The Development of Diagnosis and Prognosis Predictive Model for Peripheral Nerve Disease

The Development of Diagnosis and Prognosis Predictive Model for Peripheral Nerve Disease Using Big Data From Magnetic Resonance Neurography: A Multicenter Cohort Study（MRN-PND）

This is a retrospective observational cohort study (MRN-PND), aiming to explore the utility of contrast-enhanced MRN (ceMRN) compared to plain MRN in diagnosing peripheral nerve diseases and predicting the prognosis of patients with these conditions. Additionally, artificial intelligence (AI) methods are employed to enhance the diagnostic accuracy of MRN for peripheral nerve diseases and to precisely predict disease outcomes.

Study Overview

• Status: Completed
• Conditions: Peripheral Nerve Disease

• Study Type: Observational
• Enrollment (Actual): 10000

Contacts and Locations

Study Locations

• China
  • Hubei
    • Wuhan, Hubei, China, 430000
      • Union Hospital，Tongji Medical College，Huazhong University of Science and Technology

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: Yes

• Sampling Method: Non-Probability Sample

Study Population

Healthy People and Patients with Peripheral Nerve Disease

Description

Inclusion Criteria:

1. Patients who underwent MRN scanning at Wuhan Union Hospital between January 2015 and January 2025;
2. Age > 18 years;
3. Definitive clinical diagnosis (either healthy individuals or patients with a specific condition).

Exclusion criteria：

1. Poor quality of imaging;
2. Incomplete clinical data or loss to follow-up;
3. Unclear clinical diagnosis.

Study Plan

How is the study designed?

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort
Healthy Volunteers
Patients with Peripheral Nerve Disease

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Correlation analysis of MR information and diagnosis outcome	The indicator is the area under the curve of the predict diagnosis outcome.	0.5 year

Collaborators and Investigators

• Sponsor: Wuhan Union Hospital, China
• Collaborators: West China Hospital; University Hospital Heidelberg; Wuhan No.1 Hospital

Study record dates

Study Major Dates

• Study Start (Actual): January 1, 2015
• Primary Completion (Actual): January 1, 2025
• Study Completion (Actual): January 1, 2025

Study Registration Dates

• First Submitted: February 12, 2025
• First Submitted That Met QC Criteria: February 24, 2025
• First Posted (Actual): March 25, 2025

Study Record Updates

• Last Update Posted (Actual): March 25, 2025
• Last Update Submitted That Met QC Criteria: February 24, 2025
• Last Verified: February 1, 2025

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Neuromuscular Diseases; Peripheral Nervous System Diseases; Nervous System Diseases
• Other Study ID Numbers: 2025-0015-01

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No