Prevalence of Complex PTSD in Trauma-Exposed Children-Adolescents and Related Factors

Identifying the Prevalence of Complex Post-Traumatic Stress Disorder in Trauma-Exposed Children and Adolescents and Examining Related Factors

The aim of this study is to assess the psychiatric evaluation of children and adolescents exposed to trauma in the outpatient clinic and to determine the prevalence of PTSD and Complex PTSD (CPTSD) diagnoses. Additionally, it aims to compare the clinical characteristics of children exposed to trauma who do not receive a PTSD diagnosis, those diagnosed with PTSD, and those diagnosed with CPTSD, as well as to examine the trauma history of their parents and the severity of their anxiety and depression. Furthermore, since there is no existing scale to assess CPTSD in children in our country, the study also aims to translate the International Trauma Questionnaire - Child and Adolescent Version into Turkish and evaluate its psychometric properties.

Study Overview

• Status: Recruiting
• Conditions: Complex Post-Traumatic Stress Disorder (CPTSD); Post-traumatic Stress Disorder (PTSD)

Detailed Description

The study will be conducted under the coordination of the Department of Child and Adolescent Psychiatry at Istanbul Faculty of Medicine. The sample will consist of children and adolescents who have been identified by their attending physician as having experienced trauma and have been referred to participate in the study at the Child and Adolescent Psychiatry outpatient clinic of Istanbul Faculty of Medicine.

Sample:

• Children and adolescents aged 7-18,
• Children and adolescents who have experienced trauma and applied to the Child and Adolescent Psychiatry outpatient clinic of Istanbul Faculty of Medicine,
• Children and/or parents with adequate literacy and Turkish language skills,
• Those without psychotic/manic symptoms or a diagnosis of autism spectrum disorder or intellectual disability in the child or parent during the interview,
• Volunteers who agree to participate in the study.

Researchers will explain the study to volunteer children and their families and present the Informed Consent Form to determine their willingness to participate.

Parents of eligible volunteers will complete the following assessments:

• Sociodemographic Data Form
• Hospital Anxiety and Depression Scale
• Advers Childhood Events Scale
• Positive Childhood Experiences Scale
• Strengths and Difficulties Questionnaire (Parent Form)

Volunteer children and adolescents will complete:

• International Trauma Questionnaire - Child and Adolescent Version
• Revised Children's Anxiety and Depression Scale
• Positive Childhood Experiences Scale
• (Adolescent/Child's Self Report) Responses to Stress Questionnaire (Peer Stress)

The clinician will conduct the following assessments:

• ICD-11-based clinical interview
• UCLA PTSD Reaction Index for DSM-5
• Children's Global Assessment Scale (CGAS)

Afterward, volunteers included in the study will complete computer-based Emotion Recognition and Differentiation Tests.

For children exposed to trauma applying to the Istanbul Faculty of Medicine Child and Adolescent Mental Health and Disorders Clinic, psychiatric diagnoses will be shared with their physician upon patient approval. These children will be followed and treated in the clinic according to current guideline-recommended treatment methods.

The planned start date for the study is January 30, 2025, and data analysis will commence afterward. Data will be analyzed using the Statistical Program for Social Sciences (SPSS for Windows, version 21.0). The study is expected to be completed by June 2025.

The coordinating center responsible for the research is the Department of Child and Adolescent Mental Health and Disorders at Istanbul Faculty of Medicine.

• Study Type: Observational
• Enrollment (Estimated): 120

Contacts and Locations

• Study Contact: Name: Beyza N Karal, MD; Phone Number: +9002124142000; Email: beyzakaral@istanbul.edu.tr

Study Locations

• Turkey
  • Fatih
    • Istanbul, Fatih, Turkey, 34116
      • Recruiting
      • Istanbul Faculty of Medicine
      • Contact: Beyza N Karal, MD; Phone Number: +9002124142000; Email: beyzakaral@istanbul.edu.tr

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Child; Adult
• Accepts Healthy Volunteers: No

• Sampling Method: Non-Probability Sample

Study Population

Patients applying to the Child and Adolescent Mental Health and Disorders Outpatient Clinic of Istanbul Faculty of Medicine

Description

Inclusion Criteria:

• Having been exposed to at least one traumatic event,
• Being between the ages of 7 and 18,
• The child and/or their parents (or caregivers) having adequate literacy and Turkish communication skills.

Exclusion Criteria:

• The presence of psychotic/manic symptoms in the child or parent during the interview or any condition that makes the interview and assessment impossible (e.g., mental or developmental condition or a different communication language),
• The child or parent refusing to participate in the study,
• The presence of autism spectrum disorder or intellectual disability at a severity that prevents assessment.

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Prevalence of Complex PTSD in Children and Adolescents Exposed to Trauma	The aim of this study is to conduct a psychiatric evaluation of children and adolescents exposed to trauma in the outpatient clinic and to determine the prevalence of PTSD and Complex PTSD (CPTSD) diagnoses.	Baseline
Examining the Differences Between Groups Who Do Not Have a PTSD Diagnosis, Those Diagnosed with PTSD, and Those Diagnosed with Complex PTSD (CPTSD)	The study aims to compare the clinical characteristics of children exposed to trauma who do not receive a PTSD diagnosis, those diagnosed with PTSD, and those diagnosed with CPTSD, as well as to examine the trauma history of their parents and the severity of their anxiety and depression. Additionally, it will also be examined whether there is a difference in facial emotion recognition skills among these groups.	Baseline
Adaptation of the International Trauma Questionnaire - Child and Adolescent Version into Turkish and Evaluation of Its Psychometric Properties	Since there is no existing scale in our country to assess CPTSD in children, the study also aims to translate the International Trauma Questionnaire - Child and Adolescent Version into Turkish and evaluate its psychometric properties.	Baseline

Collaborators and Investigators

• Sponsor: Istanbul University
• Investigators: Principal Investigator: Abdurrahman Cahid Orengul, Associate Professor, MD, Istanbul Faculty of Medicine, Child and Adolescent Psychiatry Department

Study record dates

Study Major Dates

• Study Start (Actual): January 30, 2025
• Primary Completion (Estimated): June 1, 2025
• Study Completion (Estimated): July 1, 2025

Study Registration Dates

• First Submitted: March 20, 2025
• First Submitted That Met QC Criteria: April 2, 2025
• First Posted (Actual): April 9, 2025

Study Record Updates

• Last Update Posted (Actual): April 9, 2025
• Last Update Submitted That Met QC Criteria: April 2, 2025
• Last Verified: April 1, 2025

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Trauma and Stressor Related Disorders; Mental Disorders; Stress Disorders, Traumatic; Stress Disorders, Post-Traumatic
• Other Study ID Numbers: 2025/82 (Other Identifier: Recep Tayyip Erdoğan University Clinical Research Ethics Committee)

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: No