valparaiso, Chile
        • Active, not recruiting
        • Local Institution - 0332
  • China
      • Beijing, China, 100034
        • Completed
        • Local Institution - 0150
      • Taiyuan, China, 030032
        • Active, not recruiting
        • Local Institution - 0176
    • Beijing Municipality
      • Beijing, Beijing Municipality, China, 100043
        • Completed
        • Local Institution - 0165
      • Beijing, Beijing Municipality, China, 100091
        • Completed
        • Local Institution - 0141
      • Beijing, Beijing Municipality, China, 100043
        • Active, not recruiting
        • Local Institution - 0062
    • Chongqing Municipality
      • Chongqing, Chongqing Municipality, China, 400016
        • Active, not recruiting
        • Local Institution - 0144
    • Fujian
      • Xiamen, Fujian, China, 361003
        • Active, not recruiting
        • Local Institution - 0237
    • Guangdong
      • Guangzhou, Guangdong, China, 510080
        • Withdrawn
        • Local Institution - 0168
      • Guangzhou, Guangdong, China, 450008
        • Active, not recruiting
        • Local Institution - 0117
      • Guangzhou, Guangdong, China, 510060
        • Active, not recruiting
        • Local Institution - 0177
      • Shenzhen, Guangdong, China, 518039
        • Active, not recruiting
        • Local Institution - 0238
    • Guangxi
      • Liuzhou, Guangxi, China
        • Completed
        • Local Institution - 0412
      • Nanning, Guangxi, China, 530007
        • Active, not recruiting
        • Local Institution - 0240
    • Hebei
      • Shijiazhuang, Hebei, China, 50000
        • Active, not recruiting
        • Local Institution - 0254
    • Henan
      • Luoyang, Henan, China, 471003
        • Completed
        • Local Institution - 0395
      • Zhengzhou, Henan, China, 450003
        • Active, not recruiting
        • Local Institution - 0113
    • Hubei
      • Wuhan, Hubei, China, 430022
        • Active, not recruiting
        • Local Institution - 0142
    • Hunan
      • Changsha, Hunan, China, 410008
        • Active, not recruiting
        • Local Institution - 0155
      • Changsha, Hunan, China, 410013
        • Active, not recruiting
        • Local Institution - 0147
    • Jiangsu
      • Nanjing, Jiangsu, China, 210000
        • Active, not recruiting
        • Local Institution - 0111
      • Wuxi, Jiangsu, China, 214023
        • Active, not recruiting
        • Local Institution - 0139
    • Liaoning
      • Shenyang, Liaoning, China, 110004
        • Active, not recruiting
        • Local Institution - 0287
    • Shaanxi
      • Xi'an, Shaanxi, China, 710126
        • Completed
        • Local Institution - 0110
      • Xi'an, Shaanxi, China, 710004
        • Active, not recruiting
        • Local Institution - 0148
    • Shandong
      • Qingdao, Shandong, China, 266000
        • Completed
        • Local Institution - 0169
    • Shanghai Municipality
      • Shanghai, Shanghai Municipality, China, 200030
        • Active, not recruiting
        • Local Institution - 0114
      • Shanghai, Shanghai Municipality, China, 200434
        • Active, not recruiting
        • Local Institution - 0350
    • Shanxi
      • Taiyuan, Shanxi, China, 030001
        • Active, not recruiting
        • Local Institution - 0164
    • Sichuan
      • Deyang, Sichuan, China, 618000
        • Not yet recruiting
        • Local Institution - 0356
        • Contact:
          • Site 0356
    • Tianjin Municipality
      • Tianjin, Tianjin Municipality, China, 300060
        • Active, not recruiting
        • Local Institution - 0119
    • Xinjiang
      • Ürümqi, Xinjiang, China, 830001
        • Not yet recruiting
        • Local Institution - 0353
        • Contact:
          • Site 0353
    • Yunnan
      • Kunming, Yunnan, China, 650032
        • Active, not recruiting
        • Local Institution - 0202
    • Zhejiang
      • Hangzhou, Zhejiang, China, 310003
        • Withdrawn
        • Local Institution - 0151
      • Linhai, Zhejiang, China, 317000
        • Active, not recruiting
        • Local Institution - 0348
      • Ningbo, Zhejiang, China, 315010
        • Active, not recruiting
        • Local Institution - 0112
      • Wenzhou, Zhejiang, China, 32500
        • Active, not recruiting
        • Local Institution - 0149
  • Czechia
      • Prague, Czechia, 12808
        • Active, not recruiting
        • Local Institution - 0039
    • Brno-město
      • Brno, Brno-město, Czechia, 625 00
        • Active, not recruiting
        • Local Institution - 0037
    • Praha 10
      • Prague, Praha 10, Czechia, 100 34
        • Completed
        • Local Institution - 0383
  • Finland
      • Helsinki, Finland, 00029
        • Active, not recruiting
        • Local Institution - 0072
    • Northern Savonia
      • Kuopio, Northern Savonia, Finland, 70210
        • Active, not recruiting
        • Local Institution - 0256
  • France
      • Clermont-Ferrand, France, 63100
        • Recruiting
        • Centre Hospitalier Universitaire Estaing
        • Contact:
          • Anne Pascale Grandjean, Site 0116
          • Phone Number: 07 51 63 68 02
