Study of the Location of Motor Cortical Stimulation Electrodes in Chronic Neuropathic Refractory Patients

June 25, 2026 updated by: Centre Hospitalier Universitaire de Nice

Cortical stimulation has been used since 1991 to treat neuropathic pain. However, the underlying mechanisms are still incompletely understood and under-studied. In this protocol, the investigators aim to study the myeloarchitectonic and functional characteristics of areas activated by cortical epidural electrodes and to determine their relation to therapy response in chronic neuropathic refractory pain patients.

Study Overview

Status

Recruiting

Conditions

Neuropathic Pain

Study Type

Observational

Enrollment (Estimated)

100

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Name: Petru ISAN
Phone Number: +33 0642619135
Email: isan.p@chu-nice.fr

Study Contact Backup

Name: Cynthia CAILLON
Phone Number: +33 0492034589
Email: caillon.c@chu-nice.fr

Study Locations

France
- Alpes Maritimes
  - Nice, Alpes Maritimes, France
    - Recruiting
    - CHU NICE
    - Contact:
      
      petru isan
      
      Phone Number: + 33 064219135
      
      Email: isan.p@chu-nice.fr
    - Contact:
      
      cynthia caillon
      
      Phone Number: +33 0492034589
      
      Email: caillon.@chu-nice.fr

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

Adult
Older Adult

Accepts Healthy Volunteers

N/A

Sampling Method

Non-Probability Sample

Study Population

adults who were implanted with a motor cortical stimulation system for treatment of chronic neuropathic refractory pain between 2003-2023

Description

Inclusion Criteria

adults
patient implanted with a motor cortical stimulation system for chronic neuropathic refractory pain,
patient with available postoperative scanner

Exclusion Criteria: None

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Pourcentage of pain relief Time Frame: 1 year	percentage of pain relief for different stimulated areas	1 year

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
location of leads on the postoperative imaging Time Frame: 1 month	location of leads on the postoperative imaging	1 month

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Centre Hospitalier Universitaire de Nice

Investigators

Principal Investigator: Petru ISAN, Centre Hospitalier Universitaire De Nice

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

November 13, 2023

Primary Completion (Actual)

March 16, 2025

Study Completion (Estimated)

June 25, 2027

Study Registration Dates

First Submitted

January 11, 2024

First Submitted That Met QC Criteria