An Open-label Study of SG1827 in Subjects With Advanced Solid Tumors (CSG-1827-101)

A Phase I Clinical Study to Evaluate the Safety, Tolerability and Preliminary Efficacy of SG1827 in Subjects With Advanced Solid Tumors

This is a Phase I, open-label, dose escalation and dose expansion study to Evaluate the Safety, Tolerability and Preliminary Efficacy of SG1827 in subjects with Advanced Solid Tumors, refractory or resistant to standard therapy, or without available standard or curative therapy.

Study Overview

• Status: Recruiting
• Conditions: Advanced Solid Tumors
• Intervention / Treatment: Drug: SG1827

Detailed Description

After a screening period of up to 28 days for each study phase, qualified patients will be enrolled to receive their assigned dose of SG1827, administered every three weeks (Q3W), until disease progression, intolerable toxicity or others, whichever occurs first.

The study consists of a dose escalation phase (Phase 1a) to determine the maximum tolerated dose (MTD), or recommended Phase 2 dose (RP2D) for SG1827 as a single agent, and a dose expansion phase (Phase 1b) in subjects with specific tumor types which will characterize treatment of SG1827 as a single agent at the MTD or RP2D.

• Study Type: Interventional
• Enrollment (Estimated): 122
• Phase: Phase 1

Contacts and Locations

• Study Contact: Name: Ning LI, Doctor; Phone Number: 010-87788713; Email: lining@cicams.ac.cn

Study Locations

• China
  • Anhui
    • Hefei, Anhui, China, 230001
      • Recruiting
      • The Affiliated Hospital of USTC
      • Contact: Xinghua Han; Phone Number: 86-13856009241; Email: 814277704@qq.com
  • Beijing
    • Beijing, Beijing, China, 100021
      • Recruiting
      • Cancer Hospital Chinese Academy of Medical Sciences
      • Contact: Ning LI; Phone Number: 010-87788713; Email: lining@cicams.ac.cn
  • Henan
    • Zhenzhou, Henan, China, 450003
      • Recruiting
      • Henan Cancer Hospital
      • Contact: Jufeng Wang; Phone Number: 86-1378358396; Email: 13783583966@163.com
  • Hunan
    • Changsha, Hunan, China, 410013
      • Not yet recruiting
      • The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University
      • Contact: Shanzhi Gu; Phone Number: 86-13574865998; Email: gushanzhi@hnca.org.cn
    • Changsha, Hunan, China, 410013
      • Recruiting
      • The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University
      • Contact: Yongchang Zhang; Phone Number: 86-13873123436; Email: zhangyongchang@hnca.org.cn
  • Liaoning
    • Shenyang, Liaoning, China, 110002
      • Not yet recruiting
      • The First Hospital of China Medical University
      • Contact: Funan LIU; Phone Number: 86-13609877906; Email: lfn540@126.com
  • Zhejiang
    • Hangzhou, Zhejiang, China, 310003
      • Recruiting
      • The First Affiliated Hospital, Zhejiang University School of Medicine
      • Contact: Weijia Fang; Phone Number: 86-13758211655; Email: weijiafang@zju.edu.cn
      • Contact: Qingwei Zhao; Phone Number: 86-13588066886; Email: qwzhao@zju.edu.cn

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: No

Description

Inclusion Criteria:

1. Understand and voluntarily sign the informed consent form (ICF).
2. Age ≥18 years.
3. Eastern Cooperative Oncology Group (ECOG) Performance Status score of 0 or 1.
4. Life expectancy ≥3 months.
5. Histologically or cytologically documented advanced or metastatic solid tumors that is refractory/relapsed to standard therapies, or for which no effective standard therapy is available. In the dose-expansion cohorts (Phase 1b), histologically or cytologically confirmed selected advanced solid tumors.
6. Subject must have at least one measurable lesion according to RECIST Version1.1.
7. Adequate organ function.
8. Toxicity caused by prior anti-tumor therapy recovered to Grade 0 to 1 (CTCAE 5.0).
9. Female patients of childbearing potential and male patients whose female partners are of childbearing potential need to use at least one approved contraceptive (e.g., intrauterine device, pill, or condom) during study treatment and for at least 5 months (150 days) after the last dose; female patients of childbearing potential must have a negative blood human chorionic gonadotropin (HCG) test within 7 days prior to dosing and must not be lactating.
10. Male patients must refrain from donating sperm from the time the ICF is signed until at least 5 months after the last dose.

Exclusion Criteria:

1. Subjects with symptomatic central nervous system metastatic lesions; presence of metastases to the brainstem or meninges, spinal cord metastases or compression. Except the subjects who have been treated, be asymptomatic.
2. Active autoimmune disease requiring systemic therapy within the past 2 years (e.g., use of immunomodulatory drugs, corticosteroids, or immunosuppressive medications); related replacement therapy is allowed (e.g., thyroid hormone, insulin, or physiologic corticosteroid replacement for renal or pituitary insufficiency).