      • Limoges, France, 87042
        • Recruiting
        • Centre Hospitalier Universitaire de Limoges - Hôpital Dupuytren
        • Contact:
          • Murielle Roussel, Site 0167
          • Phone Number: +33531155050
      • Nantes, France, 44093
        • Recruiting
        • Centre Hospitalier Universitaire de Nantes - L' Hopital l'hôtel-Dieu
        • Contact:
          • Cyrille Touzeau, Site 0043
          • Phone Number: 33240083271
      • Nîmes, France, 30029
        • Recruiting
        • Centre Hospitalier Universitaire de Nîmes - Institut de Cancérologie du Gard - Hôpital Universitaire Carémeau
        • Contact:
          • Agathe WAULTIER RASCALOU, Site 0216
          • Phone Number: +33.4.66.68.40.33
      • Tours, France, 37032
        • Recruiting
        • Centre Hospitalier Régional Universitaire de Tours - Hôpital Bretonneau
        • Contact:
          • Thomas Chalopin, Site 0188
          • Phone Number: 0643879861
    • Alsace
      • Strasbourg, Alsace, France, 67033
        • Recruiting
        • Institut de cancérologie Strasbourg Europe (ICANS)
        • Contact:
          • Cécile SONNTAG, Site 0175
          • Phone Number: 0615175400
    • Aquitaine
      • Pessac, Aquitaine, France, 33600
        • Recruiting
        • CHU Bordeaux Haut-Leveque
        • Contact:
          • Cyrille Hulin, Site 0091
          • Phone Number: 33557656511
    • Auvergne-Rhône-Alpes
      • Lyon Cedex08, Auvergne-Rhône-Alpes, France, 69373
        • Recruiting
        • Centre Léon Bérard
        • Contact:
          • Philippe REY, Site 0205
          • Phone Number: +33426556802
    • Nord
      • Lille, Nord, France, 59000
        • Recruiting
        • Hopital Claude Huriez - CHU de Lille
        • Contact:
          • Salomon Manier, Site 0146
          • Phone Number: 33320444292
    • Île-de-France Region
      • Paris, Île-de-France Region, France, 75571
        • Recruiting
        • Hopital Saint Antoine
        • Contact:
          • Mohamad Mothy, Site 0115
          • Phone Number: +33240083271 000 00
  • Germany
      • Aachen, Germany, 52074
        • Recruiting
        • Universitätsklinikum Aachen
        • Contact:
          • Deniz Gezer, Site 0391
          • Phone Number: +49492418089770
      • Bamberg, Germany, 96049
        • Recruiting
        • Sozialstiftung Bamberg
        • Contact:
          • Christof Schweizer, Site 0390
          • Phone Number: 004995150313713
      • Dresden, Germany, 01307
        • Recruiting
        • Gemeinschaftspraxis Hämatologie - Onkologie Freiberg-Richter, Jacobasch, Illmer, Wolf
        • Contact:
          • Thomas Illmer, Site 0413
          • Phone Number: 00493514400022
      • Hamburg, Germany, 20251
        • Recruiting
        • Universitaetsklinikum Hamburg-Eppendorf
        • Contact:
          • Katja Weisel, Site 0015
          • Phone Number: 4940741058787
      • Hamburg, Germany, 22763
        • Recruiting
        • Asklepios Altona
        • Contact:
          • Hans-Jürgen Salwender, Site 0388
          • Phone Number: 49-40-181881-1273
      • Tübingen, Germany, 72076
        • Recruiting
        • Universitaetsklinikum Tuebingen
        • Contact:
          • Britta Besemer, Site 0010
          • Phone Number: 4970712982711
      • Würzburg, Germany, 97080
        • Recruiting
        • Gemeinschaftspraxis Dres. med. Björn Schöttker & Dominik Pretscher
        • Contact:
          • Dominik Pretscher, Site 0394
          • Phone Number: 0049931322670
    • Bavaria
      • München, Bavaria, Germany, 81675
        • Recruiting
        • TUM Klinikum
        • Contact:
          • Marion Hoegner, Site 0392
          • Phone Number: 498941405907
      • Traunstein, Bavaria, Germany, 83278
        • Recruiting
        • Klinikum Traunstein
        • Contact:
          • Matthias Egger, Site 0397
          • Phone Number: 00498617052595
      • Weiden, Bavaria, Germany, 92367
        • Recruiting
        • Medizinisches Versorgungszentrum
        • Contact:
          • Thomas Schichtl, Site 0393
          • Phone Number: +4930313660
    • Hesse
      • Marburg, Hesse, Germany, 35033
        • Recruiting
        • Universitätsklinikum Marburg
        • Contact:
          • Christoph Mann, Site 0059
          • Phone Number: 064215861413
    • Lower Saxony
      • Hanover, Lower Saxony, Germany, 30161
        • Recruiting
        • Praxis Onkologie am Raschplatz
        • Contact:
          • Eyck von der Heyde, Site 0414
          • Phone Number: 0177-6506614
    • North Rhine-Westphalia
      • Bonn, North Rhine-Westphalia, Germany, 53127
        • Recruiting
        • Universitatsklinikum Bonn
        • Contact:
          • Sebastian Schlaweck, Site 0092
          • Phone Number: 022828717000
      • Düsseldorf, North Rhine-Westphalia, Germany, 40479
        • Recruiting
        • Marien Hospital Dusseldorf
        • Contact:
          • Maika Klaiber-Hakimi, Site 0415
          • Phone Number: 021144006629
    • Schleswig-Holstein
      • Kiel, Schleswig-Holstein, Germany, 24105
        • Recruiting
        • Universitaetsklinikum Schleswig-Holstein Campus Kiel
        • Contact:
          • Natalie Schub, Site 0058
