- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT06022094
Effect of a Two-month Carbohydrate-restricted Diet on Energy Metabolism in a Seniors' Residence (SAGE)
Effect of a Two-month Carbohydrate-restricted Diet on Energy Metabolism in a Seniors' Residence: The SAGE Study
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Finding an effective therapeutic strategy for Alzheimer's disease (AD) is a societal priority, but it also remains a major challenge. With one exception in 2021, no new pharmaceutical treatment for AD has been approved for over 20 years. However, several clinical trials demonstrate the potential of ketogenic interventions to restore brain energy and improve cognition in people with mild cognitive impairment and AD. Recently, the largest and longest clinical trial of its kind shows that compensating for energy deficit in the brain during aging improves brain metabolic and cognitive functioning in people with early AD and could potentially delay AD.
One of the main types of ketogenic intervention is the highly reduced carbohydrate (5-10% of daily energy value compared to a normal value of 50-65%) and very high fat ketogenic diet. Despite the now well-established safety of the ketogenic diet and its therapeutic value in the treatment of epilepsy and type 2 diabetes, the latter remains difficult to implement in because of the compliance challenge. A reduced glycemic load diet where intake of refined carbohydrates and added sugar is restricted is found to be much less restrictive than a ketogenic diet. Phase 1 of this project showed that decreased carbohydrate (sugar) intake may improve long-term glycemic control and compliance compared to more severe carbohydrate restriction. Having better blood glucose control may also be important in decreasing the risk of AD possibly by improving the metabolic profile and/or by promoting the production and use of ketones. However, its effectiveness in helping cognition in the elderly is still unknown and any changes in dietary habits can be addressed with some resistance.
The objective of this project is therefore to answer the following question: does a reduction in carbohydrates of 30 to 50% for 2 months reduce the risk of AD by improving the metabolic profile in people living in a senior residence?
Study Type
Enrollment (Estimated)
Phase
- Not Applicable
Contacts and Locations
Study Contact
- Name: Camille Vandenberghe, MSc
- Phone Number: 45235 819-780-2220
- Email: camille.vandenberghe@usherbrooke.ca
Study Locations
-
-
Quebec
-
Sherbrooke, Quebec, Canada, J1H 4C4
- Research Center on Aging
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
- Adult
- Older Adult
Accepts Healthy Volunteers
Description
Inclusion Criteria:
- Senior men or women residing in VÜ resident home;
- Understand, read and write French;
- Possess sufficient visual and auditory acuity to pass the cognitive tests;
- Available during the intervention period
Exclusion Criteria:
- Body mass index < 20;
- T1 diabetic;
- Insulin-dependent T2 diabetic;
- Mini Mental State Exam (MMSE) < 20;
- Weight loss >10% in the last 6 months, involuntary or voluntary;
- Known and uncontrolled hypoglycaemia;
- Moderate to severe digestive illnesses that may be aggravated by dietary changes;
- Severe dysphagia;
- Supplementation with medium chain triglycerides oil, ketone salts, ketone ester, adherence to the ketogenic diet, reduced carbohydrate diet, intermittent fasting, or other diet or supplements that may significantly increase ketones in the past month;
- Participation in other intervention research projects on nutrition or aimed at metabolic change simultaneously.
- Medical condition that could prevent the participant from completing the study according to the doctor's opinion
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Prevention
- Allocation: N/A
- Interventional Model: Single Group Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Delta of before/after the intervention
Data will be collected before and after the reduced carb intervention
|
Participants will eat a reduced carb menu for 2 months
Other Names:
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Change in blood glucose levels
Time Frame: 2 months
|
Blood glucose will be monitored continuously with a real-time continuous glucose monitor (CGM) for two 10-days periods; before/after intervention in people in a senior residence.
|
2 months
|
Change in blood ketones levels
Time Frame: 2 months
|
Blood ketones will be measured before/after the intervention in people in a senior residence via blood sampling.
|
2 months
|
Change in blood insulin levels
Time Frame: 2 months
|
Blood insulin will be measured before/after the intervention in people in a senior residence via blood sampling.
|
2 months
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Change in blood triglycerides levels,
Time Frame: 2 months
|
Blood triglycerides levels will be measured before/after the intervention in people in a senior residence via blood sampling.
|
2 months
|
Change in blood cholesterol levels
Time Frame: 2 months
|
Blood cholesterol levels will be measured before/after the intervention in people in a senior residence via blood sampling.
|
2 months
|
Change in blood glycated hemoglobin levels
Time Frame: 2 months
|
Blood glycated hemoglobin levels will be measured before/after the intervention in people in a senior residence via blood sampling.
|
2 months
|
Collaborators and Investigators
Sponsor
Study record dates
Study Major Dates
Study Start (Estimated)
Primary Completion (Estimated)
Study Completion (Estimated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Other Study ID Numbers
- 2024-5195
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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