3. Have received any of the following treatments or procedures:

   1. Prior treatment with any antitumor therapy targeting CTLA-4.
   2. Subjects received open surgery within 28 days prior to the first dose (except for surgeries for the purpose of biopsy).
   3. Subjects received systemic anticancer therapy (including chemotherapy, targeted therapy, hormonal therapy, immunotherapy and other experimental drugs) within 28 days or 5 drug half-lives (which occurs first) prior to the first dose, and all AEs have not returned to grade ≤1 (CTCAE 5.0).
   4. Subjects received curative radiotherapy within 28 days prior to the first dose; palliative radiotherapy is allowed if which occurs within 14 days prior to the first dose, and all AEs have not returned to grade ≤1 (CTCAE 5.0).
   5. Any live vaccine within 28 days prior to the first dose.
   6. Prior allogeneic organ grafting or allogeneic stem cell transplantation.
4. Subjects received systemic corticosteroids (equivalent dose > 10 mg/day of prednisone) or other immunosuppressive drugs within 14 days prior to the first dose or will receive during the study. Except topical or prophylactic treatment for non-autoimmune diseases.
5. Presence of active infection requiring antibiotic therapy within 30 days prior to the first dose, except for prophylaxis use.

6. Presence of cardiovascular system disease within 6 months prior to screening that meets any of the following:

   1. Cardiac function: congestive heart failure of New York Heart Association (NYHA) class III or IV; left ventricular ejection fraction <50%.
   2. Clinically significant cardiac disease or surgery , including myocardial infarction, unstable angina pectoris, coronary/peripheral artery bypass, etc.
   3. QTcF >450 ms (corrected QT interval with Fridericia formula); history of clinically significant ventricular arrhythmias (e.g., sustained ventricular tachycardia, ventricular fibrillation, tip-twist ventricular tachycardia); history or family history of congenital long QT syndrome; arrhythmias requiring antiarrhythmic drug therapy (patients with atrial fibrillation with controllable heart rate 1 month prior to the first dose of the investigational drug may be enrolled).
   4. History of arterial thrombosis, deep venous thrombosis and pulmonary embolism.
7. Hyperglycaemia or Hypertension that has not been effectively controlled after standard treatment.
8. Patients with active hepatitis B or C, or HIV antibody positive.
9. Known history of Grade 3 to 4 hypersensitivity reactions to any biological product, history of life threatening hypersensitivity reactions, or known hypersensitivity to components of SG1906 drug product.
10. History of interstitial lung disease or non-infectious pneumonitis except for those induced by radiation therapies.
11. Presence of body fluid (hydrothorax, ascites, pericardial effusion, etc.) requiring local treatment or repeated drainage.
12. Immune-related adverse effects leading to permanent discontinuation during previous antineoplastic immunotherapy.
13. Subjects with unhealed wounds.
14. Subjects with high risk of bleeding.
15. Subjects with other malignant solid tumors (except for cured defined tumors) within 5 years prior to the first dose.
16. Any other condition that, in the opinion of the Investigator, may lead to inappropriate participation in this study.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: N/A
• Interventional Model: Single Group Assignment
• Masking: None (Open Label)

Number of Arms

1

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: SG1827; SG1827 monotherapy intravenous (IV) infusion - administered every three weeks (Q3W)	Drug: SG1827; PhaseⅠa will use an accelerated titration and Bayesian optimal interval (AT-BOIN) design with 7 dose cohorts: 0.02mg/kg, 0.2mg/kg, 1mg/kg, 3mg/kg, 6mg/kg, 10mg/kg, and 15mg/kg by IV infusion. Accelerated titration (1 patient) will be only applied to the first cohort.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Incidence of Treatment-Emergent Adverse Events	Number and percentage of AEs which is calculated by worst CTCAE grade by CTCAE 5.0	Through study completion, an average of one year
MTD/MAD/ RP2D	MTD/MAD/RP2D will be determined based on the DLTs and safety data.	Through study completion, an average of one year

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Pharmacokinetics (PK):limination half-life (T1/2)	limination half-life (T1/2) of the drug after administration.	Through study completion, an average of one year
Immunogenicity endpoints:	levels of anti-drug antibodies (ADAs) and neutralizing antibodies (tested in ADA-positive samples only).	Through study completion, an average of one year
Pharmacokinetics (PK): Cmax	Cmax to maximum drug concentrationadministration	Through study completion, an average of one year
PD endpoints: cytokine levels	including but not limited to tumor necrosis factor (TNF)-α, interferon gamma (IFN-γ), interleukin (IL)-2, IL-4, IL-6, IL-8, IL-10, IL-1β.	Through study completion, an average of one year
Efficacy endpoints:	objective response rate (ORR),	Through study completion, an average of one year

Collaborators and Investigators

• Sponsor: Hangzhou Sumgen Biotech Co., Ltd.

Study record dates

Study Major Dates

• Study Start (Actual): September 27, 2023
• Primary Completion (Estimated): December 28, 2024
• Study Completion (Estimated): March 28, 2025

Study Registration Dates

• First Submitted: September 24, 2023
• First Submitted That Met QC Criteria: October 6, 2023
• First Posted (Actual): October 10, 2023

Study Record Updates

• Last Update Posted (Actual): March 20, 2024
• Last Update Submitted That Met QC Criteria: March 19, 2024
• Last Verified: March 1, 2024

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Neoplasms
• Other Study ID Numbers: CSG-1827-101

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No