          • Phone Number: +49 431 500 22711
    • Thuringia
      • Erfurt, Thuringia, Germany, 99085
        • Not yet recruiting
        • Local Institution - 0396
        • Contact:
          • Site 0396
  • Greece
    • Attikí
      • Athens, Attikí, Greece, 106 76
        • Recruiting
        • Evangelismos General Hospital of Athens
        • Contact:
          • Sosana Delimpasi, Site 0190
          • Phone Number: 6944822722
      • Athens, Attikí, Greece, 115 28
        • Recruiting
        • Alexandra General Hospital of Athens
        • Contact:
          • MELETIOS DIMOPOULOS, Site 0191
          • Phone Number: +306932418798
    • Thessaloníki
      • Thessaloniki, Thessaloníki, Greece, 570 10
        • Recruiting
        • G. Papanikolaou General Hospital
        • Contact:
          • Ioanna Sakellari, Site 0189
          • Phone Number: 302313307550
  • India
      • Ludhiana, India, 141008
        • Recruiting
        • Christian Medical College & Hospital
        • Contact:
          • M Joseph John, Site 0343
          • Phone Number: 8054959525
      • Puducherry, India, 605006
        • Recruiting
        • Jawaharlal Institute of Postgraduate Medical Education and Research
        • Contact:
          • Biswajit Dubashi, Site 0345
          • Phone Number: 8056338305
    • Gujarat
      • Ahmedabad, Gujarat, India, 380060
        • Recruiting
        • HCG Aastha Cancer Centre
        • Contact:
          • Abhishek Dudhatra, Site 0342
          • Phone Number: 9978115559
    • Haryana
      • Gurugram, Haryana, India, 122011
        • Recruiting
        • Marengo Asia Hospitals Gurugram
        • Contact:
          • Meet Kumar, Site 0338
          • Phone Number: 09038791250
    • Karnataka
      • Belagavi, Karnataka, India, 590010
        • Recruiting
        • KLES Dr. Prabhakar Kore Hospital & M.R.C
        • Contact:
          • Rohan Bhise, Site 0336
          • Phone Number: 09448866712
    • Maharashtra
      • Mumbai, Maharashtra, India, 400036
        • Recruiting
        • Mumbai Oncocare Centre - Nanachowk
        • Contact:
          • Udip Maheshwari, Site 0416
          • Phone Number: 7677434237
    • Tamil Nadu
      • Madurai, Tamil Nadu, India, 625107
        • Completed
        • Local Institution - 0344
    • Uttar Pradesh
      • Varanasi, Uttar Pradesh, India, 221002
        • Completed
        • Local Institution - 0341
  • Ireland
      • Cork, Ireland, T12 E8YV
        • Active, not recruiting
        • Local Institution - 0122
      • Dublin, Ireland, D08 E9P6
        • Active, not recruiting
        • Local Institution - 0120
      • Limerick, Ireland, V94 F858
        • Withdrawn
        • Local Institution - 0251
    • Connacht
      • Galway, Connacht, Ireland, H91 YR71
        • Active, not recruiting
        • Local Institution - 0121
  • Israel
      • Peatch Tikva, Israel, 49100
        • Recruiting
        • Rabin Medical Center
        • Contact:
          • Iuliana Vaxman, Site 0194
          • Phone Number: +039738008
    • Central District
      • Kfar Saba, Central District, Israel, 4428164
        • Recruiting
        • Meir Medical Center
        • Contact:
          • Osnat Jarchowsky Dolberg, Site 0196
          • Phone Number: 972-50-5763994
      • Ramat Gan, Central District, Israel, 5262100
        • Recruiting
        • Sheba Medical Center
        • Contact:
          • Hila Magen, Site 0195
          • Phone Number: 972504065462
    • Jerusalem
      • Jerusalem, Jerusalem, Israel, 91220
        • Recruiting
        • Hadassah Medical Center - Do Not Use - Duplicate Facility
        • Contact:
          • Moshe Gatt, Site 0197
          • Phone Number: 97226779268
    • Northern District
      • Haifa, Northern District, Israel, 3109601
        • Recruiting
        • Rambam Health Care Campus
        • Contact:
          • Noa Lavi, Site 0192
          • Phone Number: 97248542541
    • Tall Abīb
      • Tel Aviv, Tall Abīb, Israel, 6423906
        • Recruiting
        • Sourasky Medical Center
        • Contact:
          • Yael Cohen, Site 0193
          • Phone Number: 972527360383
  • Italy
      • Bologna, Italy, 40138
        • Recruiting
        • IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola
        • Contact:
          • Elena Zamagni, Site 0159
      • Pavia, Italy, 27100
        • Recruiting
        • Fondazione IRCCS Policlinico San Matteo
        • Contact:
          • Silvia Mangiacavalli, Site 0158
          • Phone Number: +003903822501308
    • Emilia-Romagna
      • Meldola, Emilia-Romagna, Italy, 47014
        • Recruiting
        • IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori"
        • Contact:
          • Claudio Cerchione, Site 0384
          • Phone Number: +393475533565
    • Roma
      • Rome, Roma, Italy, 00189
        • Recruiting
        • Azienda Ospedaliera Sant'Andrea
        • Contact:
          • giacinto laverde, Site 0212
          • Phone Number: 0633775648
    • Sicily
      • Catania, Sicily, Italy, 95123
        • Recruiting
        • Policlinico "G. Rodolico"
        • Contact:
          • Francesco Di Raimondo, Site 0160
          • Phone Number: +39-0953781956
