China Healthy Aging Cohort Study (China-Ageing)

This is a community-based prospective cohort study in China. The study has been initialized in 2024 and included older residents. The goal of this observational study is to explore the risk factors related to disability and dementia in the elderly Chinese community population, and develop a risk prediction model for disability and dementia.

Study Overview

• Status: Recruiting
• Conditions: Death; Dementia; Disability; Age Problem
• Intervention / Treatment: Other: No intervention

Detailed Description

This is a community-based prospective cohort study in China. Individuals who were aged 60 years or older, had lived in the communities for more than 1 year, and had signed the informed consent form were enrolled in the present study. The study has been initiated in 2024 and aimed to explore the risk factors related to disability and dementia in the elderly Chinese population, and develop a risk prediction model for disability and dementia. This work consists of three steps as follows. First, by integrating the data of the elderly cohort of 4 communities in Beijing, Shenzhen, Haikou and Hangzhou, we plan to establish a Chinese elderly database. Second, to explore the risk factors of disability and dementia in elderly Chinese. Third, to construct risk prediction models of disability and dementia in Chinese elderly.

• Study Type: Observational
• Enrollment (Estimated): 6780

Contacts and Locations

• Study Contact: Name: Yi Tang, MD., PhD; Phone Number: 00861083199456; Email: tangyi@xwhosp.org

Study Locations

• China
  • Beijing, China, 100053
    • Recruiting
    • Xuanwu Hospital, Capital Medical University
    • Contact: Yi Tang, M.D., Ph.D.; Phone Number: 00861083199456; Email: tangyi@xwhosp.org

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: Yes

• Sampling Method: Non-Probability Sample

Study Population

Community residents aged 60 years or older in China

Description

Inclusion Criteria:

• Aged 60 years or older
• Lived in the community for more than 1 year
• Signed the informed consent form

Exclusion Criteria:

• Cannot complete the survey

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Total; All subjects	Other: No intervention; No intervention

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
The prevalence and incidence of functional disability using a population-based survey	Functional disability was measured by Activities of Daily Living, cognitive function (Mini-Mental State Examination) and movement disorder（Short Physical Performance Battery) collected by questionnaires.The minimum value of the Activities of Daily Living is 0, and the maximum value is 100, the higher the score, the better the outcome.The minimum value of the Mini-Mental State Examination is 0, and the maximum value is 30, the higher the score, the better the outcome.The minimum value of the Short Physical Performance Battery is 0, and the maximum value is 12, the higher the score, the better the outcome.	An average of 1 to 2 years
The prevalence and incidence of mild cognitive impairment using a population-based survey	Mild cognitive impairment was measured using Mini-Mental State Examination collected by questionnaire.The minimum value of the Mini-Mental State Examination is 0, and the maximum value is 30, the higher the score, the better the outcome.	An average of 1 to 2 years
The prevalence and incidence of dementia using a population-based survey	Dementia was determined by diagnosis of hospitalization or diagnosis of death or Clinical Dementia Rating scale. The minimum value of the Clinical Dementia Rating is 0, and the maximum value is 3, the higher the score, the worse the outcome.	An average of 1 to 2 years
The conversion rate of normal to mild cognitive impairment	Percentage of enrolled population that convert from normal to mild cognitive impairment	An average of 1 to 2 years
The conversion rate of mild cognitive impairment to dementia	Percentage of enrolled population that convert from mild cognitive impairment to dementia	An average of 1 to 2 years
The prevalence and incidence of movement disorder using a population-based survey	Movement disorder was measured using Short Physical Performance Battery collected by questionnaire.The minimum value of the Short Physical Performance Battery is 0, and the maximum value is 12, the higher the score, the better the outcome.	An average of 1 to 2 years

Collaborators and Investigators

• Sponsor: Xuanwu Hospital, Beijing
• Investigators: Principal Investigator: Yi Tang, MD., PhD, Xuanwu Hospital, Beijing

Study record dates

Study Major Dates

• Study Start (Actual): June 13, 2024
• Primary Completion (Estimated): June 1, 2063
• Study Completion (Estimated): June 1, 2063

Study Registration Dates

• First Submitted: June 17, 2024
• First Submitted That Met QC Criteria: June 23, 2024
• First Posted (Actual): June 25, 2024

Study Record Updates

• Last Update Posted (Actual): June 25, 2024
• Last Update Submitted That Met QC Criteria: June 23, 2024
• Last Verified: June 1, 2024

More Information

Terms related to this study

• Keywords: Disability, Dementia, Ageing, Cohort
• Additional Relevant MeSH Terms: Mental Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Neurocognitive Disorders; Dementia
• Other Study ID Numbers: 2024214001

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No