Nailfold Capillaroscopic Assessment in Pediatric Uveitis Patients

Pediatric uveitis accounts for 5-10% of uveitis cases. it may be infectious or noninfectious in etiology. The etiology of noninfectious uveitis may be autoimmune. The most common causes of pediatric uveitis are idiopathic and juvenile idiopathic arthritis-associated uveitis. Uveitis morbidities in pediatric patients include cataract, glaucoma, and amblyopia. Pediatric uveitis may be accopanied by involvement of the ocular vasculature, such as retinal vasculitis. We hypothesize that there are differences in systemic microcirculation between pediatric uveitis patients and healthy pediatric controls.

Study Overview

• Status: Recruiting
• Conditions: Uveitis

Detailed Description

The systemic microcirculation will be investigated through nailfold capillaroscopic (NFC) assessment with noninfectious uveitis and healthy pediatric controls.

The NFC parameters are:

capillary density (number of capillaries per mm), dilated capillaries (apex of >20µm), avascular areas, the presence of microhemorrhages, and capillary morphology (normal, multiple crossings, tortuous, bushy, ramified, non-convex, or bizarre capillaries).

• Study Type: Observational
• Enrollment (Estimated): 50

Contacts and Locations

• Study Contact: Name: Maha Abdelrahman, PHD; Phone Number: 01011212050; Email: mahasayed@aun.edu.eg
• Study Contact Backup: Name: Maha Abdelrahman, MD, PHD; Phone Number: 01011212050; Email: mahasayed@aun.edu.eg

Study Locations

• Egypt
  • Assiut, Egypt, 71515
    • Recruiting
    • Maha Abdelrahman
    • Contact: Maha Abdelrahman, MD, PHD; Phone Number: 01011212050; Email: mahasayed@aun.edu.eg

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Child; Adult
• Accepts Healthy Volunteers: Yes

• Sampling Method: Probability Sample

Study Population

pediatric uveitis patients and healthy pediatric control

Description

Inclusion Criteria:

• patients with uveitis < 18 years old

Exclusion Criteria:

• infectious uveitis
• age > 18 years old

Study Plan

How is the study designed?

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort
pediatric uveitis; pediatric uveitis patients < 18 years old
healthy subjects; healthy subjects< 18 years old

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
capillary density by nailfold capillaroscopy	(number of capillaries per mm)	6 months
detection of number of dilated capillaries by nailfold capillaroscopy	number of dilated capillaries (apex of >20µm)	6 months
detection of other abnormalities as avascular areas, microhemorrhages, and abnormal capillary morphology	detection of multiple crossings, tortuous, bushy, ramified, non-convex, or bizarre capillaries	6 months

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
correlation of nailfold findings with uveitis activity	correlation of capillary abnormalities detected with active uveitis.	6 months

Collaborators and Investigators

• Sponsor: Assiut University
• Investigators: Principal Investigator: Maha Abdelrahman, MD, PHD, Assiut University

Study record dates

Study Major Dates

• Study Start (Actual): January 15, 2024
• Primary Completion (Estimated): May 15, 2024
• Study Completion (Estimated): July 15, 2024

Study Registration Dates

• First Submitted: October 1, 2023
• First Submitted That Met QC Criteria: October 1, 2023
• First Posted (Actual): October 6, 2023

Study Record Updates

• Last Update Posted (Estimated): February 2, 2024
• Last Update Submitted That Met QC Criteria: February 1, 2024
• Last Verified: February 1, 2024

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Eye Diseases; Uveal Diseases; Uveitis
• Other Study ID Numbers: Nailfold capillaroscopy

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No