  • Japan
      • Chiba, Japan, 260-8677
        • Recruiting
        • Chiba University Hospital
        • Contact:
          • Emiko Sakaida, Site 0279
          • Phone Number: +81432227171
      • Fukuoka, Japan, 810-8563
        • Recruiting
        • National Hospital Organization Kyushu Medical Center
        • Contact:
          • Ken Takase, Site 0286
          • Phone Number: 81928520700
      • Fukuoka, Japan, 815-8555
        • Recruiting
        • Japanese Red Cross Fukuoka Hospital
        • Contact:
          • Kazuki Tanimoto, Site 0295
          • Phone Number: +81-92-521-1211
      • Hiroshima, Japan, 730-0052
        • Recruiting
        • Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital
        • Contact:
          • Mitsuhiro Itagaki, Site 0291
          • Phone Number: +81-82-241-3111
      • Kumamoto, Japan, 860-8556
        • Recruiting
        • Kumamoto University
        • Contact:
          • Yawara Kawano, Site 0284
          • Phone Number: +81-96-373-5156
      • Nagasaki, Japan, 852-8104
        • Recruiting
        • The Japanese Red Cross Nagasaki Genbaku Hospital
        • Contact:
          • Yasushi Sawayama, Site 0277
          • Phone Number: 095-847-1511
      • Tokyo, Japan, 150-8935
        • Recruiting
        • Japanese Red Cross Medical Center
        • Contact:
          • Tadao Ishida, Site 0283
          • Phone Number: 8133400104
      • Tokyo, Japan, 105-8461
        • Recruiting
        • The Jikei University Hospital
        • Contact:
          • Kazuhito Suzuki, Site 0300
          • Phone Number: +81-3-3433-1111
    • Chiba
      • Kashiwa, Chiba, Japan, 277-8577
        • Recruiting
        • National Cancer Center Hospital East
        • Contact:
          • Junichiro Yuda, Site 0281
          • Phone Number: 04-7133-1111
    • Fukuoka
      • Kitakyushu-shi, Fukuoka, Japan, 806-8501
        • Recruiting
        • Japan Community Healthcare Organization Kyushu Hospital
        • Contact:
          • Takanori Ohta, Site 0278
          • Phone Number: 093-641-5111
    • Hokkaido
      • Sapporo, Hokkaido, Japan, 003-0804
        • Recruiting
        • National Hospital Organization Hokkaido Cancer Center
        • Contact:
          • Katsuya Fujimoto, Site 0280
          • Phone Number: 81118119111
    • Ibaraki
      • Higashiibaraki, Ibaraki, Japan, 3113117
        • Recruiting
        • Mito Medical Center
        • Contact:
          • Takuya Komeno, Site 0417
          • Phone Number: 81292407711
    • Iwate
      • Shiwa-gun Yahaba-cho, Iwate, Japan, 028-3695
        • Recruiting
        • Iwate Medical University Hospital
        • Contact:
          • Shigeki Ito, Site 0276
          • Phone Number: 019-613-7111
    • Kanagawa
      • Kamakura, Kanagawa, Japan, 247-8533
        • Recruiting
        • Shonan Kamakura General Hospital
        • Contact:
          • Tomiteru Togano, Site 0294
          • Phone Number: +81-467-46-1717
    • Saitama
      • Iruma, Saitama, Japan, 350-0495
        • Recruiting
        • Saitama Medical University Hospital
        • Contact:
          • Yasuhito Terui, Site 0290
          • Phone Number: 81335200111
      • Koshigaya, Saitama, Japan, 343-0845
        • Recruiting
        • Dokkyo Medical University Saitama Medical Center
        • Contact:
          • Hideto Tamura, Site 0285
          • Phone Number: 048-965-1111
    • Shizuoka
      • Nagaizumi-cho,Sunto-gun, Shizuoka, Japan, 411-8777
        • Recruiting
        • Shizuoka Cancer Center
        • Contact:
          • Takashi Ikeda, Site 0289
          • Phone Number: 055-989-5222
    • Tokyo
      • Itabashiku, Tokyo, Japan, 173-8610
        • Recruiting
        • Nihon University Itabashi Hospital
        • Contact:
          • Katsuhiro Miura, Site 0296
          • Phone Number: +81-(0)3-3972-8111
  • New Zealand
      • Auckland, New Zealand, 2025
        • Withdrawn
        • Local Institution - 0334
      • Auckland, New Zealand, 1023
        • Active, not recruiting
        • Local Institution - 0369
    • Bay of Plenty
      • Tauranga, Bay of Plenty, New Zealand, 3112
        • Active, not recruiting
        • Local Institution - 0335
    • Otago
      • Dunedin, Otago, New Zealand, 9016
        • Active, not recruiting
        • Local Institution - 0340
  • Poland
      • Katowice, Poland, 40-519
        • Active, not recruiting
        • Local Institution - 0185
    • Greater Poland Voivodeship
      • Skórzewo, Greater Poland Voivodeship, Poland, 60-185
        • Withdrawn
        • Local Institution - 0346
    • Kuyavian-Pomeranian Voivodeship
      • Torun, Kuyavian-Pomeranian Voivodeship, Poland, 87-100
        • Completed
        • Local Institution - 0224
    • Lesser Poland Voivodeship
      • Krakow, Lesser Poland Voivodeship, Poland, 30-727
        • Not yet recruiting
        • Local Institution - 0325
        • Contact:
          • Site 0325
    • Masovian Voivodeship
      • Warsaw, Masovian Voivodeship, Poland, 02-776
        • Completed
        • Local Institution - 0250
    • Pomeranian Voivodeship
      • Słupsk, Pomeranian Voivodeship, Poland, 76-200
        • Completed
        • Local Institution - 0292
