The Effect of Oral Intake of Animal and Plant Proteins on the Metabolism in Healthy Women (PAN-Promet)

June 22, 2026 updated by: Örebro University, Sweden

The Effect of Oral Ingestion of Animal and Plant-based Proteins on the Somatotropic Axis

The goal of this interventional study is to learn about the effects of different proteins (from animals or plants) on the metabolism in healthy, normal weight women between 18-45 year who are not on hormonal birth-control.

The main questions the study aims to answer are:

  1. How do different proteins affect biological markers of the metabolism and which protein has the strongest effect?
  2. How are the different proteins digested and taken up from our body?

Participants will drink four different shakes on four different study days in a random order. Three of them contain each a different protein and one does not contain protein. Right before drinking the shake and on 11 timepoints after drinking the shake blood samples will be drawn.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

28

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Sweden
      • Örebro, Sweden, 70182
        • Örebro University

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult

Accepts Healthy Volunteers

Yes

Description

Inclusion Criteria:

  • Females
  • Age: 18-45 years
  • Body mass index: 18.5 < 25 kg/m2
  • Signed informed consent

Exclusion Criteria:

  • Use of hormonal contraceptives
  • Pregnancy or breastfeeding
  • Diabetes mellitus or any other metabolic disease that might affect the results of this study
  • Gastric surgery that affects digestion and uptake of protein
  • Any clinically significant present or past disease/condition and medication which in the investigator's opinion could interfere with the results of the trial

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Basic Science
  • Allocation: Randomized
  • Interventional Model: Crossover Assignment
  • Masking: Triple

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Isolated Pea Protein/Isolated Whey Protein/Isolated Faba Bean Protein/Placebo
  • Study day 1: 0.6g isolated pea protein/kg/body weight + 400 ml water
  • Study day 2: 0.6g isolated whey protein/kg/body weight + 400 ml water
  • Study day 3: 0.6g isolated faba bean protein/kg/body weight + 400 ml water
  • Study day 4: 400 ml water

The fat and energy content of the drinks will be adapted using a plant based oil
Dietary supplement: Isolated Pea Protein
Participants will consume the protein supplement dissolved in water in an opaque mug wearing a nose clip.
Dietary supplement: Isolated Whey Protein
Participants will consume the protein supplement dissolved in water in an opaque mug wearing a nose clip.
Dietary supplement: Isolated Faba Bean Protein
Participants will consume the protein supplement dissolved in water in an opaque mug wearing a nose clip.
Dietary supplement: Placebo
Participants will consume the placebo in an opaque mug wearing a nose clip.
Experimental: Isolated Whey Protein/Placebo/Isolated Pea Protein/Isolated Faba Bean Protein
  • Study day 1: 0.6g isolated whey protein/kg/body weight + 400 ml water
  • Study day 2: 400 ml water
  • Study day 3: 0.6g isolated pea protein/kg/body weight + 400 ml water
  • Study day 4: 0.6g isolated faba bean protein/kg/body weight + 400 ml water

The fat and energy content of the drinks will be adapted using a plant based oil
Dietary supplement: Isolated Pea Protein
Participants will consume the protein supplement dissolved in water in an opaque mug wearing a nose clip.
Dietary supplement: Isolated Whey Protein
Participants will consume the protein supplement dissolved in water in an opaque mug wearing a nose clip.
Dietary supplement: Isolated Faba Bean Protein
Participants will consume the protein supplement dissolved in water in an opaque mug wearing a nose clip.
Dietary supplement: Placebo
Participants will consume the placebo in an opaque mug wearing a nose clip.
Experimental: Isolated Faba Bean Protein/Isolated Pea Protein/Placebo/Isolated Whey Protein
  • Study day 1: 0.6g isolated faba bean protein/kg/body weight + 400 ml water
  • Study day 2: 0.6g isolated pea protein/kg/body weight + 400 ml water
  • Study day 3: 400 ml water
  • Study day 4: 0.6g isolated whey protein/kg/body weight + 400 ml water

The fat and energy content of the drinks will be adapted using a plant based oil
Dietary supplement: Isolated Pea Protein
Participants will consume the protein supplement dissolved in water in an opaque mug wearing a nose clip.
Dietary supplement: Isolated Whey Protein
Participants will consume the protein supplement dissolved in water in an opaque mug wearing a nose clip.
Dietary supplement: Isolated Faba Bean Protein
Participants will consume the protein supplement dissolved in water in an opaque mug wearing a nose clip.
Dietary supplement: Placebo
Participants will consume the placebo in an opaque mug wearing a nose clip.
Experimental: Placebo/Isolated Faba Bean Protein/Isolated Whey Protein/Isolated Pea Protein
  • Study day 1: 400 ml water
  • Study day 2: 0.6g isolated faba bean protein/kg/body weight + 400 ml water
  • Study day 3: 0.6g isolated whey protein/kg/body weight + 400 ml water
  • Study day 4: 0.6g isolated pea protein/kg/body weight + 400 ml water

The fat and energy content of the drinks will be adapted using a plant based oil
Dietary supplement: Isolated Pea Protein
Participants will consume the protein supplement dissolved in water in an opaque mug wearing a nose clip.
Dietary supplement: Isolated Whey Protein
Participants will consume the protein supplement dissolved in water in an opaque mug wearing a nose clip.
Dietary supplement: Isolated Faba Bean Protein
Participants will consume the protein supplement dissolved in water in an opaque mug wearing a nose clip.
Dietary supplement: Placebo
Participants will consume the placebo in an opaque mug wearing a nose clip.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Release of Growth Hormone
Time Frame: 0-3 hours after consumption of test drink (on all 4 study days)
The primary outcome is defined as the postprandial release of growth hormone during three hours after oral ingestion of plant-protein test drinks vs. an animal-protein test drink measured as incremental area under the curve. Growth hormone will be measured in blood samples.
0-3 hours after consumption of test drink (on all 4 study days)

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Release of Hormones Related to the Somatotrophic Axis
Time Frame: 0-3 hours after consumption of test drink (on all 4 study days)
We will measure different hormones related to the somatotrophin axis in collected blood samples and investigate if there are differences between different protein-sources.
0-3 hours after consumption of test drink (on all 4 study days)
Kinetics of Amino Acid Uptake
Time Frame: 0-3 hours after consumption of test drink (on all 4 study days)
We will measure amino acids in collected blood samples to investigate dynamics and kinetics of protein digestion/uptake of different protein sources.
0-3 hours after consumption of test drink (on all 4 study days)

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Örebro University, Sweden

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

October 13, 2023

Primary Completion (Actual)

October 24, 2024

Study Completion (Actual)

October 24, 2024

Study Registration Dates

First Submitted

September 13, 2023

First Submitted That Met QC Criteria

September 13, 2023

First Posted (Actual)

September 21, 2023

Study Record Updates

Last Update Posted (Actual)

June 23, 2026

Last Update Submitted That Met QC Criteria

June 22, 2026

Last Verified

June 1, 2026

More Information

Terms related to this study

Keywords

Other Study ID Numbers

  • Dnr 2023-03852-01

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

UNDECIDED

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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