- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT05666674
Software-based Modification of Hand Tremors in XR
December 18, 2022 updated by: eMalick G. Njie, NeuroStorm, Inc
The following trial evaluates the effect of Tremor Stabilization Algorithms on involuntary hand tremors suffered by Parkinson's patients.
These algorithms will be implemented in Virtual Reality (VR).
Approximately 300 study subjects are to be randomized to experimental (VR plus algorithms, i.e., intervention) and active comparator (VR only, i.e., control) study arms.
Study subjects will perform a postural tremor test (PTT) to elicit postural parkinsonian tremors.
Our primary outcome is whether the intervention modifies tremor severity.
Study Overview
Detailed Description
The following trial evaluates the effect of Tremor Stabilization Algorithms on involuntary hand tremors suffered by Parkinson's patients.
These algorithms will be implemented in Virtual Reality (VR).
Approximately 300 study subjects are to be randomized to experimental (VR plus algorithms, i.e., intervention) and active comparator (VR only, i.e., control) study arms.
Study subjects will perform a postural tremor test (PTT) to elicit postural parkinsonian tremors.
Our primary outcome is whether the intervention modifies tremor severity.
Secondary outcomes include determining whether tremor severity is reduced long-term.
These measurements will occur 5 minutes to 30 days post-intervention and will not involve VR.
Other secondary outcomes include determining age-of-onset impact on tremor severity, and online self-report surveys for functionality in life in general and in the context of Parkinson's disease.
Subjects will perform tremor-recordings on-site.
Self-reports will be remote.
Study Type
Interventional
Enrollment (Anticipated)
300
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
New York
-
New York, New York, United States, 11233
- NeuroStorm
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
35 years and older (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
- Candidates eligible for our study will be 35 - 85 years, diagnosed with Parkinson's disease, with no falls within 6 months prior to the study, are able to walk for 5 minutes unassisted, have adequate hearing and vision capabilities, can comply with study requirements, have the ability to fill online questionnaires, and provide written informed consent to participate in the study.
Exclusion Criteria:
- Candidates that are ineligible for our study have visual-perceptual deficits that limit capacity to be in VR, have clinical diagnosis of dementia or other severe cognitive impairment as determined by a Mini-Mental State Examination score (MMSE) of less than 24, or have a history of stroke, traumatic brain injury or other neurological disorders
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Triple
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: TSA-ON
The trial will be composed of two arms: an experimental group with VR with activated Tremor Stabilization Algorithms (TSA-ON).
And an active comparator group that is exposed to VR without Tremor Stabilization Algorithms (TSA-OFF control).
In both arms, study subjects will be immersed in a stock VR testing environment and will perform a tremor eliciting PTT test.
|
Our study will be composed of an experimental and an active comparator (i.e., control) arm.
Both arms will perform a postural tremor test (PTT) to elicit parkinsonian tremors.
The PTT is where subjects stabilize their backs against a wall and position their hands in the air against gravity for two minutes.
The experimental arm will receive VR plus activated Tremor Stabilization Algorithms (TSA-ON) while the active comparator arm will receive VR only (TSA-OFF).
Thus, subjects in the experimental arm will not see their digital arms tremor while those in the active comparator arm will.
Our primary outcome is the severity of PTT elicited tremors.
Tremors will be recorded by VR motion-capture controllers.
|
Active Comparator: TSF-OFF control
The trial will be composed of two arms: an experimental group with VR with activated Tremor Stabilization Algorithms (TSA-ON).
And an active comparator group that is exposed to VR without Tremor Stabilization Algorithms (TSA-OFF control).
In both arms, study subjects will be immersed in a stock VR testing environment and will perform a tremor eliciting PTT test.
|
Our study will be composed of an experimental and an active comparator (i.e., control) arm.
Both arms will perform a postural tremor test (PTT) to elicit parkinsonian tremors.
The PTT is where subjects stabilize their backs against a wall and position their hands in the air against gravity for two minutes.
The experimental arm will receive VR plus activated Tremor Stabilization Algorithms (TSA-ON) while the active comparator arm will receive VR only (TSA-OFF).
Thus, subjects in the experimental arm will not see their digital arms tremor while those in the active comparator arm will.
Our primary outcome is the severity of PTT elicited tremors.
Tremors will be recorded by VR motion-capture controllers.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Tremor reduction
Time Frame: 1 minute
|
Our primary outcome is the severity of PTT elicited tremors.
Tremors will be recorded by VR motion-capture controllers.
Wavelet transformation of this data will be applied to determine tremor severity in the two study arms.
|
1 minute
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Collaborators
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
August 1, 2022
Primary Completion (Anticipated)
December 1, 2024
Study Completion (Anticipated)
December 1, 2025
Study Registration Dates
First Submitted
December 18, 2022
First Submitted That Met QC Criteria
December 18, 2022
First Posted (Actual)
December 28, 2022
Study Record Updates
Last Update Posted (Actual)
December 28, 2022
Last Update Submitted That Met QC Criteria
December 18, 2022
Last Verified
December 1, 2022
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 0224506734
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Undecided
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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