  • Portugal
      • Braga, Portugal, 4710-243
        • Recruiting
        • Hospital de Braga
        • Contact:
          • Herlander Marques, Site 0056
          • Phone Number: 00351 966041416
      • Lisbon, Portugal, 1400-038
        • Recruiting
        • Champalimaud Foundation
        • Contact:
          • Cristina João, Site 0014
      • Porto, Portugal, 4200-072
        • Recruiting
        • Instituto Português de Oncologia do Porto Francisco Gentil, EPE
        • Contact:
          • Angelo Martins, Site 0301
          • Phone Number: 351225084000
  • Puerto Rico
      • San Juan, Puerto Rico, 00909
        • Withdrawn
        • Local Institution - 0355
  • Romania
      • Bucharest, Romania, 022328
        • Recruiting
        • Fundeni Clinical Institute
        • Contact:
          • Sorina Badelita, Site 0021
          • Phone Number: 0040724238956
      • Cluj-Napoca, Romania, 400124
        • Recruiting
        • Institutul Oncologic Cluj
        • Contact:
          • Ciprian Tomuleasa, Site 0052
          • Phone Number: 0741337480
      • Iași, Romania, 700483
        • Recruiting
        • Institutul Regional de Oncologie Iasi
        • Contact:
          • Catalin Danaila, Site 0035
          • Phone Number: +40722565781
  • South Africa
    • GP
      • Centurion, GP, South Africa, 0044
        • Recruiting
        • Netcare Pretoria East Hospital
        • Contact:
          • LUCILLE SINGH, Site 0405
          • Phone Number: +27833976804
    • Western Cape
      • Cape Town, Western Cape, South Africa, 7925
        • Recruiting
        • Groote Schuur Hospital
        • Contact:
          • Estelle Verburgh, Site 0404
          • Phone Number: 27818502790
      • Kuilsriver, Western Cape, South Africa, 7580
        • Recruiting
        • Haemalife
        • Contact:
          • Michael Cass, Site 0407
          • Phone Number: +27219006277
      • Plumstead, Western Cape, South Africa, 7800
        • Recruiting
        • Constantiaberg Haematology
        • Contact:
          • Perry Loebenberg, Site 0406
          • Phone Number: 0217616600
  • South Korea
      • Seoul, South Korea, 03722
        • Recruiting
        • Severance Hospital, Yonsei University Health System
        • Contact:
          • Jin Seok Kim, Site 0090
          • Phone Number: 82222281972
      • Seoul, South Korea, 03722
        • Withdrawn
        • Local Institution - 0100
      • Seoul, South Korea, 138-736
        • Not yet recruiting
        • Local Institution
        • Contact:
          • Site 0082
    • Busan
      • Busan, Busan, South Korea, 49241
        • Withdrawn
        • Local Institution - 0106
      • Busan, Busan, South Korea, 49241
        • Recruiting
        • Pusan National University Hospital
        • Contact:
          • Ho-Jin Shin, Site 0087
          • Phone Number: 821089371258
    • Gyeonggido
      • Seongnam, Gyeonggido, South Korea, 13620
        • Withdrawn
        • Local Institution - 0102
      • Seongnam, Gyeonggido, South Korea, 13620
        • Recruiting
        • Seoul National University Bundang Hospital
        • Contact:
          • Ji Yun Lee, Site 0086
          • Phone Number: 82-10-6223-5401
    • Jeonranamdo
      • Hwasun, Jeonranamdo, South Korea, 58128
        • Recruiting
        • Chonnam National University Hwasun Hospital
        • Contact:
          • Sung Hoon Jung, Site 0085
          • Phone Number: 82613797623
      • Hwasun, Jeonranamdo, South Korea, 58128
        • Withdrawn
        • Local Institution - 0103
    • Seoul Teugbyeolsi
      • Seoul, Seoul Teugbyeolsi, South Korea, 03080
        • Withdrawn
        • Local Institution - 0101
      • Seoul, Seoul Teugbyeolsi, South Korea, 03080
        • Recruiting
        • Seoul National University Hospital
        • Contact:
          • Ja Min Byun, Site 0081
          • Phone Number: 821071243234
      • Seoul, Seoul Teugbyeolsi, South Korea, 06351
        • Recruiting
        • Samsung Medical Center
        • Contact:
          • Kihyun Kim, Site 0083
          • Phone Number: +821099333456
      • Seoul, Seoul Teugbyeolsi, South Korea, 06591
        • Withdrawn
        • Local Institution - 0104
      • Seoul, Seoul Teugbyeolsi, South Korea, 06591
        • Recruiting
        • The Catholic Univ. of Korea Seoul St. Mary's Hospital
        • Contact:
          • Chang Ki Min, Site 0084
          • Phone Number: 82-20-2258-6053
    • Seoul-teukbyeolsi
      • Seoul, Seoul-teukbyeolsi, South Korea, 05505
        • Withdrawn
        • Local Institution - 0105
    • Seoul-teukbyeolsi [Seoul]
      • Seoul, Seoul-teukbyeolsi [Seoul], South Korea, 05505
        • Recruiting
        • Asan Medical Center
        • Contact:
          • Dok Hyun Yoon, Site 0258
          • Phone Number: 82230105940
  • Spain
      • Cáceres, Spain, 10003
        • Active, not recruiting
        • Local Institution - 0328
      • León, Spain, 24071
        • Active, not recruiting
        • Local Institution - 0074
      • Madrid, Spain, 28041
        • Active, not recruiting
        • Local Institution - 0181
    • Balearic Islands
      • Palma, Balearic Islands, Spain, 07120
        • Withdrawn
