Assessment of Human Exposure to Chemical Hazards

Assessment of Human Exposure to Chemical Hazards and Their Association With Food Consumption in the Singapore Population

The aim of this study is to evaluate the occurrence of chemical hazards exposure in the Singapore population and assess their association with food consumption.

Study Overview

• Status: Active, not recruiting
• Conditions: Dietary Exposure
• Intervention / Treatment: Other: Food Frequency, Social, Lifestyle, Demographic Questionnaires and Blood Collection

Detailed Description

Human biomonitoring is an exposure assessment approach with the potential value-add supplementation to existing sources of information for regulatory risk assessments and for supporting food safety policies. The collaboration involving academic partners from the sciences and public health disciplines to quantify the in vivo chemical exposure of chemicals will take reference from the findings in the Singapore's total diet study on the prioritised chemical hazards of interest for a more precise assessment of the distribution of risk in the population. Direct measurement of chemicals and/or metabolites in biological specimens obtained from study subjects will be conducted to provide a more comprehensive understanding on the baseline dietary chemical exposure in the local population. Dietary assessment using food frequency questionnaire will be administered to the same group of study subjects to associate human exposure to chemical hazards with food consumption across the different population groups in Singapore.

• Study Type: Observational
• Enrollment (Estimated): 300

Contacts and Locations

Study Locations

• Singapore
  • Singapore, Singapore, 118177
    • National University of Singapore
  • Singapore, Singapore
    • National University of Singapore, Department of Food Science & Technology

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult
• Accepts Healthy Volunteers: Yes

• Sampling Method: Probability Sample

Study Population

Healthy adults in the Singapore population

Description

Inclusion Criteria:

• Must be English-literate and able to give informed consent in English
• 21 to 60 years of age (inclusive) at screening
• Healthy adults
• Race must be Chinese or Indian or Malay
• Reliable and willing to make themselves available for the duration of the study and are willing to follow study procedures

Exclusion Criteria:

• Known or ongoing psychiatric disorders within 3 years
• Being diagnosed with cancer, heart disease, stroke, renal failure, serious mental or physical illnesses at the time of recruitment
• Have donated blood of more than 500 mL within 4 weeks of study enrolment

Study Plan

How is the study designed?

Number of groups / cohorts

3

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Ethnicity: Chinese	Other: Food Frequency, Social, Lifestyle, Demographic Questionnaires and Blood Collection; Questionnaires on food frequency, social, lifestyle, and demographics will be administered to participants and will be correlated with the presence of chemical hazards in the blood. The chemical hazards analyzed will be referenced from Singapore's Total Diet Study, based on the prioritized chemical hazards of interest to investigate the distribution of risk in the population.
Ethnicity: Malay	Other: Food Frequency, Social, Lifestyle, Demographic Questionnaires and Blood Collection; Questionnaires on food frequency, social, lifestyle, and demographics will be administered to participants and will be correlated with the presence of chemical hazards in the blood. The chemical hazards analyzed will be referenced from Singapore's Total Diet Study, based on the prioritized chemical hazards of interest to investigate the distribution of risk in the population.
Ethnicity: Indian	Other: Food Frequency, Social, Lifestyle, Demographic Questionnaires and Blood Collection; Questionnaires on food frequency, social, lifestyle, and demographics will be administered to participants and will be correlated with the presence of chemical hazards in the blood. The chemical hazards analyzed will be referenced from Singapore's Total Diet Study, based on the prioritized chemical hazards of interest to investigate the distribution of risk in the population.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Chemical hazards occurrence	To evaluate the occurrence of chemical hazards exposure in the Singapore population and assess their association with food consumption.	3 years

Collaborators and Investigators

• Sponsor: National University of Singapore
• Collaborators: Singapore Food Agency
• Investigators: Principal Investigator: Mei Hui Liu, National University of Singapore

Study record dates

Study Major Dates

• Study Start (Actual): August 21, 2024
• Primary Completion (Estimated): July 31, 2027
• Study Completion (Estimated): July 31, 2027

Study Registration Dates

• First Submitted: July 24, 2024
• First Submitted That Met QC Criteria: July 24, 2024
• First Posted (Actual): July 29, 2024

Study Record Updates

• Last Update Posted (Estimated): September 9, 2025
• Last Update Submitted That Met QC Criteria: September 2, 2025
• Last Verified: September 1, 2025

More Information

Terms related to this study

• Other Study ID Numbers: NUS-IRB-2024-128

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: No