Community Burden of MG Infection

Community Burden of Mycoplasma Genitalium Infection and Its Implications for Test-and-treat Strategies

Objective: To assess the burden and the transmission dynamics of Mycoplasma genitalium (MG) infection in men who have sex with men in Hong Kong.

Design and setting: involving a) a cross-sectional study (completion of an online self-administered survey, followed by self-sampling for testing in the laboratory, and performance of HIV self-test); b) a mathematical modelling study to simulate the transmission dynamics of MG infection and resistant MG infection and compare the impacts of test-and-treat strategies.

Participants: Around 920 men who have sex with men would be recruited

Study Overview

• Status: Recruiting
• Conditions: Mycoplasma Genitalium Infection; Sexually Transmitted Infection (STI)

Detailed Description

Cross-sectional study: A total of 920 men who have sex with men aged 18 or above and normally living in Hong Kong would be recruited. Eligible participants would be asked to complete a self-administered online survey, submit self-collected urine specimen and rectal swabs for Chlamydia trachomatis, Neisseria gonorrhoeae, and Mycoplasma genitalium testing in the laboratory, and submit HIV self-test results.

Mathematical modelling study: A compartmental model would be constructed to simulate the transmission dynamics of MG infection and resistant MG infection, and analyse the impact of different test-and-treat strategies.

• Study Type: Observational
• Enrollment (Estimated): 920

Contacts and Locations

Study Locations

• Hong Kong
  • Hong Kong, Hong Kong, 0000
    • Recruiting
    • The Chinese University of Hong Kong
    • Contact: Ngai Sze Wong, PhD; Phone Number: 22528862; Email: candy_wong@cuhk.edu.hk

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: Yes

• Sampling Method: Non-Probability Sample

Study Population

men who have sex with men in Hong Kong

Description

Inclusion Criteria:

• men who have sex with men aged 18 or above, normally living in Hong Kong, and could communicate in written and spoken English or Chinese

Exclusion Criteria:

• cannot provide consent

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
prevalence of MG infection	detection of MG infections in self-collected samples divided by the total number of samples collected	1 year
prevalence of MG resistance mutations	detection of MG resistance mutations macrolide/fluoroquinolone in MG positive samples divided by the total number of MG positive samples	1 year

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
prevalence of CT infection	detection of CT infections in self-collected samples divided by the total number of samples collected	1 year
prevalence of NG infection	detection of NG infections in self-collected samples divided by the total number of samples collected	1 year
co-infection of STIs	number of co-infection of HIV, CT, NG, and/or MG	1 year
history of STI and HIV testing	number of self-reported history of STI and/or HIV testing at survey	ever

Collaborators and Investigators

• Sponsor: Chinese University of Hong Kong

Study record dates

Study Major Dates

• Study Start (Actual): February 18, 2025
• Primary Completion (Estimated): June 30, 2026
• Study Completion (Estimated): December 31, 2027

Study Registration Dates

• First Submitted: January 21, 2025
• First Submitted That Met QC Criteria: January 21, 2025
• First Posted (Actual): March 25, 2025

Study Record Updates

• Last Update Posted (Actual): March 25, 2025
• Last Update Submitted That Met QC Criteria: March 14, 2025
• Last Verified: March 1, 2025

More Information

Terms related to this study

• Keywords: men who have sex with men; Mycoplasma genitalium; Chlamydia trachomatis; Neisseria gonorrhoeae
• Additional Relevant MeSH Terms: Urogenital Diseases; Genital Diseases; Pathologic Processes; Disease Attributes; Respiratory Tract Infections; Respiratory Tract Diseases; Lung Diseases; Pneumonia; Bacterial Infections; Bacterial Infections and Mycoses; Gram-Negative Bacterial Infections; Pleural Diseases; Pleurisy; Mycoplasmatales Infections; Infections; Communicable Diseases; Sexually Transmitted Diseases; Pleuropneumonia; Mycoplasma Infections
• Other Study ID Numbers: MGMSM1

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No