        • Local Institution - 0183
    • Balears [Baleares]
      • Palma, Balears [Baleares], Spain, 07120
        • Active, not recruiting
        • Local Institution - 0252
    • Catalunya [Cataluña]
      • Barcelona, Catalunya [Cataluña], Spain, 08036
        • Withdrawn
        • Local Institution - 0073
      • Barcelona, Catalunya [Cataluña], Spain, 08036
        • Active, not recruiting
        • Local Institution - 0210
    • Murcia, Región de
      • Murcia, Murcia, Región de, Spain, 30008
        • Active, not recruiting
        • Local Institution - 0075
    • Málaga
      • Marbella, Málaga, Spain, 29603
        • Withdrawn
        • Local Institution - 0182
      • Marbella, Málaga, Spain, 29603
        • Active, not recruiting
        • Local Institution - 0253
  • Turkey (Türkiye)
      • Ankara, Turkey (Türkiye), 06620
        • Active, not recruiting
        • Local Institution - 0232
      • Ankara, Turkey (Türkiye), 06680
        • Active, not recruiting
        • Local Institution - 0339
      • Istanbul, Turkey (Türkiye), 34093
        • Active, not recruiting
        • Local Institution - 0228
      • Izmir, Turkey (Türkiye), 35100
        • Active, not recruiting
        • Local Institution - 0229
      • Kayseri, Turkey (Türkiye)
        • Active, not recruiting
        • Local Institution - 0226
      • Samsun, Turkey (Türkiye), 55139
        • Active, not recruiting
        • Local Institution - 0227
  • United Kingdom
      • Barnet, United Kingdom, EN5 3DJ
        • Recruiting
        • Barnet Hospital
        • Contact:
          • Huw Richards, Site 0304
          • Phone Number: 0208 216 4925
      • Newcastle upon Tyne, United Kingdom, NE7 7DN
        • Recruiting
        • Freeman Hospital
        • Contact:
          • Jennifer Young, Site 0124
          • Phone Number: 01912336161
      • Stoke-on-Trent, United Kingdom, ST4 6QG
        • Recruiting
        • Royal Stoke University Hospital
        • Contact:
          • Kamaraj Karunanithi, Site 0217
          • Phone Number: +441782674285
    • Cambridgeshire
      • Cambridge, Cambridgeshire, United Kingdom, CB2 0QQ
        • Recruiting
        • Addenbrooke's Hospital
        • Contact:
          • Marquita Camilleri, Site 0326
          • Phone Number: 44(0) 1223 596297
    • England
      • Truro, England, United Kingdom, TR1 3LJ
        • Recruiting
        • The Royal Cornwall Hospital
        • Contact:
          • Adam Forbes, Site 0218
          • Phone Number: 01872252765
    • Great Britain
      • Airdrie, Great Britain, United Kingdom, ML6 OJS
        • Recruiting
        • Lanarkshire NHS Trust - Monklands Hospital
        • Contact:
          • Iain Singer, Site 0127
          • Phone Number: 01236 712754
    • Greater London
      • London, Greater London, United Kingdom, SE5 9RS
        • Recruiting
        • King's College Hospital
        • Contact:
          • Kirsty Cuthill, Site 0128
          • Phone Number: 44 (0) 20 3299 5501
    • Leicestershire
      • Leicester, Leicestershire, United Kingdom, LE1 5WW
        • Recruiting
        • Leicester Royal Infirmary
        • Contact:
          • Shelina Sachedina, Site 0131
          • Phone Number: 01162586617
    • London, City of
      • London, London, City of, United Kingdom, W12 0HS
        • Recruiting
        • Hammersmith Hospital
        • Contact:
          • Aristeidis Chaidos, Site 0367
          • Phone Number: 02033133236
  • United States
    • California
      • Los Alamitos, California, United States, 90720
        • Active, not recruiting
        • Local Institution - 0366
      • San Diego, California, United States, 92123
        • Completed
        • Local Institution - 0272
      • West Hollywood, California, United States, 90069
        • Completed
        • Local Institution - 0273
    • Colorado
      • Aurora, Colorado, United States, 80045
        • Not yet recruiting
        • Local Institution - 0381
        • Contact:
          • Site 0381
    • Connecticut
      • Farmington, Connecticut, United States, 06030
        • Completed
        • Local Institution - 0380
      • New Haven, Connecticut, United States, 06510
        • Withdrawn
        • Local Institution - 0208
    • Florida
      • Coral Springs, Florida, United States, 33321
        • Active, not recruiting
        • Local Institution - 0303
      • Fort Myers, Florida, United States, 33901
        • Active, not recruiting
        • Local Institution - 0403
      • St. Petersburg, Florida, United States, 33701
        • Active, not recruiting
        • Local Institution - 0401
      • West Palm Beach, Florida, United States, 33401
        • Active, not recruiting
        • Local Institution - 0402
    • Georgia
      • Athens, Georgia, United States, 30607
        • Active, not recruiting
        • Local Institution - 0211
      • Marietta, Georgia, United States, 30060
        • Withdrawn
        • Local Institution - 0048
    • Kansas
      • Garden City, Kansas, United States, 67846
        • Completed
        • Local Institution - 0330
      • Westwood, Kansas, United States, 66205
        • Active, not recruiting
        • Local Institution - 0080
