Effects of Muscle Strengthening and Fatigue on Activities in Cortex and Muscle (YM110099E)

Effects of Cross Education Training on Corticocortical and Corticomuscular Functional Connectivity

We will explored the effect of cross education training on different cortex functional connectivity, cortex and muscle functional connectivity, and maximal voluntary contraction.

Healthy participants receive cross education training of the elbow flexor (12 rep./set, 3sets, 60%MVC, 180°/s, eccentric).Maximal voluntary contraction, electroencephalogram and electromyogram will record during cross education tasks to determine the effects of cross education training on cortical network and muscle functional connectivity

Study Overview

• Status: Completed
• Conditions: Healthy Adults
• Intervention / Treatment: Other: Cross education

Detailed Description

Cross education (CE) training was observed in 1894, when unilateral strength training of single limb was found to increase in strength of untrained muscle group. CE has potential clinical relevance in rehabilitation for patient who have acute injuries of the limb, post-surgical limb immobilization and certain neurological disorders with unilateral muscle weakness. Although CE has several potential clinical application, the precise physiological mechanisms underlying CE remains unknown. Previous studies reported that CE may involve bilateral cortical activity in both contralateral primary motor cortex (cM1), and ipsilateral primary motor cortex (iM1).In addition, neuroimaging studies have demonstrated that bilateral supplementary motor area, but CE immediate change of functional connectivity in cortical network remains unknown.

The purposes of this study are to investigate the immediate effect of CE training of biceps brachii (1) Immediate change of functional connectivity in cortical network; (2) Immediate change of functional connectivity in cortex and target muscle; (3) Explore immediate change of corticomuscular functional connectivity on maximal voluntary contraction. We hypothesize that (1) Bilateral cortical motor network that exhibit changes in functional connectivity during cross education; (2) Cross education would immediately enhance functional connectivity between cortex and target muscle; (3) Cross education would immediately change corticomuscular functional connectivity on maximal isometric voluntary contraction.

• Study Type: Interventional
• Enrollment (Actual): 40
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Taiwan
  • Taipei, Taiwan, 112
    • National Yang-Ming University

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult
• Accepts Healthy Volunteers: Yes

Description

Inclusion Criteria:

1. Healthy adults who are 20-40 years old

Exclusion Criteria:

1. Upper extremity (UE) pain or discomfort
2. Medical condition that substantially influenced their UE strength
3. Experience of UE surgery
4. Paresthesia in UE
5. Open wound on UE

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Basic Science
• Allocation: N/A
• Interventional Model: Single Group Assignment
• Masking: None (Open Label)

Number of Arms

1

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Cross education training group; Cross education on elbow flexor	Other: Cross education; Cross education training of the biceps brachii (12 rep./set, 3sets, 60%MVIC,180°/s, eccentric contraction)

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Corticocortical coherence	Level of electroencephalography and electromyography synchronization in frequency domain when participants maintain 20% maximal voluntary contraction	Measured immediately after cross education training
Corticomuscular coherence	Level of electroencephalography and electromyography synchronization in frequency domain when participants maintain 20% maximal voluntary contraction	Measured immediately after cross education training
Maximal voluntary contraction	The ability to generate maximal voluntary elbow flexor force	Measured immediately after cross education training

Collaborators and Investigators

• Sponsor: National Yang Ming University
• Investigators: Principal Investigator: Li-Wei Chou, Ph.D., Department of Physical Therapy and Assistive and Technology ,National Yang-Ming University

Study record dates

Study Major Dates

• Study Start (Actual): May 1, 2021
• Primary Completion (Actual): April 30, 2022
• Study Completion (Actual): August 1, 2022

Study Registration Dates

• First Submitted: March 20, 2024
• First Submitted That Met QC Criteria: March 20, 2024
• First Posted (Actual): March 27, 2024

Study Record Updates

• Last Update Posted (Actual): March 27, 2024
• Last Update Submitted That Met QC Criteria: March 20, 2024
• Last Verified: December 1, 2022

More Information

Terms related to this study

• Keywords: cross education, functional connectivity
• Other Study ID Numbers: YM110099E

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No