Investigation of the Effect of I-PRF Application on Pain in Alveolitis

February 18, 2025 updated by: Gorkem Tekin, Eskisehir Osmangazi University
Literature review showed that there are no studies on the use of i-PRF in alveolitis cases. The aim of this study was to investigate the effect of i-PRF on the treatment of alveolitis. The hypothesis of the study was that i-PRF applied to alveolitis patients would reduce pain.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

The present study will include 60 healthy patients over 18 years of age with alveolitis. 60 patients will be randomly divided into two groups: Control and I-PRF. After irrigation of the sockets, no substance will be applied to the control group, and I-PRF will be applied to the study group. Postoperative pain will be measured on the 3rd and 7th days.

Study Type

Interventional

Enrollment (Actual)

60

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Turkey
      • Eskişehir, Turkey, 26480
        • Eskisehir Osmangazi University

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

Yes

Description

Inclusion Criteria:

Healthy individuals without systemic disease Patients with complete data and attending their appointments

Exclusion Criteria:

Patients who smoke Pregnant or breastfeeding female patients with bleeding disorders and diabetics Patients currently or previously using bisphosphonates or receiving radiotherapy to the jaw Patients unable to consent to participate in the study

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Other
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Double

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: I-PRF
I-PRF Application
Device: I-PRF
After local anesthesia is injected, alveolar curettage is performed and the socket is irrigated with saline solution. I-PRF is given to patients in the experimental group.
Active Comparator: Standard treatment
standard treatment
Other: Control
After local anesthesia is injected, alveolar curettage is performed and the socket is irrigated with saline solution.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Change in post-operative pain assessed: visual analog (VAS) scale
Time Frame: postoperative 3rd, and 7th days
VAS measured on a 10cm scale, where 0 represents no pain and 10 represents maximum pain
postoperative 3rd, and 7th days

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Eskisehir Osmangazi University

Investigators

  • Study Chair: Görkem TEKİN, Assist.Prof., Eskişehir Osmangazi University Faculty of Dentistry

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

October 20, 2024

Primary Completion (Actual)

February 18, 2025

Study Completion (Actual)

February 18, 2025

Study Registration Dates

First Submitted

December 30, 2024

First Submitted That Met QC Criteria

January 6, 2025

First Posted (Actual)

March 25, 2025

Study Record Updates

Last Update Posted (Actual)

March 25, 2025

Last Update Submitted That Met QC Criteria

February 18, 2025

Last Verified

February 1, 2025

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • EskisehirOU-TEKIN-001

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

IPD Plan Description

IPD may share with other researchers upon request

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

product manufactured in and exported from the U.S.

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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