    • Louisiana
      • Baton Rouge, Louisiana, United States, 70808
        • Active, not recruiting
        • Local Institution - 0358
      • New Orleans, Louisiana, United States, 70112
        • Active, not recruiting
        • Local Institution - 0255
      • Shreveport, Louisiana, United States, 71103
        • Not yet recruiting
        • Local Institution - 0385
        • Contact:
          • Site 0385
    • Maryland
      • Baltimore, Maryland, United States, 21215
        • Active, not recruiting
        • Local Institution - 0357
    • Massachusetts
      • Boston, Massachusetts, United States, 02215
        • Active, not recruiting
        • Local Institution - 0246
    • Michigan
      • Ann Arbor, Michigan, United States, 48109
        • Active, not recruiting
        • Local Institution - 0271
      • Detroit, Michigan, United States, 48202
        • Active, not recruiting
        • Local Institution - 0364
    • Minnesota
      • Minneapolis, Minnesota, United States, 55404
        • Active, not recruiting
        • Local Institution - 0410
    • Mississippi
      • Hattiesburg, Mississippi, United States, 39401
        • Completed
        • Local Institution - 0088
      • Jackson, Mississippi, United States, 39213
        • Withdrawn
        • Local Institution - 0242
    • New Jersey
      • East Brunswick, New Jersey, United States, 08816
        • Active, not recruiting
        • Local Institution - 0288
      • Ridgewood, New Jersey, United States, 07450
        • Not yet recruiting
        • Local Institution - 0363
        • Contact:
          • Site 0363
    • New Mexico
      • Albuquerque, New Mexico, United States, 87131
        • Active, not recruiting
        • Local Institution - 0302
    • New York
      • Buffalo, New York, United States, 14215
        • Withdrawn
        • Local Institution - 0245
      • Lake Success, New York, United States, 11042
        • Active, not recruiting
        • Local Institution - 0257
      • New Hyde Park, New York, United States, 11042
        • Completed
        • Local Institution - 0373
      • New York, New York, United States, 10028
        • Completed
        • Local Institution - 0371
      • Rochester, New York, United States, 14621
        • Active, not recruiting
        • Local Institution - 0108
      • Shirley, New York, United States, 11967
        • Active, not recruiting
        • Local Institution - 0374
      • The Bronx, New York, United States, 10469
        • Completed
        • Local Institution - 0372
      • Williamsville, New York, United States, 14221
        • Withdrawn
        • Local Institution - 0274
    • North Carolina
      • Durham, North Carolina, United States, 27710
        • Active, not recruiting
        • Local Institution - 0260
    • Ohio
      • Cincinnati, Ohio, United States, 45242
        • Active, not recruiting
        • Local Institution - 0400
      • Cleveland, Ohio, United States, 44111
        • Active, not recruiting
        • Local Institution - 0377
      • Cleveland, Ohio, United States, 44195
        • Active, not recruiting
        • Local Institution - 0076
      • Mayfield Heights, Ohio, United States, 44124
        • Active, not recruiting
        • Local Institution - 0376
    • Pennsylvania
      • Allentown, Pennsylvania, United States, 18103
        • Completed
        • Local Institution - 0359
      • York, Pennsylvania, United States, 17403
        • Completed
        • Local Institution - 0264
    • Tennessee
      • Germantown, Tennessee, United States, 38138
        • Active, not recruiting
        • Local Institution - 0223
    • Texas
      • Abilene, Texas, United States, 79606
        • Active, not recruiting
        • Local Institution - 0378
      • Houston, Texas, United States, 77030
        • Active, not recruiting
        • Local Institution - 0275
      • San Antonio, Texas, United States, 78229
        • Active, not recruiting
        • Local Institution - 0267
      • San Antonio, Texas, United States, 78240
        • Active, not recruiting
        • Local Institution - 0409
    • Utah
      • Salt Lake City, Utah, United States, 84106
        • Active, not recruiting
        • Local Institution - 0207
    • Virginia
      • Fredericksburg, Virginia, United States, 22408
        • Active, not recruiting
        • Local Institution - 0297
      • Norfolk, Virginia, United States, 23502
        • Active, not recruiting
        • Local Institution - 0408
      • Roanoke, Virginia, United States, 24014
        • Active, not recruiting
        • Local Institution - 0399
    • Washington
      • Seattle, Washington, United States, 98109
        • Withdrawn
        • Local Institution - 0293
      • Seattle, Washington, United States, 98108
        • Active, not recruiting
        • Local Institution - 0268
      • Spokane, Washington, United States, 99208
        • Withdrawn
        • Local Institution - 0097
      • Vancouver, Washington, United States, 98684
        • Active, not recruiting
        • Local Institution - 0411
    • Wisconsin
      • Madison, Wisconsin, United States, 53792
        • Withdrawn
        • Local Institution - 0220

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

No

Description

Inclusion Criteria

- Participant has documented diagnosis of MM and measurable disease, defined as any of the following:.

i) M-protein ≥ 0.5 grams per deciliter (g/dL) by serum protein electrophoresis (sPEP) or.

ii) M-protein ≥ 200 milligrams (mg) per 24-hour urine collection by urine protein electrophoresis (uPEP).

iii) For participants without measurable disease in sPEP or uPEP: serum free light chain (sFLC) levels > 100 mg/L (10 mg/dL) involved light chain and an abnormal kappa/lambda FLC ratio.

  • Participants received 1 to 3 prior lines of antimyeloma therapy.
  • Participants achieved minimal response [MR] or better to at least 1 prior antimyeloma therapy.

Exclusion Criteria

- Participant has had progression during treatment or within 60 days of the last dose of a proteasome inhibitor, except as noted below:.

i) Subjects who progressed while being treated with, or within 60 days of last dose of bortezomib maintenance given once every 2 weeks (or less frequently) are not excluded.

ii) Participants who progressed while being treated with ixazomib monotherapy maintenance ≥ 6 months prior to the time of starting study treatment are not excluded.

  • For participants with prior treatment of a bortezomib containing regimen, the best response achieved was not a minimal response (MR) or better, or participant discontinued bortezomib due to toxicity.
  • Participant has had prior treatment with mezigdomide or pomalidomide.
  • Other protocol-defined Inclusion/Exclusion criteria apply.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: PVd (pomalidomide, bortezomib and dexamethasone)
Drug: Bortezomib
Specified dose on specified days
Other Names:
  • Velcade
  • BTZ
Drug: Dexamethasone
Specified dose on specified days
Other Names:
  • Decadron
  • Dex
Drug: Pomalidomide
Specified dose on specified days
Other Names:
  • Pomalyst
  • Imnovid
  • Pom
Experimental: MeziVd (mezigdomide, bortezomib and dexamethasone)
Drug: Bortezomib
Specified dose on specified days
Other Names:
  • Velcade
  • BTZ
Drug: Dexamethasone
Specified dose on specified days
Other Names:
  • Decadron
  • Dex
Drug: mezigdomide
Specified dose on specified days
Other Names:
  • BMS-986348
  • CC-92480

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Progression-free Survival (PFS)
Time Frame: From date of randomization to date of disease progression or death due to any cause (Up to approximately 5 years)
From date of randomization to date of disease progression or death due to any cause (Up to approximately 5 years)

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Overall Survival (OS)
Time Frame: From date of randomization to date of death due to any cause (Up to approximately 5 years)
From date of randomization to date of death due to any cause (Up to approximately 5 years)
Time to Response (TTR)
Time Frame: Up to approximately 5 years
Up to approximately 5 years
Duration of Response (DOR)
Time Frame: Up to approximately 5 years
Up to approximately 5 years
Time to Progression (TTP)
Time Frame: Up to approximately 5 years
Up to approximately 5 years
Time to Next Treatment (TTNT)
Time Frame: Up to approximately 5 years
Up to approximately 5 years
Progression-free Survival 2 (PFS-2)
Time Frame: Up to approximately 5 years
Up to approximately 5 years
Number of participants with Adverse Events (AEs)
Time Frame: Up to approximately 5 years
Up to approximately 5 years
Change from baseline in European Organization for Research and Treatment of Cancer - Quality of Life C30 questionnaire (EORTC QLQ-C30) scores
Time Frame: Up to approximately 5 years
The EORTC QLQ-C30 is the most commonly used quality of life instrument in oncology trials. The QLQ-C30 consists of 30 questions incorporated into 5 functional domains physical, role, cognitive, emotional, and social), 9 symptom/other scales (fatigue, pain, nausea and vomiting, dyspnea, insomnia, appetite loss, constipation, diarrhea, and financial difficulties), and a single global Quality of Life (QoL)/global health status score. Items in the functional and symptom scale use raw participant response of 1 to 4, where 1 = "not at all" and 4 = "very much." The 2 global items contain responses ranging from 1 "very poor" to 7 "excellent." The recall period is 1 week. All domain scores are transformed in a range from 0 to 100, where a higher functional score indicates more favorable outcomes and a higher score on the symptom domains indicates a less favorable participant outcome. Stage 2 only.
Up to approximately 5 years
Change from baseline in European Organization for Research and Treatment of Cancer - Quality of Life Multiple Myeloma Module (EORTC QLQ-MY20) score
Time Frame: Up to approximately 5 years
The EORTC QLQ-MY20 is a 20-item myeloma module intended for use among participants varying in disease stage and treatment modality. Participants rate symptoms or problems on a scale from 1 to 4 where 1 = "not at all" and 4 = "very much." Stage 2 only.
Up to approximately 5 years
Recommended mezigdomide dose
Time Frame: Up to 12 Months
Stage 1 only
Up to 12 Months
Plasma concentrations of mezigdomide
Time Frame: Up to 134 Days
Stage 1 only
Up to 134 Days
Overall Response (OR)
Time Frame: Up to approximately 5 years
OR is defined as the number of participants who achieve best response of partial response (PR) or better according to the International Myeloma Working Group (IMWG) Response Criteria for Multiple Myeloma
Up to approximately 5 years
Complete Response (CR) or better
Time Frame: Up to approximately 5 Years
Defined as the number of participants who achieve best response of complete response (CR) or better according to the IMWG Uniform Response Criteria for Multiple Myeloma
Up to approximately 5 Years
Very Good Partial Response (VGPR) or better
Time Frame: Up to approximately 5 years
Defined as the number of participants who achieve best response of very good partial response (VGPR) or better according to the IMWG Uniform Response Criteria for Multiple Myeloma
Up to approximately 5 years
Minimal Residual Disease (MRD) negativity
Time Frame: Up to approximately 5 years
Defined as the number of participants who achieve complete response (CR) or better and MRD negativity (defined as less than 1 in 10^5 nucleated cells [by next generation flow cytometry] in bone marrow aspirate)
Up to approximately 5 years

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Celgene

Investigators

  • Study Director: Bristol-Myers Squibb, Bristol-Myers Squibb

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

Helpful Links

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

September 20, 2022

Primary Completion (Estimated)

January 10, 2027

Study Completion (Estimated)

November 30, 2033

Study Registration Dates

First Submitted

August 25, 2022

First Submitted That Met QC Criteria

August 25, 2022

First Posted (Actual)

August 29, 2022

Study Record Updates

Last Update Posted (Actual)

June 3, 2026

Last Update Submitted That Met QC Criteria

June 2, 2026

Last Verified

June 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • CA057-001
  • 2023-509859-13 (Other Identifier: EU CTR)

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

YES

IPD Plan Description

BMS will provide access to individual anonymized participant data upon request from qualified researchers, and subject to certain criteria. Additional information regarding Bristol Myer Squibb's data sharing policy and process can be found at https://www.bms.com/researchers-and-partners/clinical-trials-and-research.html

IPD Sharing Time Frame

See Plan Description

IPD Sharing Access Criteria

See Plan Description

IPD Sharing Supporting Information Type

  • STUDY_PROTOCOL
  • SAP
  • CSR

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

Yes

Studies a U.S. FDA-regulated device product

No

product manufactured in and exported from the U.S.

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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